Am J Transplant, Volume 20, Suppl 3 Archives - Page 26 of 223 - ATC Abstracts

2020 American Transplant Congress
Single Cell Analysis of Living Donor Kidneys Characterizes Resident Parenchymal and Immune Populations in Male and Female Donors
C. McEvoy¹, J. Szusz², S. Clotet-Freixas¹, J. An², S. Crome², A. Konvalinka¹
¹Toronto General Hospital Research Institute and UHN Transplant Centre, UHN, Toronto, ON, Canada, ²Toronto General Hospital Research Institute, Dept. of Immunology, UHN Transplant, Toronto, ON, Canada
*Purpose:Understanding the molecular profiles and individual contributions of kidney parenchymal and resident/infiltrating immune cells during homeostasis would facilitate development of treatments for kidney graft disease.…
2020 American Transplant Congress
Role of Cross-Dressing in Kidney Transplantation
D. Zhao, R. Tieu, K. Abou-Daya, A. Williams, M. Oberbarnscheidt, F. Lakkis
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Activation of host T cells that mediate allograft rejection is relied on dendritic cells (DCs) presenting alloantigens to T cells. Our recent study revealed…
2020 American Transplant Congress
Waitlist-Conditioned Transplant Rate is Not an Appropriate Metric for Benchmarking Access to Kidney Transplantation
D. Anderson, H. Qu, P. MacLennan, M. Mustian, R. Reed, A. C. Kale, B. Orandi, B. Shelton, V. Kumar, J. Locke, M. Hanaway
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Transplant rate is used as a primary metric of center performance as reported by the SRTR. However, the calculation of transplant rate can be…
2020 American Transplant Congress
Analysis of Rejection, Rejection Therapy and Renal Function in the BEST Trial
H. Kuzaro¹, A. R. Shields², A. Wiseman³, S. Tremblay¹, A. Christianson¹, D. Kaufman⁴, J. Leone⁵, A. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Colorado, Denver, CO, ⁴U Wisconsin, Madison, WI, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷UIC, Chicago, IL
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal) compared two belatacept (BELA)-based early corticosteroid withdrawal (ESW) regimens and alemtuzumab (ALEM) or rabbit antithymocyte globulin (rATG)…
2020 American Transplant Congress
Totally Robotic Living Donor Hepatectomy Graft Parenchymal Transection Time
Y. L. Cheah, J. Kim, C. J. Simon, S. Meade, R. Jenkins, M. E. Akoad
Lahey Hospital & Medical Center, Burlington, MA
*Purpose: Evaluate duration of parenchymal transection in a series of totally robotic living donor hepatectomies in order to improve time coordination between living donor and…
2020 American Transplant Congress
Racial/Ethnic Differences in Deceased Organ Donor Rates Over Time in the United States
A. Kernodle, W. Zhang, B. Doby, L. Liyanage, A. Massie, T. Purnell, D. Segev
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Historically, deceased organ donation rates have varied across racial/ethnic groups within the US. To address these differences, the transplant community has investigated select minority…
2020 American Transplant Congress
Role of CAR-T Cell Therapy in Post Transplant Lymphoproliferative Disorder
S. Krishnamoorthy, A. Malone, R. Delos Santos, H. Murad, T. Alhamad
Transplant, Washington University in St. Louis, Saint Louis, MO
*Purpose: Chimeric Antigen Receptor (CAR) T cells are a genetically modified autologous immunotherapy that uses a patient’s own T cells modified with a chimeric antigen…
2020 American Transplant Congress
Increased Mitochondrial Metabolic Enzymes are Associated with Superior Kidney Function after Normothermic Ex-Vivo Kidney Perfusion-A Proteomics Study
C. McEvoy¹, S. Clotet-Freixas¹, T. Tokar², C. Pastrello², S. Reid³, I. Batruch⁴, A. RaoPeters⁵, P. Urbanellis¹, M. Kaths¹, S. Farkona¹, J. Van³, B. Urquhart⁵, I. Jurisica², L. Robinson⁶, M. Selzner¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute and Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Dept. of Laboratory Medicine and Pathobiology Institute, UHN, Toronto, ON, Canada, ⁵Schulich School of Medicine & Dentistry, UWO, London, ON, Canada, ⁶The Hospital for Sick Children Research Institute, Toronto, ON, Canada
*Purpose: Kidneys donated after circulatory death (DCD) contribute significantly to the donor pool, but have inferior outcomes. Normothermic ex-vivo kidney perfusion (NEVKP) results in significantly…
2020 American Transplant Congress
Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival
A. J. Matar, B. P. Lovasik, S. C. Kim, C. A. Breeden, D. A. Faber, D. V. Mathews, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…
2020 American Transplant Congress
Outcomes of Successive Pregnancies in Kidney Transplant Recipients
S. Rao¹, L. Coscia², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Heath System, Charlottesville, VA, ²Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: Pregnancy after transplant is considered high risk; nevertheless female kidney transplant (KT) recipients may have several post-transplant pregnancies. The aim of this study was…