Am J Transplant, Volume 20, Suppl 3 Archives - Page 193 of 223 - ATC Abstracts

2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats
P. Narayan, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
2020 American Transplant Congress
Targeting CD4⁺ T Cell Metabolism Prolongs Graft Survival Age-Specifically
Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Harvard Medical School, Boston, MA
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…
2020 American Transplant Congress
Identification of Cell Types That Harbor Cytomegalovirus DNA in Acutely and Latently Infected Mice Spleen
A. S. Maganti¹, X. Liu², M. Abecassis²
¹Illinois Math and Science Academy, Aurora, IL, ²Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: Cytomegalovirus (CMV) is a ubiquitous β‐herpesvirus that infects majority of humans. Primary CMV infection may be asymptomatic or manifests as a self‐limited febrile illness…
2020 American Transplant Congress
Adaptive Induction Therapy in Renal Transplant Recipients (RTR) with Donor-Specific Antibody (DSA)
K. Linhares¹, M. Cristelli², R. De Marco³, L. Viana², C. Felipe², M. Tavares², C. Peixoto², G. Marcello², J. Toniato², K. Ficher², L. Villanueva², L. Villanueva², M. De Lima³, J. Pestana², H. Tedesco Jr.²
¹Nephrology Division, Hospital do Rim, Sao Paulo, Brazil, ²Nephrology Division, Hospital Do Rim, Sao Paulo, Brazil, ³Histocompatibility Laboratory, Instituto De Imunogenética IGEN, Sao Paulo, Brazil
*Purpose: Patients with preformed DSA are at higher risk of developing acute antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: We analyzed consecutive kidney transplant recipients (RTR)…
2020 American Transplant Congress
Short Tandem Repeat (STR) Analysis Identifies a Cancer Transmitted from an Organ Donor to 4 Transplant Recipients
M. Park¹, J. Van Ziffle¹, E. Collisson¹, J. Grenert¹, S. Behr¹, A. Gonzalez¹, J. Chou¹, S. Maisel¹, T. Friedlander¹, C. Freise¹, J. Shoji¹, T. Semrad², P. Chin-Hong¹, C. Atreya¹
¹UCSF, San Francisco, CA, ²Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, CA
*Purpose: Organ donors are systematically screened for infection, while screening for malignancy is less rigorous. The true incidence of donor-transmitted malignancies is unknown due to…
2020 American Transplant Congress
The Influence of Donor Kidney to Recipient Body Weight Ratio on Long-Term Outcomes of Living-Donor Kidney Transplantation
N. Sato, Y. Kakuta, T. Kanzawa, K. Unagami, M. Okumi, H. Ishida, K. Tanabe
Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
*Purpose: We often experience the incompatibility in size between the kidney graft and recipient in living-donor kidney transplantation. This study evaluated the effect of the…
2020 American Transplant Congress
IgA Nephropathy Outcomes after Kidney Transplantation in an Early Corticosteroid Withdrawal Center
S. Kurian¹, S. Spierling², B. Barrick¹, J. Rice¹, J. Case¹, C. Marsh¹
¹Scripps Center for Organ and Cell Transplantation, La Jolla, CA, ²Scripps Whittier Diabetes Institute, La Jolla, CA
*Purpose: IgA nephropathy (IgAN) is the most frequent biopsy-proven primary glomerular disease. Recurrent IgA after transplantation often leads to allograft loss. A lower risk of…
2020 American Transplant Congress
Tele Health Utilization in Kidney Transplantation Clinic
S. Wattanatorn, S. Udomkarnjananun, N. Townamchai, T. Thammathiwat, N. Mahatanan, Y. Avihingsanon, K. Praditpornsilpa
Chulalongkorn University, Bangkok, Thailand
*Purpose: Most of the kidney transplanted (KT) patients are well educated and have been receiving nearly the same medications every visit. In usual OPD care,…
2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, M. Chu¹, A. D. Guzman¹, E. D. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
2020 American Transplant Congress
De Novo Dosing and Trough Attainment Trends of Extended-Release Tacrolimus in the Absence of Dose Adjustments
M. J. Moritz¹, D. R. Stevens², U. Meier-Kriesche², T. A. Horwedel²
¹Department of Surgery, Lehigh Valley Health Network, Allentown, PA, ²Veloxis Pharmaceuticals, Cary, NC
*Purpose: Initial dosing of tacrolimus extended-release tablets (LCPT) was 0.17 mg/kg/day in the pivotal trial in de novo kidney transplant recipients. Dosing subsequent to the…