Am J Transplant, Volume 20, Suppl 3 Archives - Page 168 of 223 - ATC Abstracts

2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
B. Kim¹, E. Kim², J. Kim², H. Choi³, H. Lee², J. Lee⁴, M. Kim⁴, Y. Kim⁴, K. Huh⁴
¹Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
2020 American Transplant Congress
Antibiotic Pretreatment Alleviates Liver Transplant Damage by Modulating the Composition of Commensal Microbiota
K. J. Dery, S. Kageyama, H. Hirao, K. Kadono, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The human intestinal microbiome contains more than 100 trillion commensal microorganisms, exceeding the number of cells in the human body by 10-fold. Although recent…
2020 American Transplant Congress
Two Novel Methods to Establish Rat Kidney Transplantation Model
M. Zheng, Z. Gui, Z. Wang, J. Wei, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Rat kidney transplantation model is a standard animal model for the anti-rejection research of kidney transplantation. However, the current methods of the model require…
2020 American Transplant Congress
Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway
Q. Yuan¹, S. Hong¹, E. Szuter¹, Y. Zhao¹, E. Acheampong¹, I. Rosales¹, M. Kronenberg², P. Russell¹, J. Madsen¹, R. Colvin¹, A. Alessandrini¹
¹Massachusetts General Hospital, Boston, MA, ²La Jolla Institute for Allergy & Immunology, La Jolla, CA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2020 American Transplant Congress
Follow Up of Imlifidase (IdeS) Desensitized Kidney Transplant Recipients
S. C. Jordan¹, R. A. Montgomery², T. Lundgren³, C. Legendre⁴, N. Desai⁵, G. Eckerwall⁶, L. Laxmyr⁶, H. Olsson⁶, A. Runström⁶, Å. Schiött⁶, K. Sjöholm⁶, E. Sonesson⁶, L. Winstedt⁶, T. Lorant⁷, C. Kjellman⁶
¹Cedars Sinai Medical Center, Los Angeles, CA, ²NYU Langone Health Transplant Institute, New York, NY, ³Karolinska University Hospital, Stockholm, Sweden, ⁴Hospital Necker & Paris Descartes University, Paris, France, ⁵Johns Hopkins University, Baltimore, MD, ⁶Hansa Biopharma AB, Lund, Sweden, ⁷Uppsala University, Uppsala, Sweden
*Purpose: 46 highly sensitized patients received kidney transplants after desensitization with imlifidase (currently under investigation) across four Phase 2 clinical trials, and 6-month safety and…
2020 American Transplant Congress
Basiliximab vs Antithymocyte Globulin Induction with Early Steroid Withdrawal in Kidney Transplant Recipients: Early Rejection Outcomes
A. Szczepanik¹, C. Burrelli¹, A. Bixby¹, K. Yadav², K. Chavin²
¹Pharmacy, University Hospital Cleveland Medical Center, Cleveland, OH, ²Surgery, University Hospital Cleveland Medical Center, Cleveland, OH
*Purpose: Steroid withdrawal within the first month of kidney transplant (KT) remains controversial and has demonstrated a higher risk of acute rejection. The impact of…
2020 American Transplant Congress
The New UK National Kidney Allocation Scheme with Maximized ‘D4/R4’ Kidney Transplants: Appropriate Donor to Recipient Matching or System Overstretch?
R. Pearson, E. Murray, P. Thompson, P. Mark, M. Clancy, J. Asher
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: The UK national deceased donor kidney matching scheme changed in September 2019, aiming to better match graft and patient survival. Donors and recipients are…
2020 American Transplant Congress
Is Dual Allocation Successful at Higher Remuzzi Scores? Outcomes of Dual Kidney Transplants at Remuzzi Scores of 8 or Greater
V. Fleetwood¹, C. Kensinger², C. Papageorge¹, D. Aufhauser¹, G. Leverson³, B. Welch¹, D. Foley¹, P. Pasha¹
¹Department of Transplantation, University of Wisconsin, Madison, WI, ²Department of Transplantation, Piedmont Transplant Center, Atlanta, GA, ³Department of Statistics, University of Wisconsin, Madison, WI
*Purpose: The Remuzzi score (RS) is a histologic assessment of donor kidneys based on degree of glomerulosclerosis, arterial narrowing, interstitial fibrosis, and tubular atrophy. The…
2020 American Transplant Congress
Identification of Eplet Mismatches Associated with De Novo Donor Specific HLA Antibody in a Pediatric Kidney Transplant Cohort
O. Charnaya, J. Jones, P. Chiang, M. C. Philogene, J. Garonzik-Wang
Johns Hopkins University, Baltimore, MD
*Purpose: While optimizing immunological matching will decrease the risk of de novo donor specific HLA antibody (dnDSA) formation and improve long-term graft function in pediatric…
2020 American Transplant Congress
Calcineurin Inhibitor Withdrawal is the Significant Risk Factor for De Novo DSA Production in Living Donor Kidney Transplantation
T. Hiramitsu¹, T. Tomosugi¹, K. Futamura¹, M. Okada¹, N. Goto¹, S. Narumi¹, K. Uchida², Y. Watarai¹
¹Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan, ²Masuko Memorial Hospital, Nagoya Aichi, Japan
*Purpose: For the long graft survival in the kidney transplantation, chronic antibody mediated rejection (CAMR) due to the de novo donor specific antibody (dnDSA) is…