Am J Transplant, Volume 20, Suppl 3 Archives - Page 183 of 223 - ATC Abstracts

2020 American Transplant Congress
Kidneys from AKI Donors with Poor Long-Term Outcomes Present an Impaired Protein Expression for Cellular Stress and Repair
F. Neri¹, M. Lo Faro¹, C. Boffa¹, T. Surik¹, M. Kaisar¹, E. J. Sharples², J. P. Hunter¹, J. Lindeman³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, ²Oxford Transplant Centre, Oxford, United Kingdom, ³Department of Vascular Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands
*Purpose: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was…
2020 American Transplant Congress
A Monocyte-Derived MicroRNA Signature for Antibody-Mediated Rejection in Kidney Transplantation
C. Tinel¹, B. Lamarthée¹, F. Von Tokarski¹, M. Rabant², C. Legendre¹, W. Gwinner³, M. Naesens⁴, P. Marquet⁵, D. Anglicheau¹
¹Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, ²Pathology, Necker Hospital, Paris, France, ³Nephrology, Hannover Medical School, Hannover, Germany, ⁴Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium, ⁵Nephrology, Dialysis and Transplantation, Inserm U850, Limoges University Hospital, Limoges, France
*Purpose: MicroRNAs (miRNAs) are small noncoding RNAs which regulate mRNA expression at the posttranscriptional level. We investigated blood miRNAs as non-invasive biomarkers in kidney transplantation…
2020 American Transplant Congress
Kidneys from Pediatric Donors Are Preferentially Allocated to Adult Highly Sensitized and Not to Pediatrics Under the New Kidney Allocation System (KAS)
D. Puliyanda¹, H. Pizzo¹, J. Garrison¹, S. Williamson², I. Kim², E. Huang²
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: In 12/2014, the new Kidney Allocation System (KAS) assigned allocation priority to highly sensitized (HS) recipients while maintaining access to donors for pediatric patients…
2020 American Transplant Congress
Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) Are Beneficial to Clarifying ABMR Activity in Ambivalent Cases
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, I. Gallegos³, M. Arevalo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: “Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Here, we…
2020 American Transplant Congress
The Natural History of Waitlist Candidates in the United States
A. Massie¹, D. Segev²
¹Johns Hopkins School of Medicine, Baltimore, MD, ²Johns Hopkins, Baltimore, MD
*Purpose: Estimates of time to deceased-donor transplantation (DDKT) generally fail to take into account the competing risks of mortality. Understanding the natural history of KT…
2020 American Transplant Congress
Survey of Clinician Opinions on Use of Organ Transplants from Hepatitis C Virus Positive Donors: Identifying & Overcoming Barriers
K. Lentine¹, T. Alhamad², D. Peipert³, Y. Caliskan¹, B. Concepcion⁴, R. Forbes⁴, M. Schnitzler¹, Z. Zhang¹, S. Chang², M. Cooper⁵, R. Bloom⁶, R. Mannon⁷, D. Axelrod⁸
¹Saint Louis U, Saint Louis, MO, ²Washington U, Saint Louis, MO, ³Northwestern, Chicago, IL, ⁴Vanderbilt, Nashville, TN, ⁵Georgetown, Washington, DC, ⁶U Penn, Philadelphia, MO, ⁷UAB, Birmingham, AL, ⁸U Iowa, Iowa City, IA
*Purpose: Increasing the use of Hepatitis C Virus (HCV) viremic (Nucleic Acid Testing (NAT)+) donor organs for HCV uninfected (HCV-) patients is a potential approach…
2020 American Transplant Congress
Utilization of Mechanical Circulatory Support Devices and Impact on Outcomes in the New Heart Allocation System: An Analysis of the UNOS Registry
L. K. Truby¹, M. Farr², E. M. DeFilippis³, K. Takeda³, V. K. Topkara³
¹Duke University Medical Center, Durham, NC, ²Columbia University Irving Medical Center, New York City, NY, ³Columbia University Irving Medical Center, New York, NY
*Purpose: In October 2018, a new heart transplantation allocation system was put into effect with the intent of better stratifying the most medically urgent candidates,…
2020 American Transplant Congress
A Comparison of Temporal Gene Expression Patterns in Kidney, Heart, Liver, and Lung Transplant Biopsies
P. Halloran¹, J. Reeve¹, .. the INTERLUNG Study Group², .. the INTERHEART Study Group², .. the INTERLIVER Study Group², &. the INTERCOMEX Study Group²
¹University of Alberta, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Gene expression patterns change with time post-transplant. The MMDx system makes it possible to do cross-organ comparisons using the same microarray platform and gene…
2020 American Transplant Congress
Clinical Outcomes from a Mobile Health, Pharmacist-Led Intervention: 12-Month Results of the Transafe Rx Randomized Controlled Trial
D. Taber, J. Hirsch, Z. Su, J. McGillicuddy, A. Posadas, J. Fleming
Med Univ of South Carolina, Charleston, SC
*Purpose: Medication errors and non-adherence are predominant causes of poor graft outcomes in kidney transplant (KTX) recipients. The primary aim of the TRANSAFE Rx RCT…
2020 American Transplant Congress
Temporal Trends in Utilization and Outcomes of Sclerotic Donor Kidneys in the United States
J. D. Motter, K. R. Jackson, J. J. Long, A. B. Massie, N. M. Desai, D. L. Segev, J. M. Garonzik-Wang
Johns Hopkins University, Baltimore, MD
*Purpose: Sclerotic donor kidneys (SDK, glomerulosclerosis ≥20% on biopsy) represent a possible expansion to the donor pool but are often discarded due to historical association…