ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    A Novel Genomic Approach for Acute Rejection across All Age Groups in Kidney Transplantation

    B. I. Shaw, D. K. Cheng, Q. Cheng, C. R. Acharya, A. D. Kirk, E. T. Chambers

    Pediatrics/Surgery, Duke University, Durham, NC

    *Purpose: Acute Rejection remains a significant complication in kidney transplantation that affects long-term outcomes. Using a large collection of gene expression data obtained from multiple…
  • 2019 American Transplant Congress

    Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection

    Z. Zhang1, Q. Liu1, T. Li1, G. S. Hussey2, M. Velayutham1, J. L. Dziki2, L. R. Mathews1, Y. C. Lee2, G. K. Dwyer1, H. Dai1, A. S. Roessing1, S. Shiva3, M. H. Oberbarnscheidt1, S. F. Badylak2, H. R. Turnquist1

    1Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2Department of Bioengineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 3Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Pittsburgh, PA

    *Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…
  • 2019 American Transplant Congress

    Renal Recovery and Prognostic Factors in Children Following Liver Transplantation

    R. Büscher, N. Gantenberg, A. Büscher, E. Lainka, P. Hoyer

    Department of Pediatrics II, University Hospital Essen, Essen, Germany

    *Purpose: Progression to chronic renal disease (CKD) is highly prevalent in adults following liver transplantation (LT) with a profound impact on patient survival, assuming that…
  • 2019 American Transplant Congress

    Successful Weaning Of Parenteral Nutrition After Serial Transverse Enteroplasty: The Largest Series Of Adult Short Gut Syndrome Patients

    M. Fujiki, S. Armanyous, K. Abu-Elmagd

    Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Serial Transverse Enteroplasty Procedure (STEP) is an effective procedure to restore nutritional autonomy, but with limited experience especially in adult patients. The aims of…
  • 2019 American Transplant Congress

    Deceased-Donor Acute Kidney Injury Associates with Less BK Viremia in Kidney Transplant Recipients

    I. E. Hall, P. P. Reese, S. G. Mansour, S. Mohan, M. D. Doshi, Y. Jia, H. R. Thiessen-Philbrook, E. Akalin, M. N. Harhay, T. Muthukumar, B. Schröppel, P. Singh, F. L. Weng, J. S. Bromberg, C. R. Parikh

    For the DDS Consortium, Baltimore, MD

    *Purpose: BK viremia (BKV) and polyomavirus nephropathy are kidney transplant complications that contribute to morbidity and graft loss, and prior studies suggest they may be…
  • 2019 American Transplant Congress

    Estimated Glomerular Filtration Rate at Donor Screening to Predict Measured Glomerular Filtration Rate after Living Kidney Donation

    J. van der Weijden, M. van Londen, M. Y. Said, S. J. Bakker, S. P. Berger, G. Navis, M. H. de Borst

    Nephrology, University Medical Center Groningen, Groningen, Netherlands

    *Purpose: Accurate post-donation renal function prediction is important to minimize the risk of future severe renal function impairment in living kidney donors. Recent studies focused…
  • 2019 American Transplant Congress

    Is Alemtuzumab Induction Safe In Septuagenarians Undergoing Deceased Donor Kidney Transplantation?

    D. Harriman, V. Gurram, C. Jay, J. Rogers, A. Farney, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, R. Stratta

    Wake Forest Baptist Medical Center, Winston-Salem, NC

    *Purpose: Alemtuzumab induction in septuagenarians is controversial but understudied.*Methods: Single center retrospective review of adult deceased donor kidney transplant (KT) recipients receiving single dose (30…
  • 2019 American Transplant Congress

    Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation

    J. Fu1, J. Zuber1, B. Shonts1, A. Obradovic1, K. Frangaj1, E. E. Waffarn1, S. Lau1, T. M. Savage1, S. Yang1, K. Rogers1, P. Satwani2, S. Ho1, Y. Shen3, A. Griesemer4, M. Martinez2, T. Kato4, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Systems Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…
  • 2019 American Transplant Congress

    Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity

    S. K. Eskandari1, M. B. Melo2, I. Sulkaj1, N. Li2, S. Cai1, H. Allos1, J. Y. Choi1, D. J. Irvine2, J. R. Azzi1

    1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 2David H. Koch Institute for Integrative Cancer Research, Cambridge, MA

    *Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
  • 2019 American Transplant Congress

    Development of a Pharmacy Collaborative Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic

    R. Chelewski1, K. Johnson1, A. Zuckerman2, J. DeClercq3, L. Choi3, M. Peter2, A. J. Langone4

    1Vanderbilt Specialty Pharmacy Services, Vanderbilt Univ Medical Ctr, Nashville, TN, 2Department of Pharmacy, Vanderbilt Univ Medical Ctr, Nashville, TN, 3Department of Biostatistics, Vanderbilt Univ Medical Ctr, Nashville, TN, 4Division of Nephrology, Vanderbilt Univ Medical Ctr, Nashville, TN

    *Purpose: This study describes the development of a Collaborative Pharmacy Practice Agreement (CPPA) between transplant pharmacists and physicians and assesses change in prescription volume and…
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