Am J Transplant, Volume 19, Suppl 3 Archives - Page 95 of 214 - ATC Abstracts

2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
L. Qiu¹, J. Wang¹, X. Yeap¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…
2019 American Transplant Congress
Alcohol Recidivism In Liver Transplant Recipients With Alcoholic Liver Disease: Does Six-months Abstinence Rule Still Holds True?
S. K. Satapathy¹, C. Thornburgh¹, J. Yu², J. Eason¹, S. Kedia², D. Maluf¹
¹UTHSC, Memphis, TN, ²University of Memphis, Memphis, TN
*Purpose: Liver transplant for alcoholic liver disease (ALD) continues to be a challenge for transplant centers, particularly related to the ethical dilemma of transplanting or…
2019 American Transplant Congress
Fifteen Year Outcomes in the Astellas Double Blind Randomized Controlled Trial (RCT) Comparing Early Corticosteroid Withdrawal (CSWD) and Long-Term Corticosteroid Therapy Continuation (CCS) in Kidney Transplantation
E. Woodle¹, S. Clark², D. Stewart³, M. First⁴, R. Alloway⁵, J. Gill⁶, .. Split Rock Group⁷
¹Transplant Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ²Providence Health Care, Vancouver, BC, Canada, ³UNOS, Richmond, VA, ⁴Transplant Genomics Inc. and Comprehensive Transplant Center, Northwestern University, Evanston, IL, ⁵University of Cincinnati College of Medicine, Cincinnati, OH, ⁶University of British Columbia, Vancouver, BC, Canada, ⁷Yale University, New Haven, CT
*Purpose: To evaluate long-term outcomes among participants in the original multi-center RCT initiated in 1999 (Woodle et al, Annals of Surgery, 2008), and to demonstrate…
2019 American Transplant Congress
The Degree of Glomerulosclerosis in Procurement Renal Biopsy and its Implications in Predicting Graft Outcomes in Marginal Donor Kidneys
W. Cheungpasitporn¹, W. Chon², E. Island², L. Cummings², J. Forster², N. Leeaphorn²
¹University of Mississippi Medical Center, Jackson, MS, ²Saint Luke's Health System, Kansas City, MO
*Purpose: Percentage of glomerulosclerosis (GS) is a major determinant for kidney discard. However, GS failed to consistently predict graft outcomes across studies in the literature.…
2019 American Transplant Congress
Contemporary US Prevalence and Outcomes of Pneumocystis jirovecii Pneumonia and Toxoplasmosis in Pediatric Solid Organ and Hematopoietic Cell Transplantation Recipients
M. I. Ardura¹, J. Stanek², B. Hanisch³, B. Hanisch⁴, K. Sprott⁵, H. Rangarajan⁶
¹Pediatrics, Infectious Diseases & Host Defense, Nationwide Children's Hospital & The Ohio State University, Columbus, OH, ²Pediatrics, Biostatistics, Nationwide Children's Hospital, Columbus, OH, ³Pediatrics, Infectious Diseases, Children's National Health System, Washington, DC, ⁴Pediatrics, Infectious Diseases, Children's National Health System & The George Washington University, Washington, DC, DC, ⁵Pediatrics, Pharmacy, Medical University of South Carolina, Charleston, SC, ⁶Pediatrics, Hematology/Oncology/HCT, Nationwide Children's Hospital & The Ohio State University, Columbus, OH
*Purpose: We sought to evaluate the contemporary prevalence and outcomes of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis among pediatric transplantation recipients in the US in…
2019 American Transplant Congress
Dendritic Cells Transduced with Autoimmune Regulator Exhibit Immature Properties and Prolong Heart Allograft Survival
Y. Zhang, Z. Zhu, M. Chen, S. Huang, C. Sun, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The expression of the Aire (Autoimmune regulator) gene was observed to inhibit the maturation and activation of dendritic cells (DCs) and induce transplantation tolerance.*Methods:…
2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
2019 American Transplant Congress
Diminishing Scientific Registry of Transplant Recipients Risk-Adjusted Mortality: Reaction to Flagging, Artifact of Modeling, or Both?
J. A. Gregg¹, K. L. Womer¹, A. Santos¹, S. J. Moore², K. A. Andreoni³
¹Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL, ²Shands Transplant Center, University of Florida, UF Health Shands, Gainesville, FL, ³Department of Surgery, University of Florida, Gainesville, FL
*Purpose: To examine longitudinal trends in SRTR risk-adjusted patient and graft survival rates.*Methods: Current, and archived versions of The Scientific Registry of Transplant Recipients (SRTR)…
2019 American Transplant Congress
Preliminary Results from a Multicenter National Trial of Antiviral-Facilitated Transplantation of Hepatitis C Hearts to Expand the Donor Pool
K. Martits-Chalangari, A. K. Doss, M. Clark, J. Felius, S. A. Hall, R. L. Gottlieb
Baylor University Medical Center, Dallas, TX
*Purpose: Solid organs from donors with evidence of active HCV viremia are historically underutilized particularly for HCV negative recipients. The development of easily tolerated, oral,…