ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Interstitial Fibrosis and Tubular Atrophy

    G. Gupta1, D. Kumar1, M. Raynaud2, A. Loupy2, J. Chang3, J. Reeve3, P. Sanghi1, I. Yakubu1, L. Kamal1, M. Levy1, C. Bhati1, P. Kimball1, A. King1, H. Massey1, P. Halloran3

    1Virginia Commonwealth University, Richmond, VA, 2Paris Transplant Group, Paris, France, 3Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Prior studies on the conversion of tacrolimus (Calcineurin Inhibitor; CNI) to belatacept have been limited in scope due to either the absence of, post-conversion…
  • 2019 American Transplant Congress

    More Advanced Heart Failure Prior To Transplant May Influence The Cytomegalovirus Specific T Cell Response In Cytomegalovirus Positive Recipients.

    U. López Cardoza, E. García, C. Díez, J. Roca, N. Sabé, N. Manito, I. Tatjer, A. Cequier, O. Bestard, J. González

    Bellvitge Universitary Hospital, L' Hospitalet de Llobregat, Spain

    *Purpose: Current assessment of risk of Cytomegalovirus (CMV) infection in CMV+ heart transplant (HT) recipients is poor. A diminished CMV-specific T cell response against 2…
  • 2019 American Transplant Congress

    Tocilizumab for Refractory Antibody-Mediated Rejection in Pediatric Kidney Transplantation

    A. Dokras, C. Butler, Q. Zhang, E. Reed, R. Ettenger, P. Weng, M. Pearl

    University of California, Los Angeles, Los Angeles, CA

    *Purpose: IL-6 blockade may play a role in reducing human leukocyte antigen donor specific antibodies (HLA DSA) production and stabilizing allograft function. We aimed to…
  • 2019 American Transplant Congress

    Gut Dysbiosis Predominates Post-Transplant Diarrhea in Kidney Transplant Recipients: A Validation Study

    L. Zhang, J. Lee, M. Magruder, E. Edusei, D. Dadhania, M. Lubetzky, S. Albakry, B. Botticelli, E. Pamer, M. Suthanthiran

    Weill Cornell Medicine, New York, NY

    *Purpose: Lower abundance of commensal bacterial taxa in the gut has been previously described in a recent study of kidney transplant recipients with post-transplant diarrhea…
  • 2019 American Transplant Congress

    Occult Liver Graft Fibrosis Prior to Transplantation Influences Clinical Outcomes

    H. Hirao, T. Ito, K. Kadono, S. Kageyama, K. Nakamura, K. J. Dery, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Liver transplantation (LT) has become a standard therapy for the management of end-stage liver disease, while early allograft dysfunction (EAD) remains a serious problem.…
  • 2019 American Transplant Congress

    A Clinical Pharmacogenetic Model to Predict the Efficacy of Sirolimus during the Early Administration in Renal Transplant Recipients

    Z. Wang, S. Fei, Z. Han, J. Tao, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: This study was to develop a clinical pharmacogenetic model to predict the efficacy of sirolimus during the early administration in renal transplant recipients. 70…
  • 2019 American Transplant Congress

    The Economic Burden of Graft Failure in the United States

    J. A. Sussell1, A. R. Silverstein1, P. Goutam1, D. Incerti1, R. Kee1, D. S. Batty, Jr.2, C. X. Chen2, J. Jansen1, B. L. Kasiske3

    1Precision Health Economics, Oakland, CA, 2Medeor Therapeutics, South San Francisco, CA, 3Hennepin County Medical Center, Minneapolis, MN

    *Purpose: Despite recent advances, graft failure imposes a substantial burden on kidney transplant recipients. This study is the first to quantify this burden in economic…
  • 2019 American Transplant Congress

    Urinary Injury Biomarkers in Deceased Donors and Acute Rejection Post Kidney Transplant

    P. Reese1, I. Hall2, S. Mohan3, H. Theissen-Philbrook4, Y. Jia4, M. Doshi5, J. Bromberg6, S. Mansour7, M. Harhay8, F. Weng9, E. Akalin10, C. Parikh4

    1UPENN, Philadelphia, PA, 2Univ of Utah, Salt Lake City, UT, 3Columbia, NY, NY, 4Johns Hopkins, Baltimore, MD, 5Univ of Michigan, Ann Arbor, MI, 6Univ of Maryland, Baltimore, MD, 7Yale, New Haven, CT, 8Drexel, Philadelphia, PA, 9St. Barnabas, Philadelphia, PA, 10Montefiore, NY, NY

    *Purpose: Acute kidney injury (AKI) is common among deceased kidney donors. We hypothesized that inflammation from kidney injury could lead to enhanced expression of HLA…
  • 2019 American Transplant Congress

    Earlier Transplant Education as CKD Progresses? CKD 3-5 Patients and Providers Weigh In

    A. D. Waterman1, O. N. Ranasinghe1, A. F. Lipsey2, C. S. Anderson1, A. Alem3, C. Bozzolo4, B. Dub3, S. L. Henry3, B. Mittman3

    1Division of Nephrology, UCLA School of Medicine, Los Angeles, CA, 2Terasaki Research Institute, Los Angeles, CA, 3Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, 4Insight Policy Research, Arlington, VA

    *Purpose: To increase preemptive and early transplant rates, transplant education must be delivered along the entire chronic kidney disease (CKD) spectrum. To understand patients’ education…
  • 2019 American Transplant Congress

    Evolution of HHV6- and CMV-Specific T Cell Functional Responses and Immune Cell Populations after Kidney Transplant

    A. Gil1, M. Co2, M. Calvo-Calle1, J. Cruz1, L. Stern1, L. Gibson2

    1Pathology, University of Massachusetts Medical School, Worcester, MA, 2Medicine, University of Massachusetts Medical School, Worcester, MA

    *Purpose: Human herpesvirus (HHV)-6 reactivation after solid organ or hematopoietic stem cell transplant has been associated with complications such as graft rejection and all-cause mortality.…
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