Am J Transplant, Volume 19, Suppl 3 Archives - Page 95 of 214 - ATC Abstracts

2019 American Transplant Congress
Identification and Determinants of Cardiac Allograft Vasculopathy Trajectories after Heart Transplantation
G. Bonnet¹, G. Coutance¹, M. Racape¹, M. Raynaud¹, J. Van keer², M. Bories¹, S. Varnous³, P. Rouvier³, R. Guillemain⁴, L. Lecuyer⁴, P. Bruneval⁴, J. Duong-Van-Huyen¹, J. Taupin⁵, M. Naesens², C. Lefaucheur¹, X. Jouven¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²KU Leuven, Leuven, France, ³Pitie Salpetriere Hospital, Paris, France, ⁴Georges Pompidou Hospital, Paris, France, ⁵Saint Louis Hospital, Paris, France
*Purpose: CAV is a major contributor of heart transplant recipient’s mortality. However, little is known about CAV long-term evolution profiles and their determinants. Such information…
2019 American Transplant Congress
Eculizumab Deposition in Renal Transplants
D. WANG¹, S. H. Nasr¹, A. B. Farris², C. A. Schinstock³, M. P. Alexander¹, L. D. Cornell¹
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, ²Pathology & Laboratory Medicine, Emory University, Atlanta, GA, ³Division of Nephrology & Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN
*Purpose: Eculizumab is a recombinant humanized IgG monoclonal antibody that inhibits C5, thereby preventing the activation of C5a and formation of membrane attack complex C5b-C9.…
2019 American Transplant Congress
External Validation of the Living Kidney Donor Profile Index (LKDPI) in the Canadian Kidney Transplant Recipient Population
M. Shantier¹, Y. Li¹, M. Ashwin¹, O. Famure¹, S. K. Singh²
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Medicine, University of Toronto, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: The LKDPI is a risk index which incorporates clinical characteristics of living kidney donors and their recipients to predict the risk of total graft…
2019 American Transplant Congress
A Priori Identification of Hard-to-Place Livers
A. Wey¹, N. Hadley¹, J. Rosendale², R. Hunter², J. Prinz², K. Audette¹, N. Salkowski¹, D. Zaun¹, J. Snyder³
¹SRTR, Minneapolis, MN, ²OPTN, Richmond, VA, ³SRTR, Mineeapolis, MN
*Purpose: Identification of hard-to-place deceased donor livers is important due to its potential role in expedited placement. Determining hard-to-place must be based on data available…
2019 American Transplant Congress
The mIR17-92 Cluster Promotes Costimulation Resistant Effector Memory T Cell-Mediated Alloresponses
H. Xu¹, Q. Guo¹, M. Song¹, A. Miler¹, Q. Li², A. Kirk¹
¹Surgery, Duke University, Durham, NC, ²Immunology, Duke University, Durham, NC
*Purpose: CD57 expression has been shown to identify a subset of memory T cells that are resistant to CD28/B7 costimulation blockade (B7CoB). This study was…
2019 American Transplant Congress
A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine
A. G. L'Huillier, V. H. Ferreira, Y. Natori, T. Ku, C. Hirzel, M. Ierullo, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
2019 American Transplant Congress
Outcomes of Adult Lung Transplant Recipients of Donation after Circulatory Death Allografts in the US
W. S. Cherikh¹, J. Stehlik², A. Sadavarte¹, D. Van Raemdonck³
¹United Network for Organ Sharing, Richmond, VA, ²University of Utah School of Medicine, Salt Lake City, UT, ³University Hospitals Leuven, Leuven, Belgium
*Purpose: This analysis was performed to compare outcomes of adult lung (LU) transplant (TX) recipients of donation after circulatory death (DCD) and donation after brain…
2019 American Transplant Congress
Donor Derived Cell Free DNA Initiates De-Novo Donor Specific Antibody (DSA) Responses
S. Jordan¹, D. Sawinski², S. Dholakia³
¹Cedars-Sinai, Los Angeles, CA, ²Hospital of the University of Pennsylvania, Philadelphia, PA, ³CareDx, Brisbane, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury, may contribute to sensitization of the recipients’ immune system. Antigenic presentation of donor-derived nucleic acids,…
2019 American Transplant Congress
Machine Perfusion Allows Use of High KDPI and Prolonged Cold Ischemia Time in Deceased Donors: A Single Center Effort to Decrease Discard Rates
M. Ortigosa-Goggins, J. Gaynor, A. Mattiazzi, J. Figueiro, G. Burke, G. Ciancio, G. Guerra
Miami Transplant Institute, University of Miami, Miami, FL
*Purpose: Discard rates of deceased donor kidney transplants(DDKT)rises as the kidney donor profile index(KDPI)increases,and approaches 60%for KDPI of >85%.Pulsatile machine perfusion(MP)allows use of kidneys with…
2019 American Transplant Congress
The Outcomes after an Infection in Older Liver Transplant Recipients is Comparable to Younger Adults
J. Garcia-Diaz¹, M. Kerkelis², T. Shah³, M. Tucker⁴, M. Gastanaduy⁵, J. Woo¹, M. Ponder¹, M. Malinis⁶, M. Malinis⁶
¹Infectious Diseases, Ochsner Medical Center, New Orleans, LA, ²University of Queensland/Ochsner Clinical School, New Orleans, LA, ³Internal Medicine, St. Joseph Hospital, Denver, CO, ⁴Internal Medicine, Yale School of Medicine, New Haven, CT, ⁵Center for Outcomes and Health Services Research, Ochsner Medical Center, New Orleans, LA, ⁶Infectious Diseases, Yale School of Medicine, New Haven, CT
*Purpose: Solid organ transplantation is being increasingly offered to older patients with concurrent chronic medical conditions such as cardiovascular, cerebrovascular, and renal disease. Risk of…