Am J Transplant, Volume 20, Suppl 3 Archives - Page 211 of 223 - ATC Abstracts

2020 American Transplant Congress
Anticipated Cost Savings of Using Lungs from Hepatitis C-Positive Lung Donors for Hepatitis C-Negative Recipients
K. Ryland¹, J. Mallea², J. Moriarty³, L. White⁴, B. Borah⁵, J. Naessens³
¹Transplantation, Mayo Clinic, Jacksonville, FL, ²Medicine, Mayo Clinic, Jacksonville, FL, ³Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research, Mayo Clinic, Jacksonville, FL, ⁵Health Sciences Research, Mayo Clinic, Rochester, MN
*Purpose: We assessed the cost savings generated by additional organ availability due to utilizing lungs from hepatitis-C infected donors for transplantation in comparison to existing…
2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
T Cell Activation by Allogeneic EVs and Allogeneic MHC Cross-Dressed Cells In Vitro and In Vivo
A. Prunevieille¹, B. Gonzalez-Nolasco¹, G. Benichou¹, N. Mooney², A. Colleen³
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²INSERM, Paris, France, ³Boston College, Boston, MA
*Purpose: The recognition of donor-MHC molecules by recipient T cells triggers the immune response leading to rejection of allografts. Our recent studies have documented the…
2020 American Transplant Congress
Consequences of Turning Down High KDPI Kidney Organ Offers for Kidney Transplant Candidates
J. D. Motter, L. Liyanage, K. R. Jackson, M. G. Bowring, T. Ishaque, Y. Yu, S. Yu, J. M. Garonzik-Wang, A. B. Massie, D. L. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: Kidneys with a high Kidney Donor Profile Index (KDPI, 80-100%) are frequently declined as they are associated with higher graft loss; yet, candidates that…
2020 American Transplant Congress
Change In i-IFTA Associated with Treatment of Rejection
N. Garg, B. C. Astor, S. Parajuli, F. Aziz, M. Mohamed, W. Zhong, A. Djamali, D. A. Mandelbrot
UW-Madison, Madison, WI
*Purpose: Recent studies have shown that inflammation in areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with worse kidney allograft outcomes. How i-IFTA…
2020 American Transplant Congress
Hepatic Artery Reconstruction in Living Donor Liver Transplantation Using Surgical Loupes: Achieving Low Rate of Hepatic Arterial Thrombosis in Consecutive 1000 Recipients- Tips and Tricks to Overcome the Poor Hepatic Arterial Flow
A. Thorat, L. Jeng, S. Hsu, P. Li, H. Yang, T. Chen, K. Poon
Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan
*Purpose: The reconstruction of hepatic artery (HA) is most complex step in living donor liver transplantation (LDLT) due to smaller diameter of the artery and…
2020 American Transplant Congress
Process Matters: Factors in Refusing Solid Organ Donation by African Americans
L. A. Siminoff¹, G. P. Alolod¹, H. M. Gardiner¹, R. D. Hasz², P. A. Mulvania², M. Wilson-Genderson¹
¹Social and Behavioral Sciences, Temple University, Philadelphia, PA, ²Gift of Life Donor Program, Philadelphia, PA
*Purpose: With approximately 25 African Americans (AAs) dying weekly while awaiting a transplantable organ, this study compares the experiences of AA families who authorized donation…
2020 American Transplant Congress
Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation
J. D. Fisher¹, W. Zhang², S. C. Balmert³, A. M. Aral¹, Y. Kulahci⁴, A. P. Acharya⁴, J. Li², H. R. Turnquist⁵, A. W. Thomson⁵, M. G. Solari², V. S. Gorantla⁶, S. R. Little⁴
¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, ²Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, ³Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Bioengineering, Wake Forest University, Winston-Salem, NC
*Purpose: Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive drugs to prevent rejection.*Methods:…
2020 American Transplant Congress
New Strategy to Maximize Nanomedicine Delivery During Ex Vivo Organ Perfusion
C. Albert¹, L. Bracaglia¹, A. Koide², C. M. Edwards³, T. Lysyy³, J. S. Pober⁴, M. Saltzman¹, S. Koide², G. Tietjen³
¹Biomedical Engineering, Yale University, New Haven, CT, ²Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, ³Surgery, Yale University, New Haven, CT, ⁴Immunobiology, Yale University, New Haven, CT
*Purpose: Organ transplant is a highly successful therapy for patients facing end stage organ failure. However, there is a severe lack of transplantable organs which…
2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…