2020 American Transplant Congress
Humanized Mouse Reveals the Cytoprotective Function of Hepatocyte RXFP1 in Liver Transplant Recipients
*Purpose: RXFP1 (RLX family peptide receptor 1) is a cognate receptor for relaxin (RLX), an insulin-like growth factor, with vasoactive/remodeling properties. We have documented cytoprotective…2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…2020 American Transplant Congress
Financial Analysis of Donor HCV+ Kidney in HCV- Recipients
*Purpose: Use of organs from viremic hepatitis C positive donors (dHCV+) in recipients without HCV has been demonstrated to improve access to kidney transplant (KTx).…2020 American Transplant Congress
Early Inflammatory Lesions on Surveillance Biopsies Post Kidney Transplant is Associated with Increased Incidence of Late Clinical Rejections
*Purpose: It is unclear whether subclinical inflammation (or subclinical rejection) noted on early post transplant biopsies are associated with late clinical rejections (beyond 6 months).*Methods:…2020 American Transplant Congress
Cross-Validation of Performance-Based Frailty against Daily Step Count from Personal Activity Trackers – Refining Prehabilitation Tools in Liver Transplant Candidates
*Purpose: The AST proposed a toolkit to identify frailty in liver transplant (LT) candidates, including the liver frailty index (LFI) and 6-min walk test (6MWT).…2020 American Transplant Congress
Role of Peptide Antigen, Antigen-Presenting Cells and CD4 T Cells in Modulating BK Polyomavirus (BKPyV)-Specific CD8 T Cell Responses In Vitro
Biomedicine, University of Basel, Basel, Switzerland
*Purpose: BKPyV persists as significant cause of premature kidney transplant failure. Current treatment is based on reducing immunosuppression to regain immune control over BKPyV replication…2020 American Transplant Congress
New and Unknown: VCA Acceptability to the General Public
Social and Behavioral Sciences, Temple University, Philadelphia, PA
*Purpose: Despite the promise of vascularized composite allotransplantation (VCA) as a viable alternative to available reconstructive procedures or prosthetics, its future relies heavily on families’…2020 American Transplant Congress
Renal Allograft Surveillance with Allospecific T-cytotoxic Memory Cells Which Express CD154
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Allo-antigen-specific T-cytotoxic memory cells (TcM) which express CD40 ligand (CD154) in overnight lymphocyte co-culture are strongly associated with acute cellular rejection (ACR) seen in…2020 American Transplant Congress
Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…2020 American Transplant Congress
Pilot Donor App Users Maintain Higher Transplant Rates Than Matched Controls
Johns Hopkins University, Baltimore, MD
*Purpose: We previously conducted a pilot study demonstrating that patients who used the Donor App (DA) were 6.6 times more likely to generate a live…
American Transplant Congress abstracts