Am J Transplant, Volume 20, Suppl 3 Archives - Page 217 of 223 - ATC Abstracts

2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
J. Buggs¹, J. Zhang², J. Wei², L. Wang²
¹Transplant Surgery, Tampa General Hospital, Tampa, FL, ²Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…
2020 American Transplant Congress
Gut-Restricted Microbiota Can Affect Outcome of Distal Skin Grafts
M. Sepulveda¹, L. Chen¹, Y. Wang¹, J. Park¹, Z. Early¹, B. Jabri², A. Chong³, M. Alegre¹
¹Medicine, University of Chicago, Chicago, IL, ²Pathology, University of Chicago, Chicago, IL, ³Surgery, University of Chicago, Chicago, IL
*Purpose: The communities of microorganisms that colonize barrier surfaces, termed the microbiota, are environmental agents that can influence the maturation and function of the immune…
2020 American Transplant Congress
Outcomes Analysis of Transplant Centers Performing High Volumes of Hard to Place Kidneys: An Update
D. Bahl¹, N. Mehta², Y. A. Qazi³
¹School of Medicine, St. George's University, West Indies, Grenada, ²University of California, Berkeley, Torrance, CA, ³School of Medicine, Keck Medicine of USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, the discard rate remains significantly high. The UNOS SRTR data now provides information on…
2020 American Transplant Congress
Donor Derived Cell Free DNA (dd-cfDNA) and Gene Expression Signatures of Antibody-Mediated Rejection (ABMR) May Improve Accuracy of ABMR Diagnosis (Dx)
H. Zhang¹, C. C. Nast², E. Huang³, N. Ammerman³, A. A. Vo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Dd-cfDNA has a clinically meaningful association with early Dx of ABMR. Here, we evaluated dd-cfDNA measured prior to for-cause biopsies (Bx), and also measured…
2020 American Transplant Congress
Long-Term Pediatric Outcomes of Simultaneous vs. Sequential Liver-Kidney Transplantation: A Review of the UNOS Database
K. Goli¹, A. Rana¹, J. Goss¹, T. Miloh²
¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ²University of Miami, Houston, TX
*Purpose: The long-term pediatric outcomes of simultaneous liver-kidney (SLK) transplantation and sequential liver and kidney transplantation, liver after kidney (LAK) and kidney after liver (KAL),…
2020 American Transplant Congress
Unrealized Potential Utilization of HCV+ Deceased-Donor Kidneys and Livers
A. Massie, C. Durand, N. Desai, W. El-Nahal, D. Segev
Johns Hopkins, Baltimore, MD
*Purpose: In the era of new, direct-acting antiviral therapy for hepatitis C virus (HCV), HCV+ deceased-donor organs can be transplanted into HCV- recipients with excellent…
2020 American Transplant Congress
Distribution of High-Urgency Listing and Regional Variation before and after Implementation of the 2018 US Heart Allocation Policy
T. Cascino¹, M. Skeans², V. Patel¹, M. Colvin¹
¹University of Michigan, Ann Arbor, MI, ²SRTR, Minneapolis, MN
*Purpose: The demand for heart transplant exceeds organ availability. The Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) updated heart allocation policy in…
2020 American Transplant Congress
Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression
T. Sigdel, A. Schroeder, J. Y. Yang, R. Sarwal, J. Liberto, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: The purpose of this study was to apply high-throughput metabolomics and machine learning to identify surrogate urine metabolite biomarkers for acute rejection vs. BK…
2020 American Transplant Congress
Endothelial Cells Internalize Apoptotic Exosome-Like Vesicles Through Phosphatidylserine-Dependent Macropinocytosis
F. Migneault, M. Dieudé, A. Brodeur, N. Thibodeau, D. Beillevaire, M. Hébert
CRCHUM, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion and rejection favor endothelial apoptosis, which in turn contributes to maladaptive vascular repair leading to transplant vasculopathy. Apoptotic endothelial cells (EC) release exosome-like…
2020 American Transplant Congress
Acute Kidney Injury in Deceased Organ Donors and Kidney Transplant Outcomes Using a Novel Data Source
E. M. Sonnenberg, J. Hsu, J. Cohen, V. Potluri, M. H. Levine, P. L. Abt, P. P. Reese
Perelman School of Medicine, University of Pennsyl, Philadelphia, PA
*Purpose: The kidney shortage necessitates innovative approaches to expand the donor pool. Acute kidney injury(AKI) is common among deceased donors and a risk factor for…