Am J Transplant, Volume 20, Suppl 3 Archives - Page 126 of 223 - ATC Abstracts

2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…
2020 American Transplant Congress
A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates
C. Maguire¹, P. Muluhngwi¹, E. Kransdorf², L. Gragert³, A. R. Tambur¹
¹Northwestern University, Chicago, IL, ²Cedars-Sinai Heart Institute, Beverly Hills, CA, ³Tulane University, New Orleans, LA
*Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
2020 American Transplant Congress
Perioperative Anticoagulation Decreases Graft Thrombosis in Pancreas Transplantation
N. M. Handy¹, L. Skoval¹, J. Wingate², C. Kuhr³, N. Cowan³, J. Brandenberger¹
¹Section of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, Seattle, WA, ²Department of Urology, Madigan Army Medical Center, Tacoma, WA, ³Section of Urology, Virginia Mason Medical Center, Seattle, WA
*Purpose: Pancreas transplant thrombosis is the most common cause of graft failure in the early postoperative period, occurring 5-20% of cases. Bleeding (which occurs ~30%…
2020 American Transplant Congress
Bacterial Infection in Compensated Cirrhosis Predicts Inpatient Mortality and Readmission with Decompensation
R. Rosenblatt¹, A. Jesudian¹, C. Lucero¹, A. Kaplan¹, R. S. Brown¹, V. Sundaram², B. Fortune¹
¹Weill Cornell Medicine, New York, NY, ²Cedars Sinai, Los Angeles, CA
*Purpose: Identify the impact of bacterial infection on inpatient mortality and new decompensation in hospitalized patients with compensated cirrhosis from a nationally representative database.*Methods: This…
2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
J. A. Reyes¹, C. Blanton¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. van Amersfoort², J. Torrealba³, Y. Yankol¹, A. D'Allessandro¹, L. Fernandez¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UT Soutwestern, Dallas, TX
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…
2020 American Transplant Congress
Ambient Air Pollution and Waitlist Mortality among Lung Transplant Candidates
Y. Feng¹, M. R. Jones², N. Chu¹, D. Segev¹, M. McAdams-DeMarco¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Department Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
*Purpose: Previous studies suggested that air pollution is associate with higher risk of respiratory diseases and accelerated decline in lung function among general population. However,…
2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…
2020 American Transplant Congress
Conversion to a Belatacept Based Immunosuppression Regimen in Renal Transplant Recipients
K. Paplaczyk, K. Cunningham, C. D'Agostino, D. Pinelli, J. Schulte, A. Shetty
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Belatacept, a co-stimulation blocker, is an alternative anti-rejection agent that may avoid nephrotoxic or intolerable adverse effects of calcineurin inhibitor (CNI) or mammalian target…
2020 American Transplant Congress
Discrepant Subtyping of Blood Type A2 Living Kidney Donors in Paired Kidney Exchange
L. Warnke¹, R. R. Redfield¹, K. M. Miller¹, M. Cooper², G. Roll³, C. Freise³, B. Lee³, V. Chipman³, A. Thomas⁴, D. Leeser⁵, M. Ronin⁶, G. Hil⁶, A. D. Waterman⁷, D. Mandelbrot¹
¹Transplant, UW Health, Madison, WI, ²Transplant, Medstar Georgetown, Washington, DC, ³Transplant, UCSF, San Fransisco, CA, ⁴Surgery, Johns Hopkins University, Baltimore, MD, ⁵Transplant, ECU, Greenville, NC, ⁶NKR, Babylon, NY, ⁷Nephrology, UCLA; Terasaki Research Institute, Los Angeles, CA
*Purpose: Utilizing non-A1 donors for O or B recipients with low anti-A titers presents an opportunity to expand living donor kidney transplantation. Since February 2018,…
2020 American Transplant Congress
Potential Benefits of Y-90 Radiation Microspheres for Bridging Liver Candidates with Hepatocellular Carcinoma to Liver Transplant
S. Pelletier¹, J. Durden², S. Shan², P. Vargas³, N. Goldaracena¹
¹University of Virginia Health System, Charlottesville, VA, ²School of Medicine, University of Virginia Health System, Charlottesville, VA, ³Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: In October 2015, the UNOS policy for hepatocellular carcinoma (HCC) exception scores was changed to modify the maximum exception value and prolong the time…