Am J Transplant, Volume 20, Suppl 3 Archives - Page 181 of 223 - ATC Abstracts

2020 American Transplant Congress
The Use of Scribes in Transplant Practice to Achieve Quality Outcomes and Foster Program Development
M. Debroy, K. Chavin
University Hospitals, Cleveland, OH
*Purpose: Transplantation is the most regulated surgical specialty in the US today. Transplant Centers (TC) are an increasingly pivotal component contributing to the fiscal viability…
2020 American Transplant Congress
Managing the Road to Kidney Transplantation in the Elderly
R. S. Munjal, K. Kalra, A. Cherukuri, D. Jorgensen, S. Verma, P. Sood, R. Mehta, C. Puttarajappa, S. Hariharan, C. Wu
Nephrology, UPMC, Pittsburgh, PA
*Purpose: We hypothesize that careful patient selection and waitlist management minimizes the impact of advanced recipient age on kidney transplant outcomes.*Methods: A total of 3,521…
2020 American Transplant Congress
Determinants of Kidney Transplant Candidates’ Willingness to Accept Deceased Donor Organ Intervention Research: A Conjoint Analysis
E. Gordon¹, P. Reese², J. Lee¹, L. Krishnamurthi¹, R. Veatch³, R. Knight⁴, P. T. Conway⁴, S. Dunn⁵, P. Abt²
¹Northwestern University, Chicago, IL, ²University of Pennsylvania, Philadelphia, PA, ³Georgetown University, Washington, DC, ⁴American Association of Kidney Diseases, Tampa, FL, ⁵Organ Alliance, Denver, CO
*Purpose: Deceased donor organ intervention research (“intervention research”) aims to increase organ quality and quantity for transplantation by protecting against organ injury and enhancing functionality.…
2020 American Transplant Congress
Desensitization Combining Costimulation Blockade with Proteasome Inhibition in Highly Sensitized Transplant Candidates
S. Restaino¹, D. Jennings², G. Serban³, E. Vasilescu³, G. Sayer¹, N. Uriel¹, K. Takeda⁴, Y. Naka⁴, M. Farr¹, M. V. Habal¹
¹Cardiology, Columbia University Irving Medical Center, New York, NY, ²School of Nursing, Columbia University Irving Medical Center, New York, NY, ³Pathology&Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁴Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibodies to human leukocyte antigens (HLA) pose a significant barrier to transplantation. Strategies to reduce allosensitization have modest efficacy and may result in antibody…
2020 American Transplant Congress
The Study of Continuous Renal Replacement Therapy Performing in Pre-Retrieval Management of Marginal Criteria Donor Lung: A Retrospective Control Study
J. Huang¹, X. Zheng², Z. Wang¹, M. Huang², J. Chen¹
¹Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China, ²General ICU, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
*Purpose: Ex vivo lung perfusion (EVLP) has successfully been applied to the management of marginal donor lungs, while the high cost and equipment lacking restrict…
2020 American Transplant Congress
Cognitive Impairment is Highly Prevalent in Lung Transplant Candidates
A. O'Boye, K. Leitner, M. Kelly, J. Wright, L. Pesce, M. Sala, R. Tomic
Northwestern Medicine, Chicago, IL
*Purpose: Lung transplantation is a lifesaving therapy in patients with advanced lung disease. Lung transplant recipients must have the ability to manage complex medical regimens…
2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…
2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
E. Cervantes-Alvarez¹, F. Tejeda-Dominguez², M. Lizardo-Thiebaud², E. Alatorre-Arenas³, O. Méndez-Guerrero¹, S. Yarza-Regalado¹, D. Kershenobich¹, A. Torre¹, M. Vilatobá⁴, C. A. Huang⁵, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, ³University of the Americas Puebla, School of Medicine, Puebla, Mexico, ⁴Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Surgery, University of Colorado Anschutz Medical Campus, Denver, CO
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…