Am J Transplant, Volume 19, Suppl 3 Archives - Page 97 of 214 - ATC Abstracts

2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, A. Bozovic¹, V. Kulasingam¹, P. Chen⁴, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹University Health Network, Toronto, ON, Canada, ²Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, ³Krembil Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
2019 American Transplant Congress
Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)
C. Divella¹, A. Stasi¹, R. Franzin¹, F. Sallustio², C. Curci¹, G. Merlotti³, M. Quaglia³, L. Gesualdo¹, V. Cantaluppi¹, G. Castellano¹
¹Emergency and Organ Transplantation, University of Bari, Bari, Italy, ²Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
*Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
2019 American Transplant Congress
Trends and Geographic Variation in the Recovery of Organs from Drug-Overdose Deaths with Donor Potential
V. Garcia, D. Stewart, J. Rosendale
Research, UNOS, Richmond, VA
*Purpose: The opioid crisis in the US and related increase in donors that died from drug-intoxication are well-documented. We set-out to estimate the proportion of…
2019 American Transplant Congress
First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant
J. Weiner¹, S. Moturi¹, C. Ashokkumar², K. Khan¹, S. Kaufman¹, R. Sindhi², C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²University of Pittsburgh, Pittsburgh, PA
*Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…
2019 American Transplant Congress
Vo_2peakSuperior to Current Established Measure of Post Kidney Transplant Survival Score (EPTS Score)
H. Chakkera¹, R. Butterfield¹, M. Buras¹, B. Kaplan²
¹Mayo Clinic Hospital, Phoenix, AZ, ²Baylor Scott and White, Dallas, TX
*Purpose: The Scientific Registry of Transplant Recipients (SRTR) utilizes the calculated estimated posttransplant survival (EPTS) score as the measure of post kidney transplant survival to…
2019 American Transplant Congress
Early Impact of the New United Network for Organ Sharing Simultaneous Liver-Kidney Transplantation Allocation Policy: Improved Standardization but Similar Utilization
G. Cullaro¹, E. C. Verna², J. C. Lai¹
¹UCSF, San Francisco, CA, ²Columbia University, New York, NY
*Purpose: In an effort to standardize SLKT utilization, UNOS/OPTN implemented a new SLKT policy on August 10th, 2017. We aimed to characterize the early impact…
2019 American Transplant Congress
Halt-hcc At The Time Of Listing Is Superior To Other Allocation Metrics At Predicting Waitlist Dropout; An Srtr Analysis
J. C. McVey¹, K. Sasaki¹, D. J. Firl², C. M. Miller¹, K. Hashimoto¹, C. Quintini¹, F. N. Aucejo¹
¹Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, ²Department of General Surgery, Duke University, Durham, NC
*Purpose: A recently developed liver allocation metric, Hazard Associated with Liver Transplant for Hepatocellular Carcinoma (HALT-HCC), has been shown to predict post-transplantation survival and recurrence.…
2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Preservation Consistently Improves Extreme Marginal Graft Function Compared to Hypothermic Machine Perfusion
P. Urbanellis¹, M. Hamar¹, I. Linares¹, D. Kollmann¹, S. Ganesh¹, F. Oquendo¹, M. Sharma¹, R. John¹, A. Ghanekar¹, I. Mucsi¹, D. Bagli², A. Konvalinka¹, L. Robinson³, M. Selzner¹
¹Multi-Organ Transplantation Program, University Health Network, Toronto, ON, Canada, ²Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP promoted improved marginal graft function compared to…
2019 American Transplant Congress
Women Who Undergo Liver Transplant Have Increased Health Care Utilization in the Peri-Transplant Period Compared with Men
J. B. Rubin, G. Cullaro, J. Ge, J. C. Lai
Department of Medicine, Division of Gastroenterology & Hepatology, Univeristy of California-San Francisco, San Francisco, CA
*Purpose: We have previously shown that women on the liver transplant (LT) waitlist are at greater risk of hospitalization compared with men, but whether this…