2020 American Transplant Congress
Pancreas Transplants in Asian Recipients
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Over the years, a change in patients receiving a pancreas transplant could be observed. While in the beginning the standard pancreas transplant recipient was…2020 American Transplant Congress
Donor-Derived Cell-Free DNA Kinetics in Stable Kidney Transplant Patients Are Related to Donor/Recipient Variables
Intermountain Medical Center, Murray, UT
*Purpose: Donor-derived cell free DNA (dd-cfDNA) is increasingly used to monitor for allograft rejection. The relationship of dd-cfDNA to donor and recipient variables in not…2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…2020 American Transplant Congress
Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2020 American Transplant Congress
Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model
*Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…2020 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…2020 American Transplant Congress
Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…2020 American Transplant Congress
A Novel Immunoresponse Monitoring System to Predict Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
1Hokkaido University, Sapporo, Japan, 2Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody mediated rejection (CAAMR) induced by de novo donor specific antibodies (DSA) is the main cause of graft loss in the long-term.…2020 American Transplant Congress
Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice
1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…2020 American Transplant Congress
Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell
*Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
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