ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction

    P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan

    Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY

    *Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
  • 2020 American Transplant Congress

    Allograft Repopulating Recipient B Cells after Human Intestinal Transplantation and Their Association with Donor Specific Antibody Secretion and Rejection

    E. Waffarn1, J. Fu1, K. Frangaj1, W. Meng2, A. M. Rosenfeld2, M. Li3, K. Rodgers1, R. Vasilescu3, E. T. Luning Prak2, A. Griesemer1, T. Kato4, M. Martinez5, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Pathology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY, 5Department of Pediatrics, Columbia University, New York, NY

    *Purpose: Alloantibodies produced by recipient B cells are associated with rejection after intestinal transplantation (ITx) and negatively impact patient and graft survival. However, the dynamics…
  • 2020 American Transplant Congress

    UNOS Hard to Place Kidneys: Are We Working Too Hard?

    S. Chaudhry, K. L. King, S. A. Husain, D. Cohen, L. Ratner, S. Mohan

    Columbia University, New York, NY

    *Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…
  • 2020 American Transplant Congress

    Optimal Timing of Renal Transplantation in Simultaneous Heart-Kidney Transplant: A Retrospective Analysis of the UNOS/OPTN Database

    A. S. Karim, G. E. Leverson, J. W. Smith, D. P. Foley

    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI

    *Purpose: In patients receiving a simultaneous heart-kidney transplant (SHKT) the optimal timing of performing the kidney transplant remains controversial. In the immediate approach (iHKT), the…
  • 2020 American Transplant Congress

    2019 Refined Criteria for Cirrhotic Cardiomyopathy Predict Post Liver Transplant Cardiac Events

    M. J. Izzy1, A. Soldatova2, X. Sun2, M. Angirekula3, K. Mara4, G. Lin2, K. Watt3

    1Gastroenterology and Hepatology, Vanderbilt University Medical Center, Nashville, TN, 2Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 3Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 4Health Sciences Research, Mayo Clinic, Rochester, MN

    *Purpose: Cirrhotic cardiomyopathy (CCM) encompasses systolic ± diastolic dysfunction (DD) in patients with end stage liver disease in the absence of known cardiac disease. The…
  • 2020 American Transplant Congress

    Antibiotic Stewardship and Inpatient C. Difficile Testing in Solid Organ Transplant Recipients, the Value of Multi-Level Checks and Balances

    M. Kueht, R. Britt, R. Ferren, M. Mujtaba, R. Ramirez, R. Kulkarni, A. Lea, J. Fair, D. Reynoso

    University of Texas Medical Branch, Galveston, TX

    *Purpose: Diarrhea in the solid organ transplant recipient is a commonly encountered problem and is often multifactorial in etiology. Due to the combination of peri-operative…
  • 2020 American Transplant Congress

    The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction

    A. Hata1, Y. Guo1, D. Li1, Z. Mei1, A. Manafi1, A. Banerjee1, B. Mahgoub1, T. H. Barker2, A. S. Krupnick1

    1Surgery, University of Virginia, Charlottesville, VA, 2Biomedical Engineering, University of Virginia, Charlottesville, VA

    *Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
  • 2020 American Transplant Congress

    Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion

    M. R. Connolly1, L. Burdorf1, S. Pratts1, B. Cerel1, Z. Abady1, W. Quin2, Y. Kan2, J. Layer2, M. Youd2, W. Westlin2, L. Yang2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2eGenesis, Cambridge, MA

    *Purpose: Physiologic behavior of porcine lungs with multiple xeno-targeted genetic modifications, Pig 2.0, have not previously been evaluated.*Methods: Eight pairs of lungs from Pig 2.0…
  • 2020 American Transplant Congress

    Belatacept Conversion: Are Patients BENEFIT-ing

    R. Crew, S. Mohan, S. S. Patel

    Columbia University Irving Medical Center, New York, NY

    *Purpose: Belatacept is increasingly used in renal transplant recipients experiencing adverse effects from calcineurin inhibitors(CNI) despite limited medium- and long- term data on safety and…
  • 2020 American Transplant Congress

    Gender Disparity in Living Donor Kidney Transplants

    A. Gruessner, S. Saggi, J. Renz, M. Markell, M. Salifu, R. Gruessner

    SUNY Downstate Medical Center, Brooklyn, NY

    *Purpose: Over the last decades, the number of kidney transplants has increased. However, more male than female patients receive a transplant. While the male/female ratio…
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