Am J Transplant, Volume 20, Suppl 3 Archives - Page 210 of 223 - ATC Abstracts

2020 American Transplant Congress
A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization
J. Lan¹, J. S. Gill¹, H. M. Gebel², R. A. Bray², R. Liwski³, A. Vinson⁴, A. Greenshields³, S. Dobrer⁵, O. Gunther⁵, K. Sherwood⁵, F. H. Claas⁶, S. Heidt⁶, G. Karahan⁶, J. Gill⁷, M. Gill¹, U. Varyani¹, P. Jindal¹, P. Keown⁵
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA, ³Pathology, Dalhousie University, Halifax, NS, Canada, ⁴Nephrology, Dalhousie University, Halifax, NS, Canada, ⁵Pathology, University of British Columbia, Vancouver, BC, Canada, ⁶Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands, ⁷Nephrology, Emory University, Atlanta, GA
*Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…
2020 American Transplant Congress
Does Recovery Rate of Renal Plasma Flow after Kidney Transplantation Differ in the Choice of Renal Arterial Anastomotic Site?
T. Yonekura, K. Shinoda, K. Nishikawa, M. Maeda, H. Oguchi, Y. Hidaka, T. Mizutani, K. Sakurabayashi, M. Muramatsu, T. Kawamura, K. Sakai, S. Shishido
Toho University, Ota, Japan
*Purpose: Acquiring better inflow and recovery of blood supply to the renal graft is very critical in clinical kidney transplantation. Whether inflow to the renal…
2020 American Transplant Congress
Validity and Utility of Urinary CXCL10/Cr Monitoring in Pediatric Kidney Transplant Recipients
T. Blydt-Hansen¹, A. Sharma², I. Gibson², C. Weibe², A. Sharma³, V. Langlois⁴, C. Teoh⁴, D. Rush², P. Nickerson², D. Wishart⁵, J. Ho²
¹University of British Columbia, Vancouver, BC, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Western Ontaria, London, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Alberta, Edmonton, AB, Canada
*Purpose: Effective post-transplant monitoring is hampered by a lack of effective biomarkers. We sought to validate the utility of urinary CXCL10/Cr monitoring of rejection in…
2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
B. Kim¹, E. Kim², J. Kim², H. Choi³, H. Lee², J. Lee⁴, M. Kim⁴, Y. Kim⁴, K. Huh⁴
¹Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
2020 American Transplant Congress
Antibiotic Pretreatment Alleviates Liver Transplant Damage by Modulating the Composition of Commensal Microbiota
K. J. Dery, S. Kageyama, H. Hirao, K. Kadono, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The human intestinal microbiome contains more than 100 trillion commensal microorganisms, exceeding the number of cells in the human body by 10-fold. Although recent…
2020 American Transplant Congress
IL-21, a Potential Target of Active Rejection in Renal Transplantation
J. Shen, R. Wang, L. Guo, J. Lv, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Rejection remains an obstacle to overcome after transplantation. IL-21 is the most potent stimulators of driving GC B cells into plasma cells. Basic researches…
2020 American Transplant Congress
Impact of Liver Graft Preservation Methods on the Gut Microbiome and Metabolome
G. A. Cresci¹, N. Sangwan², A. Simioni³, Q. Liu³, C. Quintini³
¹Pediatric Gastroenterology and Inflammation & Immunity, Cleveland Clinic, Cleveland, OH, ²Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ³Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex-vivo liver perfusion (NEVLP) is a powerful platform for organ preservation and assessment. It induces metabolic reactivation that potentially helps clear accumulated toxic…
2020 American Transplant Congress
Routine Human Renal Allograft Biopsies Analyzed for mRNA Content with a Novel Nanostring mRNA Human Organ Transplant (HOT) Panel
I. Rosales¹, R. Smith¹, E. Acheampong¹, T. Kawai¹, T. Tsuji², K. Hotta³, R. Colvin¹
¹Massachusetts General Hospital, Boston, MA, ²Sapporo City General Hospital, Sapporo, Japan, ³Hokkaido University Hospital, Sapporo, Japan
*Purpose: In 2019 a Banff Working Group and Nanostring Technologies developed a panel of 770 mRNA probes for assessment of human organ allografts, based on…
2020 American Transplant Congress
Rabbit Anti-Thymocyte Globulin versus Anti-T Lymphocyte Globulin Rescue Therapies in Delayed Graft Function after Kidney Transplantation from Donors after Cardiac Death
H. Yang¹, Y. Shi², X. Li¹, C. Long¹, H. Li³, Z. Wang³
¹Department of Organ Transplantation, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Delayed graft function (DGF) is common in recipients of kidney transplants from donation after cardiac death (DCD) donors, induction therapy with monoclonal or polyclonal…
2020 American Transplant Congress
Increased Graft Survival Following Implementation of the Kidney Allocation Score
M. L. Samoylova¹, B. I. Shaw¹, W. Irish², S. J. Kesseli¹, A. Connor¹, A. S. Barbas¹, L. McElroy¹, K. V. Ravindra¹
¹Surgery, Duke University Hospital, Durham, NC, ²Surgery, East Carolina University, Greenville, NC
*Purpose: The Kidney Allocation Score (KAS) was developed to improve matching of donor and recipients; we examine the effect of this change on transplantation practice…