Am J Transplant, Volume 20, Suppl 3 Archives - Page 167 of 223 - ATC Abstracts

2020 American Transplant Congress
Membrane Expression of CD163 and CD206 by Blood Monocytes is Upregulated in Kidney Allograft Recipients
I. Striz, L. Curnova, V. Svachova, M. Fialova, M. Novotny, O. Viklicky
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Blood monocytes differentiating into tissue macrophages or dendritic cells are involved in multiple immune responses including reactions to the transplanted allograft. Peripheral monocytes can…
2020 American Transplant Congress
Two Pilot Studies Exploring the Diagnostic and Predictive Potential of Serum LAG3 and FGL1 in Kidney Transplant Recipients
Y. Li¹, L. Yan¹, Y. Li¹, C. Yang¹, Z. Wan¹, Y. An¹, Y. Bai¹, L. Wang¹, Y. Shi²
¹Department of Laboratory Medicine, West China Hospital, Chengdu, China, ²Department of Nephrology, West China Hospital, Chengdu, China
*Purpose: Lymphocyte activation gene 3 (LAG3), an immune checkpoint, plays an important role in the negative regulation of immune response and the induction of immune…
2020 American Transplant Congress
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
R. G. Bardallo¹, R. G. Teixeira-Silva², A. Panisello-Rosello³, E. Folch-Puy³, J. Rosello Catafau⁴, T. Carbonell⁵
¹Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain, ²Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, CSIC, Barcelona, Spain, ³Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, ⁴Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain, ⁵Cell Biology, Physiollogy and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain
*Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…
2020 American Transplant Congress
The Liver Regenerative Effect of Substance P after Major Hepatectomy in Rat Models
H. Ahn¹, Y. Kim¹, O. Kwon²
¹Surgery, Kyung Hee University, Seoul, Korea, Republic of, ²Surgery, Hanyang University, Seoul, Korea, Republic of
*Purpose: The hepatic damages are inevitable under liver surgery. Therefore, post-hepatectomy liver failure remains one of the most dangerous and life-threatening complications of hepatectomy. The…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level
I. Adam, B. Motyka, K. Tao, L. West
Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…
2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
W. Piao¹, Y. Xiong¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar³, L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³Surgery, U of Minnesota, Minneapolis, MN, ⁴Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…
2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, S. Kageyama¹, K. Nakamura¹, H. Hirao¹, H. Kojima¹, T. Ito¹, K. J. Dery¹, X. Li², R. W. Busuttil¹, F. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
S. Cai¹, S. Wang², W. Zhang², A. Chandraker¹, C. Yang², T. Zhu²
¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
2020 American Transplant Congress
A Video Education Intervention to Improve Kidney Transplant Knowledge and Willingness to Complete Transplant Evaluation in Dialysis Patients
D. A. DuBay¹, T. A. Morinelli¹, Z. Sutton¹, M. Chastain¹, T. Thompkins Tindal¹, Z. Su², E. Weeda³, P. Mauldin⁴, M. Casey¹, J. Bian², D. Taber¹, P. K. Baliga¹
¹Surgery, Division of Transplant Surgery, Medical University of South Carolina`, Charleston, SC, ²General Internal Medicine, Medical University of South Carolina`, Charleston, SC, ³Clinical Pharmacy-Outcomes Sciences, Medical University of South Carolina`, Charleston, SC, ⁴General Internal Medicine, Medical University of South Carolina, Charleston, SC
*Purpose: The Centers for Medicare and Medicaid Services has set a goal of 30% (currently 18.5%) of dialysis patients to be on a transplant (Tx)…