Am J Transplant, Volume 20, Suppl 3 Archives - Page 155 of 223 - ATC Abstracts

2020 American Transplant Congress
Automated Electronic Donor Referrals Have Increased Donation
J. Piano
Transplant Connect, Santa Monica, CA
*Purpose: It is broadly understood and supported by previous studies that disruptive inefficiencies exist in the hospital to Organ Procurement Organization (OPO) donor referral process,…
2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
A. K. Singh¹, C. E. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor Inc, Blacksburg, VA
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…
2020 American Transplant Congress
Successful Long-Term TMA- and Rejection- Free Survival of a Kidney Xenograft with Triple Xenoantigen Knockout Plus Insertion of Multiple Human Transgenes
D. H. Ma¹, H. Sasaki¹, T. Hirose¹, I. Rosales¹, A. Dehnadi¹, R. Colvin¹, J. F. Markmann¹, W. Win², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², T. Kawai¹
¹Surgery, MGH, Boston, MA, ²eGenesis Inc., Cambridge, MA
*Purpose: Recent advances in genome engineering technology allow for the generation of porcine organ donors with multiplex gene edits. Here we evaluated survival of kidneys…
2020 American Transplant Congress
Improving Access to Transplantation and Outcomes for African American Patients
D. Bekbolsynov, O. Ekwenna, B. Mierzejewska, J. Borucka, S. A. Khuder, M. Rees, R. Green, S. Stepkowski
University of Toledo, Toledo, OH
*Purpose: Black or African American patients are clearly disadvantaged in comparison to Caucasian patients both in terms of the access to kidney transplantation and post-transplant…
2020 American Transplant Congress
Urinary Exosomal Hemopexin, a Validated Diagnostic Marker for Rejection in Kidney Transplant Recipients
J. Lee¹, J. Kim², G. Lee², S. Jeon², H. Noh², J. Lim², H. Jung², J. Choi², J. Cho², S. Park², Y. Kim², C. Kim²
¹Internal Medicine, Daegu Fatima Hospital, Daegu, Korea, Republic of, ²Internal Medicine, Kyungpook National University, Daegu, Korea, Republic of
*Purpose: Urinary exosomal hemopexin was identified as a potential diagnostic candidate for kidney allograft rejection in our previous proteomic study. We validated hemopexin as a…
2020 American Transplant Congress
In Silico Deconvolution of Whole Blood RNA-Seq Data from Iscalimab Phase IIa Study in Renal Transplant Reveals Insights Into Mechanism of Action and Superiority of Iscalimab Compared to Tacrolimus
J. S. Rush
Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland
*Purpose: A recent Phase 2 clinical study indicated that iscalimab, a pathway blocking, non-depleting anti-CD40 antibody, showed non-inferiority on a composite clinical endpoint, and improved…
2020 American Transplant Congress
Prognostic Impact of Peritumoral Neutrophil Infiltration on Hepatocellular Carcinoma Recurrence Following Liver Transplantation
M. Najjar¹, K. Halazun², M. Mondal¹, A. Srivastava¹, M. Moore¹, E. Rizk¹, R. Gartrell¹, H. Remotti¹, L. Fazlollahi¹, E. Verna¹, A. Griesemer¹, A. Mathur¹, B. Samstein², J. Emond¹, Y. Saenger¹
¹Columbia University Irving Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: Peritumoral neutrophil (PMN) infiltration has been associated with poor clinical outcomes in various tumors; however, its role in hepatocellular carcinoma (HCC) remains understudied. Moreover,…
2020 American Transplant Congress
Role of Circulating Exosomes in the Induction of Immune Responses Resulting in Cardiac Allograft Rejection in miR155 Knockout Animals
S. Bansal, Y. Itabashi, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Our goal is to define the mechanism by which circulating exosomes with cardiac self-antigens (SAgs), Myosin, Vimentin, and angiotensin Receptor 1 Protein (AGTR1) leads…
2020 American Transplant Congress
Platelets Stimulate Liver Regeneration in a 30% Partial Liver Transplantation Model in Rat
K. Takahashi, C. Liang, N. Ohkohchi, T. Oda
University of Tsukuba, Tsukuba, Japan
*Purpose: Liver transplantation (LT) is one of the most definitive treatments for patients with end-stage liver disease and acute liver failure, and it has been…
2020 American Transplant Congress
Induction of Transplant Tolerance by Modulating the Metabolic Stress Pathways
X. Xiao, L. Zhang, Y. Ying, Y. Wang, P. Arnold, Z. Zhang, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: T cell activation and effector differentiation precede graft rejection, and this process is associated with robust metabolic burst to meet the energy demand of…