2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…2020 American Transplant Congress
ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level
Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…2020 American Transplant Congress
A Video Education Intervention to Improve Kidney Transplant Knowledge and Willingness to Complete Transplant Evaluation in Dialysis Patients
*Purpose: The Centers for Medicare and Medicaid Services has set a goal of 30% (currently 18.5%) of dialysis patients to be on a transplant (Tx)…2020 American Transplant Congress
The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation
Columbia University Medical Center, New York, NY
*Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…2020 American Transplant Congress
Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis
*Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…
American Transplant Congress abstracts