ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Characterizing the Landscape and Impact of Infections Following Kidney Transplantation

    K. R. Jackson, J. Motter, R. Avery, W. Werbel, A. Massie, J. Garonzik-Wang, D. Segev

    Johns Hopkins University, Baltimore, MD

    *Purpose: Infections remain a major threat to successful kidney transplantation (KT), although there is limited data on the spectrum and clinical consequences of a post-KT…
  • 2020 American Transplant Congress

    Thymic B Cells: A Means to Control Regulatory Tolerance

    C. LeGuern1, S. Germana1, N. Feeney1, Z. Wang2, N. Tanimine1, C. Huang3, C. Rickert1, J. Markmann1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, 2University of Colorado Denver, Aurora, CO, 3Surgery, University of Colorado Denver, Aurora, CO

    *Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
  • 2020 American Transplant Congress

    Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates

    C. Blanton1, J. Reyes1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. vanAmersfoort2, J. Torrealba3, Y. Yankol1, A. D’Alessandro1, L. Fernandez1

    1University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UTSouthwestern, Dallas, TX

    *Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
  • 2020 American Transplant Congress

    Comparative Study between ATG and Grafalon as Induction Agent in Renal Transplant Recipient

    L. K. Das, P. Paudyal, S. Shrestha, B. Shahi, A. Pandey, R. Verma, P. Chandra Shrestha

    Kidney and Liver Transplant, Shahid Dharmabhakta National Transplant Center, Kathmandu, Nepal

    *Purpose: Renal transplantation (Rtx) remains the most effective treatment for of end-stage renal disease (ESRD). The development of induction therapy has significantly reduced the incidence…
  • 2020 American Transplant Congress

    Single-Cell RNA Sequencing Reveals Gene Expression Profiling of Ischemia Reperfusion Injury

    L. Wang, S. He, J. Xu, Z. Guo, X. He

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

    *Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation is an important factor that leads to graft dysfunction and even recipient death. This study aims to explore…
  • 2020 American Transplant Congress

    Health Professional Level Barriers to Living Donor Kidney Transplantation: A Mixed Methods Study

    R. Iskander1, M. Cantarovich1, N. Dendukuri1, M. Fortin2, S. Sandal1

    1McGill University, Montreal, QC, Canada, 2University of Montreal, Montreal, QC, Canada

    *Purpose: Despite the benefits of living donor kidney transplantation (LDKT), rates have stagnated. Efforts to increase LDKT have focused on patient level barriers. Health professionals…
  • 2020 American Transplant Congress

    Outcomes of High KDPI Kidneys in Selected Recipients at a Large Center

    J. Pagan, L. Preczewski, M. Muldoon, L. Mendez, A. Harshman, E. Shipman, G. Guerra

    Miami Transplant Institute, Miami, FL

    *Purpose: Kidneys from donors with high KDPI’s are frequently discarded due to concerns about short- and long-term outcomes. Despite the decreased graft survival of these…
  • 2020 American Transplant Congress

    Significance of Pathology in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results of the Paramour “Pediatric Renal AMR Outcomes” Study

    I. Ashoor1, A. Jain2, R. Garro3, M. Kallash4, S. Soloman5, K. Twombley6

    1LSUHSC and Children's Hospital New Orleans, New Orleans, LA, 2Children's Hospital of Michigan, Detroit, MI, 3Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, 4Nationwide Children's Hospital, Columbus, OH, 5Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, 6Medical University of South Carolina, Charleston, SC

    *Purpose: Little is known about how pathology findings on biopsy correlate with outcomes in pediatric kidney transplant patients with antibody mediated rejection (AMR). We aimed…
  • 2020 American Transplant Congress

    Pharmacokinetic Evaluation of a De Novo Envarsus XR® (tacrolimus Extended Release) Dosing Strategy in Kidney Transplant Recipients

    J. Schulte1, C. Kane1, K. Cunningham1, C. D'Agostino1, M. Kapugi1, A. Novak1, A. Shetty2, J. Leventhal2, J. Friedewald2

    1Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Division of Transplantation, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Envarsus XR® is a once-daily tablet formulation of tacrolimus recently approved for the prophylaxis of organ rejection in de novo kidney transplant recipients (KTx).…
  • 2020 American Transplant Congress

    Sleeve Gastrectomy Compared with Gastric Bypass for Morbidly Obese Liver Transplant Candidates: A Decision Analysis

    R. A. Choudhury1, D. Yoeli1, G. Hoeltzel2, H. B. Moore1, H. Yaffe1, K. R. Dumon3, N. N. Williams3, P. L. Abt4, K. D. Conzen1, J. J. Pomposelli1, E. A. Pomfret1, T. L. Nydam1

    1Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, 2Thomas Jefferson University Hospital, Philadelphia, PA, 3Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, 4Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA

    *Purpose: The use of bariatric surgery has increased for morbidly obese liver transplant candidates for whom placement on the waitlist is often restricted until they…
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