Am J Transplant, Volume 20, Suppl 3 Archives - Page 112 of 223 - ATC Abstracts

2020 American Transplant Congress
PD-1 Signals Murine and Human Treg for Enhanced Migration
W. Piao¹, Y. Xiong¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar³, L. Riella⁴, J. Bromberg⁵
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³Surgery, U of Minnesota, Minneapolis, MN, ⁴Harvard U, Boston, MA, ⁵Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Programmed death-1 (PD-1) attenuates immune responses. Engagement of PD-1 by its ligands PD-L1 or PD-L2 regulates T cell development, proliferation, cytokine production, and apoptosis.…
2020 American Transplant Congress
Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human
K. Kadono¹, S. Kageyama¹, K. Nakamura¹, H. Hirao¹, H. Kojima¹, T. Ito¹, K. J. Dery¹, X. Li², R. W. Busuttil¹, F. Kaldas¹, J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
S. Cai¹, S. Wang², W. Zhang², A. Chandraker¹, C. Yang², T. Zhu²
¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
2020 American Transplant Congress
A Video Education Intervention to Improve Kidney Transplant Knowledge and Willingness to Complete Transplant Evaluation in Dialysis Patients
D. A. DuBay¹, T. A. Morinelli¹, Z. Sutton¹, M. Chastain¹, T. Thompkins Tindal¹, Z. Su², E. Weeda³, P. Mauldin⁴, M. Casey¹, J. Bian², D. Taber¹, P. K. Baliga¹
¹Surgery, Division of Transplant Surgery, Medical University of South Carolina`, Charleston, SC, ²General Internal Medicine, Medical University of South Carolina`, Charleston, SC, ³Clinical Pharmacy-Outcomes Sciences, Medical University of South Carolina`, Charleston, SC, ⁴General Internal Medicine, Medical University of South Carolina, Charleston, SC
*Purpose: The Centers for Medicare and Medicaid Services has set a goal of 30% (currently 18.5%) of dialysis patients to be on a transplant (Tx)…
2020 American Transplant Congress
The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation
P. Khairallah, J. Kamal, E. Vasilescu, I. Batal, G. Dube
Columbia University Medical Center, New York, NY
*Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…
2020 American Transplant Congress
Frailty Attenuates the Gender Gap in Waitlist Mortality in Liver Transplant Candidates: A Multi-Center Study with 1,240 Patients with Cirrhosis
J. C. Lai¹, D. R. Ganger², M. L. Volk³, J. L. Dodge¹, M. A. Dunn⁴, A. Duarte-Rojo⁵, M. R. Kappus⁶, R. S. Rahimi⁷, D. Ladner², B. Boyarsky⁸, M. McAdams-DeMarco⁸, D. L. Segev⁸, C. E. McCulloch¹, E. Verna⁹
¹UCSF, San Francisco, CA, ²NW, Chicago, IL, ³Loma Linda Univ, Loma Linda, CA, ⁴UPMC, Pittsburgh, CA, ⁵UPMC, Pittsburgh, PA, ⁶Duke, Durham, NC, ⁷Baylor, Dallas, TX, ⁸JHMI, Baltimore, MD, ⁹Columbia, New York, NY
*Purpose: Women LT candidates experience higher rates of waitlist mortality than men. Frailty is a critical determinant of mortality in patients with cirrhosis but it…
2020 American Transplant Congress
Single-Dose Anti-Thymocyte Globulin is Non-Inferior to Divided-Dose for Induction Therapy in Kidney and Pancreas Transplantation
A. I. Ingemi¹, O. F. Bangash¹, S. McCoy¹, L. Hulse², J. Colonna¹, H. Sadr¹, S. Sutton¹, M. Coleman¹, T. Wilson¹, T. R. McCune¹
¹Sentara Norfolk General Hospital, Norfolk, VA, ²Children's Hospital of the King's Daughters, Norfolk, VA
*Purpose: Emerging studies suggest that single-dose rabbit antithymocyte globulin (rATG) is not inferior to the divided-dose, however this dosing strategy has never been evaluated in…
2020 American Transplant Congress
Novel Treatment of Acute Antibody-Mediated Rejection in a Nonhuman Primate Model of Kidney Allotransplantation
R. Schmitz¹, Z. W. Fitch¹, A. Y. Choi¹, M. Manook¹, J. Yoon¹, J. D. Lambris², J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience acute antibody mediated rejection (AMR) with limited treatment options. We tested a novel treatment strategy for…
2020 American Transplant Congress
Quantifying Gender-Based Disparties in Liver Allocation: A Path Forward
B. A. Shelton¹, K. Olthoff², E. Pomfret³, K. A. Forde², D. Sawinski⁴, M. Gray¹, N. Ascher⁵, J. E. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Colorado School of Medicine, Denver, CO, ⁴University of Pennsylvania, Philadelphia, PA, ⁵University of California at San Francisco School of Medicine, San Francisco, CA
*Purpose: Differences in local organ supply and demand have introduced geographic inequities in the Model for End-stage Liver Disease (MELD) based liver allocation system prompting…
2020 American Transplant Congress
Outcomes Following Resection of Mixed Hepatocellular-Cholangiocarcinoma, Hepatocellular Carcinoma, and Intrahepatic Cholangiocarcinoma: A Matched Analysis
M. L. Holzner¹, F. Parvin-Nejad², K. Fei³, S. Florman¹, M. E. Schwartz¹, P. Tabrizian¹
¹Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Mixed hepatocellular-cholangiocarcinoma (HCC-CC) is a biphenotypic liver cancer thought to have unfavorable tumor biology and a poor prognosis. Surgical outcomes of HCC-CC remain unclear.…