Am J Transplant, Volume 20, Suppl 3 Archives - Page 168 of 223 - ATC Abstracts

2020 American Transplant Congress
Hematopoietic Cell Kinase Promotes Kidney Fibrosis Through Autophagy Pathway
C. Wei, L. Mou, K. Banu, M. Menon, W. Zhang, C. He, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In our previous studies, we identified hematopoietic cell kinase (HCK) as a key driver of renal fibrosis through TGFβ/Smad3 pathway. Here in this study,…
2020 American Transplant Congress
Early Steroid Withdrawal in HIV+ Kidney Transplant Recipients is Associated with Increased Acute Rejection by 1 Year
W. A. Werbel¹, S. Bae², S. Yu³, F. Al-Ammary⁴, C. M. Durand¹, D. L. Segev³
¹Infectious Diseases, Johns Hopkins University, Baltimore, MD, ²Epidemiology, Johns Hopkins University, Baltimore, MD, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Nephrology, Johns Hopkins University, Baltimore, MD
*Purpose: Kidney transplantation among HIV+ recipients (HIV+ KT) is increasing, with excellent outcomes. Acute rejection (AR), however, is 2-3-fold more common than in HIV- KT.…
2020 American Transplant Congress
Recurrent Lupus Post Kidney Transplantation- The Histological and Clinical Characteristics
A. Bentall¹, W. Jiqiu², A. Kattah¹, M. L. Gonzalez Suarez³, F. G. Cosio¹, M. Mai⁴, H. Khamash⁵, M. D. Stegall⁶, H. Amer¹, L. D. Cornell⁷, F. Fervenza¹, M. P. Alexander⁷
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²National Clinical Research Center of Kidney Diseases, Nanjing University, Nanjing, China, ³Department of Nephrology, University of Mississippi Medical Center, Jackson, MS, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Jackonville, FL, ⁵Division of Nephrology and Hypertension, Mayo Clinic, Scottdale, AZ, ⁶Department of Transplant Surgery, Mayo Clinic, Rochester, MN, ⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Lupus nephritis (LN) progresses to ESRD in
2020 American Transplant Congress
Offspring to Parent Living Donor Liver Transplantation: An Analysis of the A2ALL Database
R. A. Choudhury¹, H. J. Braun², J. D. Grab², J. L. Dodge², H. B. Moore¹, D. Yoeli¹, J. J. Pomposelli¹, T. Nydam¹, N. L. Ascher², E. A. Pomfret¹, J. P. Roberts²
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Department of Surgery- Division of Transplantation Surgery, University of California, San Francisco, San Francisco, CA
*Purpose: Recently, there have been concerns regarding inferior graft survival following offspring to parent kidney transplantation due to issues related to alloimmunity during pregnancy. It…
2020 American Transplant Congress
Reduced Dose Valganciclovir is Effective for CMV Prevention without Excess Breakthrough or Resistance in Kidney Transplantation
M. Luu¹, P. Klem¹, B. Crowther¹, M. Abidi², M. Miller¹, K. Schoeppler¹, S. Davis²
¹Pharmacy, University of Colorado Hospital, Aurora, CO, ²Medicine, University of Colorado, Aurora, CO
*Purpose: Reduced dose valganciclovir (VGC) (450 mg daily) may be a useful alternative to full dose VGC for cytomegalovirus (CMV) prophylaxis due to drug cost…
2020 American Transplant Congress
Calculating the Lung Allocation Score Error for ECMO Patients
N. Dussault¹, J. Katsis², E. Garrity¹, M. M. Churpek³, W. F. Parker¹
¹University of Chicago, Chicago, IL, ²Vanderbilt University, Nashville, TN, ³University of Wisconsin, Madision, WI
*Purpose: The use of extracorporeal membranous oxygenation (ECMO) as a bridge to lung transplantation has increased dramatically. However, the Lung Allocation Score (LAS) does not…
2020 American Transplant Congress
Preformed Donor Specific Antibody and Mfi-Dependent Effects in Simultaneous Liver-Kidney Transplantation
V. Fleetwood, C. Papageorge, D. Aufhauser, G. Leverson, B. Welch, L. Hidalgo, D. Foley, Y. Yankol, A. D'Alessandro, D. Al-Adra, R. Redfield, J. Mezrich
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: Preformed donor specific antibody to HLA Class II (pDSA) is suggested to be an independent risk factor for mortality in simultaneous liver and kidney…
2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
R. A. Naqvi¹, W. Zhang¹, A. Isidan¹, C. Evans-Molina², J. A. Fridell¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery, Indiana University, Indianapolis, IN, ²Diabetes Research Center, Indiana University, Indianapolis, IN
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
2020 American Transplant Congress
Initial North American Experience in Renal Transplantation from Medical Assistance in Dying Donors
M. A. Levine, S. Sami, A. Sener, P. Luke
Surgery, London Health Sciences Centre, London, ON, Canada
*Purpose: In 2016, Canadian federal legislation was passed creating a regulatory framework for medical assistance in dying (MAiD) for individuals who are suffering from a…
2020 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Mathew¹, J. Galvin², L. Gallon¹, D. Belshe¹, K. Ravindra³, M. Horwitz³, J. Miller¹, S. Ildstad⁴
¹Northwestern, Chicago, IL, ²UIC, Chicago, IL, ³Duke, Durham, NC, ⁴U Louisville, Louisville, KY
*Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…