ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Development of a Novel Multidrug Combination to Defat Steatotic Rat Liver via Normothermic Machine Perfusion

    M. Xu1, F. Zhou1, O. Ahmed1, G. Upadhya1, J. Jia1, C. Lee1, J. Xing1, L. Ye1, S. Shim1, Z. Zhang1, K. Byrnes2, B. Wong1, J. Kim1, Y. Lin1, W. Chapman1

    1Surgery, Washington University, St. Louis, MO, 2Pathology and Immunology, Washington University, St. Louis, MO

    *Purpose: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies (Yarmush et al., Y defatting) have successfully reduced the…
  • 2020 American Transplant Congress

    Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation

    H. Yamane, Y. Tanaka, M. Ohira, H. Tahara, K. Ide, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, a member of the B7/CD28 family, triggers an immune checkpoint resulting in inhibition of T cells. Several…
  • 2020 American Transplant Congress

    Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation

    S. B. See1, B. S. Mantell2, K. J. Clerkin3, B. Ray4, E. R. Vasilescu5, C. Marboe5, Y. Naka6, S. Restaino3, P. C. Colombo3, L. Addonizio2, M. A. Farr3, E. Zorn1

    1Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 2Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, 3Department of Medicine, Columbia University Irving Medical Center, New York, NY, 4Research and Development, Immucor, Waukesha, WI, 5Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 6Department of Surgery, Columbia University Irving Medical Center, New York, NY

    *Purpose: Antibody-mediated rejection (AMR) driven by the development of donor-specific antibodies (DSA) directed against mismatched donor HLA is a major risk factor for graft loss…
  • 2020 American Transplant Congress

    CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel

    N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan

    Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…
  • 2020 American Transplant Congress

    Everolimus-Treatment Inhibits the Transition of the Immature Subsets of Liver Natural Killer Cells to Mature State and Enhances Anti-Tumor Activity

    Y. Tanaka, J. Saparbay, H. Ohdan

    Gastreenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation efficiently reduces the adaptive immune components. During suppressed adaptive immunity, the innate immune cells may play…
  • 2020 American Transplant Congress

    HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol

    C. Garcia-Sanchez1, V. Kosmoliaptsis2, H. Copley2, J. Leventhal1, S. Ildstad3

    1NU, Chicago, IL, 2Cambridge, Cambridge, United Kingdom, 3U of Louisville, Lousville, KY

    *Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…
  • 2020 American Transplant Congress

    Belatacept Monthly Therapy: Transplant Recipients’ Experience

    S. N. Little1, É. N. Arsenault Knudsen2, D. A. Mandelbrot1

    1Transplant, University of Wisconsin Hospital and Clinics, Madison, WI, 2University of Wisconsin Hospital and Clinics, Madison, WI

    *Purpose: While graft and patient outcomes with belatacept have been relatively well documented, the decision to use belatacept for kidney transplant recipients rests in part…
  • 2020 American Transplant Congress

    A Multicenter, Randomized, Controlled Trial to Steer Immunosuppressive Therapy by Virus-Specific T Cells after Pediatric Kidney Transplantation (IVIST-Trial)

    T. Ahlenstiel-Grunow1, A. Großhennig1, R. Schild2, J. Oh2, C. Taylan3, L. Weber3, H. Staude4, M. Verboom1, C. Schröder1, R. Sabau1, A. Koch1, X. Liu1, L. Pape1

    1Hannover Medical School, Hannover, Germany, 2University Hospital Hamburg-Eppendorf, Hamburg, Germany, 3University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany, 4University Hospital of Rostock, Rostock, Germany

    *Purpose: Pharmakokinetic monitoring of immunosuppressants alone is insufficient to estimate the individual intensity of immunosuppression after kidney transplantation (Tx). Virus-specific T cells (Tvis) correlate with…
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