Am J Transplant, Volume 20, Suppl 3 Archives - Page 115 of 223 - ATC Abstracts

2020 American Transplant Congress
Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation
B. Lamarthée¹, A. Marchal¹, S. Charbonnier¹, T. Blein¹, K. Vogt², M. Titeux¹, N. Pallet³, M. Delville¹, E. Six¹, D. Anglicheau⁴, C. Legendre⁴, B. Sawitzki², J. Taupin⁵, M. Cavazzana¹, I. André¹, J. Zuber¹
¹Inserm U1163, Institut Imagine, Paris, France, ²Department of Immunology, Charité University Hospital, Berlin, Germany, ³Inserm U1147, Centre Universitaire des Saints Pères, Paris, France, ⁴Service de Transplantation Rénale Adulte, Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Paris, France, ⁵Inserm U1160, Centre Hayem, Paris, France
*Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…
2020 American Transplant Congress
Re-Establishing Abstinence after Alcohol Relapse after Early Transplant (LT) for Alcoholic Hepatitis (AH) Provides Survival Advantage
J. Rice¹, B. Lee², G. Therapondos³, G. Im⁴, A. Lazar², M. Lucey¹, E. Weinberg⁵, H. Han⁶, H. Maddur⁷, M. Ghobrial⁸, C. Hsu⁹, O. Fix¹⁰, S. Eswaran¹¹, K. Shetty¹², N. Jakhete¹², D. Victor⁸, D. Foley¹, N. Mehta², M. Rinella⁷, T. Schiano⁴, C. Mobley⁸, N. Terrault⁶
¹U of WI SMPH, Madison, WI, ²UCSF, San Francisco, CA, ³Oschner, New Orleans, LA, ⁴Mt Sinai, New York, NY, ⁵U Penn, Philadelphia, PA, ⁶USC, Los Angeles, CA, ⁷NW Univ, Chicago, IL, ⁸Houston Mdt, Houston, TX, ⁹GTown U, Washington, DC, ¹⁰Swed Med, Seattle, WA, ¹¹Rush Med C, Chicago, IL, ¹²U of MD, Baltimore, MD
*Purpose: Among the ACCELERATE-AH cohort: (i) Identify factors associated with re-established abstinence in patients with alcohol relapse after LT for alcoholic hepatitis (AH); (ii) Determine…
2020 American Transplant Congress
Outcomes of Kidney Retransplantation after Post-Transplant Lymphoproliferative Disorders: An Analysis of the UNOS/OPTN Database (1998 to 2019)
W. Cheungpasitporn¹, C. Thongprayoon², C. C. Jadlowiec³, W. J. Chon⁴, L. S. Cummings⁴, S. R. Katari⁴, N. Leeaphorn⁴
¹Nephrology, University of Mississippi Medical Center, Jackson, MS, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Transplant Surgery, Mayo Clinic, Phoenix, AZ, ⁴Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO
*Purpose: Post-transplant lymphoproliferative disease (PTLD) is a serious, potentially fatal complication after kidney transplantation. Existing literature on outcomes of kidney retransplantation in patients with prior…
2020 American Transplant Congress
Risk Factors for Early Graft Loss and Mortality in Pancreas Transplant Recipients: A Multivariate Analysis of U.S. Transplants
S. M. Riad¹, A. Adamusiak², S. Jackson³, E. B. Finger², R. Kandaswamy²
¹Medicine, University of Minnesota, Minneapolis, MN, ²Surgery, University of Minnesota, Minneapolis, MN, ³Complex Care Analytics, Fairview Health Services, Minneapolis, MN
*Purpose: There is limited data on trends of early graft loss within 90 days (EGL). Pancreas donor risk index (PDRI) is a scale of pancreas…
2020 American Transplant Congress
Apoptotic Exosome-Like Vesicles are Associated with Alloimmune Vascular Injury in Kidney Transplant Recipients
M. Dieude¹, E. Boilard², I. Allaeys², A. Deneault-Marchand¹, J. Turgeon¹, E. Dore², S. Lariviere-Beaudoin¹, A. Karakeussian-Rimbaud¹, S. Collette³, L. Senecal³, M. Hebert¹, H. Cardinal¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ²Centre de Recherche du Centre Hospitalier de l'Université de Québec, Quebec, QC, Canada, ³Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
*Purpose: There is no non-invasive biomarker of alloimmune vascular injury. We have previously characterized exosome-like vesicles enriched in active proteasome and LG3 (ApoExo) that are…
2020 American Transplant Congress
Opioid-Free Pain Control? Surgical Opioid Avoidance Protocol (SOAP) Following Kidney Transplant
J. Benken¹, M. Campara¹, E. Votta Velis², I. Tzvetanov³, E. Benedetti³
¹Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, ²Anesthesiology, University of Illinois at Chicago, Chicago, IL, ³Surgery, University of Illinois at Chicago, Chicago, IL
*Purpose: The opioid epidemic within the United States has devastated patients and their families in addition to triggering a national public health crisis. Unnecessary prescribing…
2020 American Transplant Congress
Mental Health of Unspecified Anonymous Living Kidney Donors after Donation
W. Zuidema¹, S. Ismail², J. Wetering van de¹, L. Raalten van², W. Weimar¹, E. Massey¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ²Psychiatry, Erasmus MC, Rotterdam, Netherlands
*Purpose: Aim: Anonymous living kidney donors donates to an unknown stranger. These donors undergo psychosocial assessment to minimize likelihood of psychological harm from donation. The…
2020 American Transplant Congress
Traveling For Transplant: A Comparison of Singly Listed, Multiply Listed, and Non-Citizen Non-Resident Liver Transplant Candidates
H. J. Braun¹, D. Amara¹, A. Shui¹, C. Huang¹, P. G. Stock¹, R. Hirose¹, F. L. Delmonico², N. L. Ascher¹
¹University of California, San Francisco, San Francisco, CA, ²Harvard Medical School, Boston, MA
*Purpose: Multiply listed (ML) and non-citizen non-resident (NCNR) patients comprise approximately 8% of the liver transplant (LT) waitlist (WL) and approximately 4% of LT recipients.…
2020 American Transplant Congress
Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury
M. Ni¹, D. Jin², T. Lu², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, J. Zhang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
*Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…
2020 American Transplant Congress
Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity
J. Y. Choi¹, S. K. Eskandari¹, S. Cai¹, J. Assaker¹, I. Sulkaj¹, H. Allos¹, J. Alhaddad¹, P. Chu¹, H. Kim², H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Immunology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…