Am J Transplant, Volume 19, Suppl 3 Archives - Page 99 of 214 - ATC Abstracts

2019 American Transplant Congress
Early Tacrolimus Trough Concentration Variability Could Predict Rejection in Pediatric Liver Transplantation: A Single-Center and Retrospective Research
G. Gu, Q. Xia
Renji Hospital, Shanghai, China
*Purpose: With great development in immunosuppressive therapy, the long-term outcomes and survival time in patients who received solid organ transplantation have been improved remarkably. The…
2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
A. Gillooly¹, C. Moore¹, J. Perry¹, I. Bruggenwirth², M. Thijssen², X. Wang¹, X. E¹, P. Mandrekar¹, T. Kowalik¹, R. Porte², H. Leuvenink², R. Abdi³, A. Bozorgzadeh¹, P. N. Martins¹
¹University of Massachusetts Medical School, Worcester, MA, ²University of Groningen, Groningen, Netherlands, ³Brigham and Women's Hospital, Boston, MA
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…
2019 American Transplant Congress
Identification and Determinants of Cardiac Allograft Vasculopathy Trajectories after Heart Transplantation
G. Bonnet¹, G. Coutance¹, M. Racape¹, M. Raynaud¹, J. Van keer², M. Bories¹, S. Varnous³, P. Rouvier³, R. Guillemain⁴, L. Lecuyer⁴, P. Bruneval⁴, J. Duong-Van-Huyen¹, J. Taupin⁵, M. Naesens², C. Lefaucheur¹, X. Jouven¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²KU Leuven, Leuven, France, ³Pitie Salpetriere Hospital, Paris, France, ⁴Georges Pompidou Hospital, Paris, France, ⁵Saint Louis Hospital, Paris, France
*Purpose: CAV is a major contributor of heart transplant recipient’s mortality. However, little is known about CAV long-term evolution profiles and their determinants. Such information…
2019 American Transplant Congress
Eculizumab Deposition in Renal Transplants
D. WANG¹, S. H. Nasr¹, A. B. Farris², C. A. Schinstock³, M. P. Alexander¹, L. D. Cornell¹
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, ²Pathology & Laboratory Medicine, Emory University, Atlanta, GA, ³Division of Nephrology & Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN
*Purpose: Eculizumab is a recombinant humanized IgG monoclonal antibody that inhibits C5, thereby preventing the activation of C5a and formation of membrane attack complex C5b-C9.…
2019 American Transplant Congress
External Validation of the Living Kidney Donor Profile Index (LKDPI) in the Canadian Kidney Transplant Recipient Population
M. Shantier¹, Y. Li¹, M. Ashwin¹, O. Famure¹, S. K. Singh²
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Medicine, University of Toronto, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: The LKDPI is a risk index which incorporates clinical characteristics of living kidney donors and their recipients to predict the risk of total graft…
2019 American Transplant Congress
A Priori Identification of Hard-to-Place Livers
A. Wey¹, N. Hadley¹, J. Rosendale², R. Hunter², J. Prinz², K. Audette¹, N. Salkowski¹, D. Zaun¹, J. Snyder³
¹SRTR, Minneapolis, MN, ²OPTN, Richmond, VA, ³SRTR, Mineeapolis, MN
*Purpose: Identification of hard-to-place deceased donor livers is important due to its potential role in expedited placement. Determining hard-to-place must be based on data available…
2019 American Transplant Congress
The mIR17-92 Cluster Promotes Costimulation Resistant Effector Memory T Cell-Mediated Alloresponses
H. Xu¹, Q. Guo¹, M. Song¹, A. Miler¹, Q. Li², A. Kirk¹
¹Surgery, Duke University, Durham, NC, ²Immunology, Duke University, Durham, NC
*Purpose: CD57 expression has been shown to identify a subset of memory T cells that are resistant to CD28/B7 costimulation blockade (B7CoB). This study was…
2019 American Transplant Congress
A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine
A. G. L'Huillier, V. H. Ferreira, Y. Natori, T. Ku, C. Hirzel, M. Ierullo, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
2019 American Transplant Congress
Outcomes of Adult Lung Transplant Recipients of Donation after Circulatory Death Allografts in the US
W. S. Cherikh¹, J. Stehlik², A. Sadavarte¹, D. Van Raemdonck³
¹United Network for Organ Sharing, Richmond, VA, ²University of Utah School of Medicine, Salt Lake City, UT, ³University Hospitals Leuven, Leuven, Belgium
*Purpose: This analysis was performed to compare outcomes of adult lung (LU) transplant (TX) recipients of donation after circulatory death (DCD) and donation after brain…