Am J Transplant, Volume 20, Suppl 3 Archives - Page 127 of 223 - ATC Abstracts

2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Prospective, Randomized Study of Conversion from Calcineurin Inhibitor (CNI)- to Belatacept (BELA)-Based Maintenance Immunosuppression in Renal Transplant Recipients
K. Budde¹, R. Prashar², H. Haller³, M. Rial⁴, N. Kamar⁵, A. Agarwal⁶, J. de Fijter⁷, L. Rostaing⁸, S. Berger⁹, A. Djamali¹⁰, N. Leca¹¹, L. Allamassey¹², S. Gao¹², M. Polinsky¹², F. Vincenti¹³
¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Henry Ford Hospital, Detroit, MI, ³The Hannover Medical School, Hannover, Germany, ⁴Instituto de Nefrologia, Nephrology SA, Buenos Aires, Argentina, ⁵University of Toulouse, Toulouse, France, ⁶UVA Health, Charlottesville, VA, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Université Grenoble Alpes, Saint-Martin-d'Hères, France, ⁹University Medical Centre Groningen, Groningen, Netherlands, ¹⁰University of Wisconsin, Madison, WI, ¹¹UW Medical Center, Seattle, WA, ¹²Bristol-Myers Squibb, Princeton, NJ, ¹³University of California, San Francisco, San Francisco, CA
*Purpose: CNIs are associated with adverse systemic and nephrotoxic effects that negatively impact long-term patient and graft survival. In a phase 2 study, switching renal…
2020 American Transplant Congress
Parathyroidectomy Post Kidney Transplant: A Single Center Report of Short Term Outcomes
S. Ong, F. Saad, K. Wille, C. Kew
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Whether parathyroidectomy in ESRD patients should be performed before or after kidney transplant remains controversial. There is concern that post-transplant parathyroidectomy can adversely affect…
2020 American Transplant Congress
Transarterial Chemoembolization and Radio-Embolization are Similarly Efficacious in Achieving Successful Hepatocellular Carcinoma (HCC) Down-Staging: Results from the Multicenter Evaluation of Reduction in Tumor Size Before Liver Transplantation (MERITS-LT) Consortium
N. Mehta¹, J. Guy², C. Frenette³, P. Tabrizian⁴, M. Hoteit⁵, N. Parikh⁶, T. Ghaziani⁷, R. Dhanasekaran⁷, J. L. Dodge¹, M. L. Holzner⁴, S. Florman⁴, F. Yao¹
¹UCSF, SF, CA, ²CPMC, SF, CA, ³Scripps Hospital, La Jolla, CA, ⁴Mt Sinai, NY, NY, ⁵U. Pennsylvania, Philadelphia, PA, ⁶U. Michigan, Ann Arbor, MI, ⁷Stanford, Palo Alto, CA
*Purpose: United Network of Organ Sharing (UNOS) Region 5 has reported excellent liver transplantation (LT) outcomes after successful down-staging (DS) in HCC patients exceeding Milan…
2020 American Transplant Congress
The Economic Impact of National Standardization of Virtual Crossmatch Usage in Kidney Transplantation
J. E. Stanton¹, L. M. Rebellato², H. Pournik¹, J. E. Tuttle-Newhall¹, H. Jones¹, W. Irish¹, D. B. Leeser¹
¹Department of Surgery, East Carolina University, The Brody School of Medicine, Greenville, NC, ²Department of Pathology, East Carolina University, The Brody School of Medicine, Greenville, NC
*Purpose: The implementation of virtual crossmatching (VXM) into conventional protocols may reduce expenditures associated with organ allocation.*Methods: A single center retrospective analysis of the total…
2020 American Transplant Congress
Lost to Follow-Up in Kidney Transplant Recipients – A QI Project
M. R. D'Costa, H. S. Ohl, S. Iyengar, K. C. Kolbet, C. L. Williams, K. A. Larson, M. S. Ward, H. M. Shriver, W. K. Kremers, M. El Ters
Mayo Clinic, Rochester, MN
*Purpose: Our center actively follows kidney transplant recipients (KTRs) from across the USA and many other countries for the life of the allograft with recommended…
2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
S. Lan¹, B. Yang¹, J. Sabo-Vatasescu², M. Bourgault², A. Karakeussian-Rimbaud³, J. Turgeon³, S. Qi¹, N. Patey⁴, M. Dieudé⁵, M. Hébert¹
¹Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³CRCHUM, CDTRP, Montreal, QC, Canada, ⁴Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, ⁵CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
2020 American Transplant Congress
Extracellular Vesicles Mediate Endothelial to Mesenchymal Transition and Tubular Senescence in Renal Antibody- Mediated Rejection by Inducing Complement Activation
G. Castellano, R. Franzin, A. Stasi, C. Divella, G. Merlotti, M. Quaglia, F. Sallustio, G. Stallone, V. Cantaluppi, L. Gesualdo
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: EVs (Extracellular vesicles), circulating microparticles able to mediate cell-to cell communication, are emerging as pivotal in different kidney diseases. Renal Antibody-Mediated Rejection (AMR) is…
2020 American Transplant Congress
Trough Level Compliance in Immunosuppression is Important to Protect Renal Function after Liver Transplantation – An Additional Analysis from the Hephaistos Study
P. Schemmer¹, F. Braun¹, H. J. Schlitt¹, A. Pascher¹, C. G. Klein¹, U. Neumann¹, I. Kroeger², P. Wimmer², B. Nashan¹
¹Hephaistos, Study Group, Germany, ²Novartis Pharma GmbH, Nürnberg, Germany
*Purpose: Most immunosuppressive drugs are dosed according to trough levels (C0-levels). To achieve the optimal balance between efficacy and safety, it is important to avoid…
2020 American Transplant Congress
Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection
V. Cantaluppi¹, G. Merlotti¹, M. Quaglia¹, G. Rosso¹, N. Clemente¹, G. Cappellano¹, A. Chiocchetti¹, G. Castellano², U. Dianzani¹, G. Camussi³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, ³Department of Medical Sciences, University of Torino, Torino, Italy
*Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…