Am J Transplant, Volume 20, Suppl 3 Archives - Page 167 of 223 - ATC Abstracts

2020 American Transplant Congress
Utilization of High Terminal Creatinine Kidney Donors for Simultaneous Kidney and Pancreas Transplantation
A. Montal, J. Torabi, N. Muhdi, J. Melvin, Y. Miura, M. Ajaimy, L. Lirano, Y. Azzi, C. Pynadath, E. Akalin, S. Greenstein, J. P. Rocca, J. A. Graham
Montefiore Medical Center, Bronx, NY
*Purpose: The use of kidneys with high terminal creatinine has been demonstrated in renal transplantation with excellent outcomes. Here we explore the use of high…
2020 American Transplant Congress
Novel Biomarkers for Post-Transplant Recurrent IgA Nephropathy
Y. Caliskan¹, B. Dirim², E. Aksoy², R. Ouseph¹, Y. Ozluk³, H. Randall⁴, F. Savran Oguz⁵, A. Turkmen², M. S. Sever², K. Lentine¹
¹Division of Nephrology, Saint Louis University, Saint Louis, MO, ²Division of Nephrology, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Pathology, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Center for Abdominal Transplantation, Saint Louis University, Saint Louis, MO, ⁵Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul, Turkey
*Purpose: The aim of this study is to evaluate serum levels of galactose-deficient IgA1 (Gd-IgA1), advanced oxidation protein products (AOPP) and 4 tag single-nucleotide variants…
2020 American Transplant Congress
Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
2020 American Transplant Congress
Treg Stability Depends on Lymphotoxin Beta Receptor-Driven Migration
V. Saxena, W. Piao, L. Li, Y. Xiong, C. Palusckievicz, T. Simon, M. Shirkey, R. Abdi, J. S. Bromberg
University of Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) suppressor function for allograft survival requires maintenance of transcription factor Foxp3 and sequential migration from tissues to lymph nodes (LN).…
2020 American Transplant Congress
Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model
S. Lee¹, J. Lee², H. Park², Y. Kim², J. Noh³, J. Jung³, S. Lee³, H. Shin³, H. Yoon⁴, D. Lee³, S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, ⁴Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of
*Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
2020 American Transplant Congress
Natural Antibodies and Left Ventricular Assist Device Complications
S. B. See¹, D. Onat², E. Hittesdorf³, F. McDougan⁴, M. Yuzefpolskaya², V. K. Topkara², Y. Naka⁵, H. Takayama⁵, K. Takeda⁵, G. Milligan⁶, D. Wencker⁶, S. Hall⁶, M. Askar⁶, P. Kimball⁴, G. Wagener³, P. C. Colombo², E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, ²Department of Medicine, Columbia University Irving Medical Center, New York, NY, ³Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, ⁴Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA, ⁵Department of Surgery, Columbia University Irving Medical Center, New York, NY, ⁶Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX
*Purpose: Left ventricular assist device (LVAD) implantation is followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE)…
2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
H. Cho¹, J. Lee², B. Kwon³, S. Park⁴, H. Park⁴, K. Yoo², K. Park², J. Kim³, S. Kang³
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁴Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
H. Liu, Y. Chen, F. Qiu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
2020 American Transplant Congress
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
P. M. Patel¹, B. A. Gonzalez Nolasco¹, J. A. Morrissette¹, A. Prunevieille¹, K. J. Ahrens¹, J. M. O¹, D. C. Becerra¹, G. Benichou¹, J. C. Madsen²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Cardiac allograft tolerance in non-human primates (NHPs) has been achieved by our group via hematopoietic mixed chimerism consisting of an allogeneic bone marrow (BM)…
2020 American Transplant Congress
Lymphycyte Subset Test as a Determinant of Cytomegalovirus Prophylaxis in Renal Transplant Recipients
M. Kim, Y. Park, S. Mok, K. Jun, S. Kim, J. Kim, S. Yun, I. Moon, S. Park
Surgery, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: Cytomegalovirus (CMV) infection is an important complication after kidney transplantation (KT). Anti-thymocyte globulin (ATG) increases a risk of CMV infection and the American society…