Am J Transplant, Volume 19, Suppl 3 Archives - Page 99 of 214 - ATC Abstracts

2019 American Transplant Congress
Multi-omic Analysis Of Hepatic Ischemia/reperfusion Injury Identifies Novel Targets To Mitigate Hepatocellular Damage
S. Duarte¹, V. Boominathan², Z. Huo³, A. Kobayashi², U. Kim², Y. Lai², A. Coito¹, A. Zarrinpar²
¹Surgery, UCLA, Los Angeles, CA, ²Surgery, University of Florida, Gainesville, FL, ³Biostatistics, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major risk factor for acute rejection and early graft dysfunction in liver transplantation. The large and complex landscape…
2019 American Transplant Congress
The Efficacy of Spheroidal Hepatocytes for Hepatocyte Transplantation
K. Shibuya, M. Watanabe, Y. Ganchiku, R. Kanazawa, Y. Koshizuka, M. Zaitsu, R. Goto, A. Taketomi
Department of Gastroenterological Surgery Ⅰ Hokkaido University Graduate School, Sapporo, Japan
*Purpose: Hepatocyte transplantation (HCTx) is expected to expand its application as a next generation therapy alternative to liver transplantation. Following HCTx, the liver function improves…
2019 American Transplant Congress
Increase in Proinflammatory CD14++CD16+ Monocytes in Samples from Aspiration Cytology Compared with Peripheral Blood in Kidney Transplant Patients with Borderline Rejection
T. Vazquez-Sanchez¹, A. Caballero-Gonzalez², E. Sola¹, P. Ruiz-Esteban¹, E. Marques¹, J. Alonso-Titos¹, E. Palma¹, C. Jironda¹, M. Cabello¹, V. Lopez¹, P. Hidalgo¹, M. Leon¹, D. Hernandez¹
¹Nephrology, Hospital Regional Universitario de Málaga, Universidad de Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Immunology, Hospital Regional Universitario de Málaga, Universidad de Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain
*Purpose: Monocytes comprise a heterogeneous population divided according to the membrane expression level of their molecules. One of these populations is the CD14++CD16+, which presents…
2019 American Transplant Congress
Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys
A. Weissenbacher¹, H. Huang², A. Thorne³, L. M. Lo Faro³, J. Hunter³, R. Ploeg³, C. C. Coussios⁴, P. J. Friend³, B. Kessler⁵
¹Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria, ²Nuffield Department o Medicine, Target Discovery Institute, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Department o Medicine, Target Discovery Instituteiscovery Institute, University of Oxford, Oxford, United Kingdom
*Purpose: We have shown that 24h normothermic kidney perfusion (NKP) with urine recirculation (URC) is superior to non URC for maintaining homeostasis previously. However, the…
2019 American Transplant Congress
Urinary Biomarkers- CXCL9 and CXCL10 for Non-Invasive, Early Diagnosis of Rejection in Pediatric Renal Transplantation
R. P. George¹, B. Hanberry², I. Dave², B. Lee², R. Garro¹, C. McCracken², B. Warshaw¹
¹Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, ²Pediatrics, Emory University, Atlanta, GA
*Purpose: Renal transplantation is the treatment of choice for End Stage Renal Disease, but requires strict medication adherence and lifelong surveillance for rejection, infection and…
2019 American Transplant Congress
Multiple Non-HLA Antibodies Are Significantly Increased in Chronic Active Antibody Mediated Rejection
K. Sablik¹, E. Kamburova², D. Roelen³, H. Otten², M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Leiden, Leiden, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is characterized by continuous inflammation at the level of the microvascular endothelium. Although donor-specific anti-HLA antibodies play an important…
2019 American Transplant Congress
A2 To B Kidney Transplants Under Kidney Allocation System: A Prospective Study Of Anti A Titers And Correlation With Outcomes
H. Schaefer, I. Feurer, S. Rega, R. Forbes, D. Shaffer
Vanderbilt University, Nashville, TN
*Purpose: The UNOS KAS system incorporates A2 to B deceased donor kidney transplants (DDKTx) to improve access and reduce disparities in wait times for B…
2019 American Transplant Congress
Should First and Second Transplant Candidates Be Treated Equally?
S. Clark, M. Kadatz, J. Gill, J. S. Gill
Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: To inform future organ distribution policy.*Methods: We determined access to deceased donor transplantation, transplant survival, the duration of additional renal replacement therapy needed within…
2019 American Transplant Congress
Implementation of a De Novo Belatacept Protocol
D. Wojciechowski¹, M. Jacobs², K. Safa¹, H. Gilligan¹, H. Eliot¹, W. W. Williams, Jr¹
¹Massachusetts General Hospital, Boston, MA, ²Wake Forest, Winston-Salem, NC
*Purpose: The use of belatacept with basiliximab induction and maintenance MMF/prednisone when compared to cyclosporine is associated with superior long-term patient and graft survival but…
2019 American Transplant Congress
A Retrospective Observational Analysis of Tacrolimus Metabolism Rate: No Evidence for Impact on Renal Function
A. J. Hughes, J. E. Kimpton, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: A previous publication found that fast metabolisers of tacrolimus had inferior renal function compared to slow metabolisers in a Caucasian population (Thölking et al.,…