2019 American Transplant Congress
Opening the Doors of Hope: HIV-Positive Living Kidney Donation
Duke University Medical Center, Durham, NC
*Purpose: Living donation (LD) has been allowed under the HOPE Act since 2013, yet to date there have been no HIV+ LD organ transplants performed…2019 American Transplant Congress
To Each Their Own: Center-Level Variation in Tailoring Induction Immunosuppression to Kidney Transplant Recipients
Johns Hopkins University, Baltimore, MD
*Purpose: Ideally, induction immunosuppression should be selected in a personalized manner. However, there is little knowledge of what clinical factors are considered in this process…2019 American Transplant Congress
Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking
*Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…2019 American Transplant Congress
Results from the LIVE-C Free Trial
*Purpose: Ledipasvir/sofosbuvir (LDV/SOF) in combination with ribavirin (RBV) has shown excellent results post-liver transplant. However, due to the poor tolerability of RBV, it is commonly…2019 American Transplant Congress
Role of Procurement and Reperfusion Biopsy in Kidney Transplant in Evaluating and Predicting Outcomes of Deceased Donor Kidneys
*Purpose: Pathologic assessment of donor organs by use of procurement biopsies (PB) provides information regarding organ quality. Most commonly cited reason for organ discard is…2019 American Transplant Congress
Treatment Modality Affects Outcomes of Recurrent Hepatocellular Carcinoma Following Liver Transplantation: A US Multicenter Analysis of 2786 Patients
*Purpose: Recurrent hepatocellular carcinoma (HCC) following liver transplantation (LT) has a poor prognosis. We evaluated the impact of treatment modalities on post-recurrence survival.*Methods: Adult patients…2019 American Transplant Congress
Immunomics of Renal Allograft Acute T-Cell Mediated Rejection Biopsies of Tacrolimus- and Belatacept- Treated Patients
*Purpose: Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin inhibitor based therapy, however…2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…2019 American Transplant Congress
Interleukin-27 is Required for Donor Specific Antibody Production in Response to Heart Allograft Transplantation
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Interleukin-27 (IL-27), a member of IL-12 cytokine family, is involved in both pro- and anti-inflammatory immune responses. Previously we reported that B cell derived…2019 American Transplant Congress
Trends in Vascularized Composite Allograft Transplantation in the United States
*Purpose: Characterize patterns in VCA transplantation in the U.S.*Methods: Analyses include all VCA recipients in the U.S through October 2018 and all VCA candidates between…
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