Am J Transplant, Volume 20, Suppl 3 Archives - Page 132 of 223 - ATC Abstracts

2020 American Transplant Congress
Irf8-Relevant Mechanism in B Cell Regulation In Vitro
Q. Fu¹, K. Deng², H. Yang¹, J. F. Markmann², S. Deng¹
¹Organ Transplantation Center, and School of Medicine, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…
2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita⁴, M. Niimi¹
¹Surgery, Teikyo University, Tokyo, Japan, ²Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Hepato- Biliary- Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁴Immunology, Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…
2020 American Transplant Congress
Flow Cytometric Characterization of Regulatory Cell Populations Expanded Ex Vivo from PBMCs of Kidney Transplant Recipients
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam¹, A. Chandraker¹
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
*Purpose: We have previously shown that it is possible to generate alloantigen-specific regulatory T cell lines and clones that prolong allograft survival upon infusion in…
2020 American Transplant Congress
Prevalence of Frailty and Cognitive Impairment at Time of Kidney Transplant Evaluation
J. Klein, A. Jurgensen, M. Gupta, N. Herrera, A. Gupta, D. Cibrik
Internal Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Frailty is highly prevalent in kidney disease, with prevalence estimates as high as 73% in patients at the time of dialysis initiation compared to…
2020 American Transplant Congress
Flagging of Transplant Centers Associated with Increased Waitlist Mortality among Liver Candidates
R. L. Grant, B. A. Shelton, P. A. MacLennan, R. D. Reed, R. M. Cannon, B. J. Orandi, D. E. Eckhoff, J. E. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Previous studies have demonstrated decreased transplant rates among poor performing transplant centers meeting Centers for Medicare & Medicaid Services (CMS) flagging criteria. However, no…
2020 American Transplant Congress
Additive Effect of Obesity to Hypertension in Living Donors and Their Impact on Glomerular Filtration Rate Compensation with 5 Year Follow-Up
S. Quadri¹, H. Ali², T. Fulop¹, A. Osman³, K. Soliman¹
¹Nephrology, Medical University of South Carolina, Charleston, SC, ²Renal Medicine, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, ³Nephrology, Cairo University, Cairo, Egypt
*Purpose: Current data suggest that hypertensive donors can be considered for donation; however, the additive adverse effect of obesity and the risk of failing Glomerular…
2020 American Transplant Congress
Evaluation of Infectious and Malignant Complications in Elderly Renal Transplant Recipients Receiving Alemtuzumab Compared to Basiliximab
K. Lang¹, J. Shulte¹, K. Cunningham¹, C. D'Agostino¹, M. Kapugi¹, C. Kane¹, A. Novak¹, J. Leventhal²
¹Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, ²Division of Transplant Surgery, Northwestern Memorial Hospital, Chicago, IL
*Purpose: The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx), especially for elderly recipients. For this population, there is limited data…
2020 American Transplant Congress
The Banff Classification of Antibody-Mediated Rejection in Kidney Allografts: Comparison of Predictive Performance for Allograft Failure in Previous and Current Editions
J. Callemeyn¹, H. Ameye¹, M. Coemans¹, A. Senev², E. Lerut³, B. Sprangers¹, D. Kuypers¹, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium
*Purpose: Since its introduction in 2001, the Banff classification for antibody-mediated rejection (ABMR) has undergone significant changes, mainly by inclusion of C4d-negative ABMR in 2013…
2020 American Transplant Congress
Transplant Surgery Continuing Professional Development Courses Increase Knowledge and Procedural Confidence
M. J. Hobeika¹, T. Menser², A. Kassam³, T. C. Rice⁴, T. S. Diwan³
¹Houston Methodist Hospital, Houston, TX, ²Houston Methodist Research Institute, Houston, TX, ³University of Cincinnati Medical Center, Cincinnati, OH, ⁴Washington University, St. Louis, MO
*Purpose: Continuing professional development (CPD) workshops are emerging to fill critical knowledge and skill gaps in both surgical trainees and practicing surgeons. The ASTS has…