ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Lifetime Survival Estimates Following Solid Organ Transplantation in the United States

    C. Graham1, M. Skeans2, Y. Ahn2, C. Watson3, A. Barlev4

    1RTI Health Solutions, Research Triangle Park, NC, 2Chronic Disease Research Group, Minneapolis, MN, 3Atara Biotherapeutics, South San Francisco, CA, 4Atara Biotherapeutics, Thousand Oaks, CA

    *Purpose: The Scientific Registry of Transplant Recipients (SRTR) contains detailed patient and graft survival data for all solid organ transplants (SOT) in the United States…
  • 2020 American Transplant Congress

    Assessment of Sarcopenia and Obesity by Bioelectrical Impedance Analysis in Transplant and Hepatobiliary Populations

    J. Konel1, T. Kitajima2, L. Arevalo1, N. Murray1, T. Pietrowsky2, D. Venkat2, H. Gonzalez2, M. Samaniego2, M. Abouljoud2, S. Nagai2

    1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

    *Purpose: Sarcopenia and obesity are common among transplant and hepatobiliary patients; however, current methods of measuring these risk factors may provide an inadequate representation of…
  • 2020 American Transplant Congress

    Implications for Facilitated Pancreas Transplant Allocation with the Removal of Donor Service Area

    R. Forbes1, R. Urban2, A. Fox2, J. Odorico3, S. Niederhaus4

    1Vanderbilt University Medical Center, Nashville, TN, 2United Network for Organ Sharing, Richmond, VA, 3University of Wisconsin, Madison, WI, 4University of Maryland, Baltimore, MD

    *Purpose: Facilitated Pancreas (FP) Allocation, modified in August 2016 to be metric-based rather than opt-in, defines an eligible center as one that has transplanted at…
  • 2020 American Transplant Congress

    Uncovering Factors That Lead to an Increase in Significant Early Rejection Outcomes in Cardiac Transplant Patients

    N. Parimi1, J. Titterington2

    1Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 2Cardiovascular Disease, University of Kansas Health System, Kansas City, KS

    *Purpose: The factors that lead to an increase in significant early rejection (stage 2R or greater) along with the preferred induction immunosuppression strategy in orthotopic…
  • 2020 American Transplant Congress

    Wait Times in Pediatric Heart Transplant Candidates: Impact of Size and Blood Type Following the 2016 Allocation Policy Revision

    R. J. Williams, M. Lu, L. A. Sleeper, S. Urbach, K. P. Daly

    Department of Cardiology, Boston Children's Hospital, Boston, MA

    *Purpose: To describe wait times for pediatric heart transplant (HT) candidates following institution of a new allocation system in March 2016.*Methods: The OPTN database was…
  • 2020 American Transplant Congress

    The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation

    A. Hitz1, R. Bellmàs Sanz1, F. Ius2, J. Kühne1, B. Wiegmann2, W. Sommer2, J. Salman2, T. Siemeni2, C. Kühn2, M. Avsar2, A. Haverich2, I. Tudorache2, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
  • 2020 American Transplant Congress

    Multicenter Evaluation of Cytomegalovirus Infection Following Intestinal and Multivisceral Transplantation

    M. Segovia1, Y. Patel1, S. Nagai2, D. Sudan1, S. Jafri2

    1Duke University Hospital, Chapel Hill, NC, 2Henry Ford Hospital, Detroit, MI

    *Purpose: Evaluate factors related to incidence and outcomes of cytomegalovirus (CMV) infection after isolated intestinal transplantation (IT) and multivisceral transplantation (MVT).*Methods: Retrospective evaluation of 32…
  • 2020 American Transplant Congress

    Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, L. Kamal1, A. King1, L. Kang1, M. Levy1, S. Bobba1, D. Massey1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
  • 2020 American Transplant Congress

    microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…
  • 2020 American Transplant Congress

    Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model

    R. Schmitz, M. S. Mulvihill, Z. W. Fitch, T. How, F. Leopardi, A. D. Kirk

    Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Lymphocyte depletion and subsequent homeostatic repopulation present opportunities to shape the alloreactive immune repertoire to favor tolerance. We tested if the addition of thymic…
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