2019 American Transplant Congress
The Increasing Financial Challenge of Liver Transplantation
*Purpose: Despite innovations in clinical care, liver transplant (LT) remains highly resource intensive due to medical complexity and organ quality. National allocation systems prioritize access…2019 American Transplant Congress
p40 Homodimer Indirectly Induce Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High-Risk Allografts via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4…2019 American Transplant Congress
The End of Non-Directed Living Kidney Donation: The National Kidney Registry’s Family Voucher Program
*Purpose: The continued growth of the National Kidney Registry’s (NKR) Voucher program has extended Kidney Paired Donation (KPD) to include chronological incompatibility which is facilitating…2019 American Transplant Congress
Improving Medication Adherence and Outcomes in Adult Kidney Transplant Patients Using SystemCHANGETM: Results of the Medication Adherence Given Individual Change (MAGIC) Randomized Clinical Trial
*Purpose: Medication non-adherence is an obdurate problem associated with poor outcomes and staggering costs. Even with multi-faceted interventions, effect sizes reported in meta-analyses of medication…2019 American Transplant Congress
The Benefit of Kidney Transplantation over the Waitlist Depends on the Patient’s Comorbidities
*Purpose: This study aimed to determine the impact of different comorbidities to the survival benefit of Kidney Transplantation (KTx) compared to waitlisted (WL) patients in…2019 American Transplant Congress
Donation after Cardiac Simultaneous Liver-Kidney: An Updated Perspective
*Purpose: Historically, the outcomes from donation after cardiac death (DCD) donors have been shown to be inferior as compared to those of donation after brain…2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…2019 American Transplant Congress
Hepatitis C Positive Donor to Negative Recipient Kidney Transplantation: A Single Center Real World Experience
North Shore University Hospital, Manhasset, NY
*Purpose: Several small studies have shown that transplanting a hepatitis C virus (HCV) negative recipient with a HCV positive donor is feasible in a research…2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…2019 American Transplant Congress
Concentric Circles, One Year in: Concentrated Organ Discard and Waitlist Deaths in High Traffic Areas
1Emory, Atlanta, GA, 2Vanderbilt, Nashville, TN, 3Washington University St. Louis, St. Louis, MO
*Purpose: Lung transplantation was the first organ system to entirely dispense with Donor Service Areas (DSAs) and Regions in favor of 250 nautical mile (NM)…
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