Am J Transplant, Volume 20, Suppl 3 Archives - Page 118 of 223 - ATC Abstracts

2020 American Transplant Congress
Impact of Infectious Disease Intervention on Vaccine Compliance in Pediatric Heart Transplant Patients
S. R. Lauhon¹, G. Stendahl², P. Simpson³, S. J. Kindel², A. R. Punnoose², A. R. Huppler²
¹Medical College of Wisconsin, Wauwatosa, WI, ²Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI, ³Division of Quantitative Health Sciences, Medical College of Wisconsin, Wauwatosa, WI
*Purpose: This study assesses the impact of including an Infectious Disease (ID) component in the pre-transplant evaluation on patients’ compliance with the CDC recommended vaccination…
2020 American Transplant Congress
Cytomegalovirus Infection and Outcomes in Pancreas Transplant Recipients in the Prophylaxis Era
M. Jorgenson¹, N. Marka², G. Leverson², J. Smith², J. Odorico²
¹UW Health, Madison, WI, ²UWMF, Madison, WI
*Purpose: Evaluate epidemiology and outcomes of cytomegalovirus infection (CMV) in pancreas transplant recipients (PTR) in the current era of valganciclovir (VGC) prophylaxis (PPX)*Methods: Adult PTRs…
2020 American Transplant Congress
Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs
K. Petitpas¹, B. Cerel¹, Z. Abady¹, L. Burdorf¹, D. L. Ayares², D. M. Magnani³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Revivicor, Blacksburg, VA, ³MassBiologics of UMMS, Boston, MA
*Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
2020 American Transplant Congress
HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies
J. Lauronen¹, T. Jaatinen¹, J. Holgersson², C. Naper³, J. Peräsaari¹
¹Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, ²Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, ³Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway
*Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
2020 American Transplant Congress
Clinical Relevance of Immunoglobulin M Deposition in Peritubular Capillaries in ABO-Incompatible Kidney Transplantation
D. Toki¹, M. Okumi², K. Unagami², Y. Kakuta², H. Ishida², K. Yamashita¹, H. Tachibana¹, A. Hayashida¹, T. Horiuchi¹, Y. Ishiyama¹, K. Honda³, T. Kondo¹, K. Tanabe²
¹Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan, ²Urology, Tokyo Women's Medical University, Tokyo, Japan, ³Anatomy, Showa University, Tokyo, Japan
*Purpose: Immunoglobulin M (IgM) deposition in peritubular capillaries (PTCs) is rarely identified in renal allograft biopsies of ABO-compatible kidney transplantation. In ABO-incompatible kidney transplantation (ABOI-KTx)…
2020 American Transplant Congress
Single Center Experience in Using Donor-Derived Cell-Free DNA in Kidney Transplant
P. Homkrailas¹, S. Lee², B. Kandagedon¹, G. Danovitch¹, S. Bunnapradist¹
¹Medicine, Division of Nephrology, Kidney and Pancreas Transplant Programs, UCLA, Los Angeles, CA, ²Department of Pharmacy, UCLA, Los Angeles, CA
*Purpose: While the gold standard for diagnosing allograft rejection in kidney transplant recipients (KTX) continues to be histopathologic evaluation, it has been well recognized that…
2020 American Transplant Congress
Microarray and RNA-Seq Analysis of Rejection in Formalin-Fixed Paraffin-Embedded (FFPE) Biopsies: Comparing FFPE to Conventionally Stabilized (RNAlater Solution) Biopsies
P. Halloran¹, K. Famulski¹, J. Reeve¹, J. Huang², N. Alexandrov²
¹University of Alberta, Edmonton, AB, Canada, ²R&D Transplant Diagnostics Division, Thermo Fisher Scientific, Los Angeles, CA
*Purpose: Molecular understanding of organ transplant biopsies requires genome-wide measurements and molecular classifiers. To assess potential of performing molecular diagnostics on formalin-fixed paraffin-embedded (FFPE) biopsies,…
2020 American Transplant Congress
Influence of the Gut Microbiota on Acute Rejection of Vascular Allografts
J. C. Choy, K. Rey, W. Enns, T. Van Rossum, F. S. Brinkman
Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
*Purpose: The gut microbiota influences immune responses in many ways but its involvement in transplant rejection is poorly understood. We have examined how changes in…
2020 American Transplant Congress
Prognostic Value of Dd-cfDNA Assay in Acute Renal Rejection Therapy: A Prospective Cohort Study
L. Guo, R. Wang, J. Lv, J. Shen, J. Wu, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Donor-derived cell free DNA (dd-cfDNA) is a promising biomarker for monitoring allograft status. However, whether it is capable of reflecting real time anti-rejection treatment…
2020 American Transplant Congress
A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse
R. Plenter¹, S. Jain², J. J. Pomposelli¹, T. Nydam¹, A. Jani²
¹Pulmonary Division, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…