Am J Transplant, Volume 19, Suppl 3 Archives - Page 79 of 214 - ATC Abstracts

2019 American Transplant Congress
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Solid Organ Transplant Recipients at an Academic Medical Center
J. S. Kerr, N. Law, S. Aslam
Center for Transplantation, University of California, San Diego Health System, La Jolla, CA
*Purpose: In the United States, the incidence of Clostridium difficile infection (CDI) has increased remarkably and remains a significant burden in the solid organ transplant…
2019 American Transplant Congress
Myeloid AXL Promotes Cardiac Allograft Vasculopathy
K. E. Glinton¹, X. Yeap¹, Z. J. Zhang², X. Luo³, E. B. Thorp¹
¹Pathology, FCVRRI, Northwestern University - Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University - Feinberg School of Medicine, Chicago, IL, ³Duke Transplant Center, Duke University School of Medicine, Durham, NC
*Purpose: Cardiac Allograft Vasculopathy (CAV) is a significant contributor to long term transplant rejection, despite advances in immunotherapy. Reactivity to alloantigen presentation may occur by…
2019 American Transplant Congress
Dual Targeting Desensitization with Carfilzomib Plus Lulizumab Significantly Prolongs Kidney Transplant Survival in Allosensitized Nonhuman Primates
P. M. Schroder, R. Schmitz, Z. Fitch, B. Ezekian, J. Yoon, A. Choi, A. Barbas, F. Leopardi, B. Collins, J. Kwun, S. J. Knechtle
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized patients are difficult to transplant due to pre-formed immunity against MHC antigens; thus, new strategies for desensitization are needed to improve outcomes in…
2019 American Transplant Congress
Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside
K. Nakamura, S. Kageyama, T. Ito, H. Hirao, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…
2019 American Transplant Congress
What Are You Smoking? The Impact of Donor Drug Use on Long Term Survival Post-Transplant
D. A. Baran¹, A. Long¹, J. T. Lansinger², H. Copeland³, J. M. Herre¹, W. Old¹, G. Zeevi¹, C. Barreiro¹, C. Kemp¹, B. H. Smith¹, K. Stelling¹, A. Ingemi¹, P. Bourassa¹, J. Philpott¹
¹Sentara Heart Hospital, Norfolk, VA, ²Eastern Virginia Medical School, Norfolk, VA, ³Division of Cardiothoracic Surgery, University of Mississippi Medical Center, Jackson, MS
*Purpose: Drug use is a common aspect in the history of heart transplant donors. Whether prior or current drug use is associated with inferior post…
2019 American Transplant Congress
Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
A. Kirk¹, H. Xu¹, A. Ghali², A. Mehta², A. Guasch²
¹Surgery, Duke University, Durham, NC, ²Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
2019 American Transplant Congress
A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients
C. N. Kotton¹, M. Schwendinger², G. Thiry³, B. De Vos⁴, F. De Boever⁵, G. Leroux-Roels⁶, A. Lilja⁷
¹Infectious Diseases Division, Boston, MA, ²Hookipa Biotech AG, Vienna, Austria, ³Hookipa Biotech GmbH, VIenna, Austria, ⁴Bejamad sprl/bvba, Beersel, Belgium, ⁵Centrum voor vaccinologie (CEVAC), Gdent, Belgium, ⁶Centrum voor vaccinologie (CEVAC), Gent, Belgium, ⁷Hookipa Biotech GmbH, Vienna, Austria
*Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
2019 American Transplant Congress
Standardizing Blood Pressure Measurement across 17 Pediatric Transplant Centers: The Improving Renal Outcomes Collaborative
M. E. Seifert¹, R. Garro², R. P. George², G. Barletta³, C. W. Belsha⁴, A. Chaudhuri⁵, J. W. Goebel⁶, L. Wickman⁷, D. Matossian⁸, J. Misurac⁹, C. Nailescu¹⁰, C. R. Nguyen¹¹, M. Pearl¹², A. Pollack¹³, C. S. Pruette¹⁴, P. Singer¹⁵, P. S. Verghese¹⁶, B. A. Warady¹⁷, D. S. Dahale¹⁸, D. K. Hooper¹⁸
¹University of Alabama, Birmingham, AL, ²Emory University, Atlanta, GA, ³Phoenix Children's Hospital, Phoenix, AZ, ⁴Saint Louis University, St. Louis, MO, ⁵Stanford University, Stanford, CA, ⁶Children's Hospital Colorado, Aurora, CO, ⁷Michigan Medicine, Ann Arbor, MI, ⁸Lurie Children's Hospital, Chicago, IL, ⁹University of Iowa, Iowa City, IA, ¹⁰Riley Hospital For Children, Indianapolis, IN, ¹¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ¹²UCLA Mattel Children’s Hospital, Los Angeles, CA, ¹³Seattle Children's Hospital, Seattle, WA, ¹⁴Johns Hopkins University, Baltimore, MD, ¹⁵Cohen Children's Medical Center, New Hyde Park, NY, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Children's Mercy Kansas City, Kansas City, MO, ¹⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: We report efforts from the Improving Renal Outcomes Collaborative (IROC) to standardize appropriate BP measurement across 17 pediatric kidney transplant centers.*Methods: 17 centers participated…
2019 American Transplant Congress
Advanced Immunological T-cell Ageing Defined by a Very Low Thymic Function Identifies Patients with a Substantial Increased Risk for Long-Term Mortality after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: End-stage renal disease is associated with premature ageing of the T-cell immune system. At the time of kidney transplantation the average biological age of…
2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
J. Zuber¹, O. Boyer¹, B. Neven¹, R. Berthaud¹, M. Ould Rabah¹, I. Jollet², V. Renac², F. Pirenne², S. Gross², R. Djoudi², P. Tiberghien², J. Taupin³, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Etablissement Français du Sang, Paris, France, ³Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…