2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…2020 American Transplant Congress
Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation
Surgery, University of Wisconsin, Madison, WI
*Purpose: The development and maintenance of peripheral tolerance is required for long term success of solid organ transplantation without immuno-suppressive drugs. Using a novel, post-transplant,…2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
1University of Virginia, Charlottesville, VA, 2University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…2020 American Transplant Congress
Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients
*Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…2020 American Transplant Congress
UK Residents Transplanted Overseas: A Summary of UK Data from 2000-2016
*Purpose: Organ shortage has prompted UK residents to source organs overseas. Little is known about the circumstances in which these transplants take place, but stories…2020 American Transplant Congress
Direct Acting Anti-Viral Prophylaxis to Prevent Virus Transmission from Hepatitis C Viremic Donors to Hepatitis C Negative Kideney Transplant Recipients
Virginia Commonwealth University, Richmond, VA
*Purpose: Previous trials in kidney transplantation (KT) have described a 12-week course of direct-acting anti-viral drugs (DAA) to treat HCV transmission from infected donors to…2020 American Transplant Congress
Survival Benefit of Accepting Kidneys from Older Donation after Cardiac Death Donors
*Purpose: Kidneys from older donation after cardiac death (DCD) donors are less likely to be transplanted due to concerns about inferior post-transplant survival. But candidates…2020 American Transplant Congress
Deceased Donors in Kidney Paired Donation
*Purpose: A kidney paired donation pool (KPDP) consists of transplant candidates and their incompatible living donors along with nondirected living donors (NDDs). In a match…2020 American Transplant Congress
Widespread Deregulation of Metabolic Genes in Steatotic Livers Pre- And Post-Transplantation
*Purpose: The escalating obesity crisis is a double-edged sword for the field of liver transplantation; higher rates of fatty liver disease increase both the demand…2020 American Transplant Congress
Comparative Analysis of Kidney Transplant-Specific versus Hospital-Wide Antibiograms
Medical University of South Carolina, Charleston, SC
*Purpose: Solid organ transplant (SOT) recipients are more likely to develop antimicrobial-resistant infections versus the general population, but few transplant centers have developed SOT-specific antibiograms…
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