Am J Transplant, Volume 19, Suppl 3 Archives - Page 72 of 214 - ATC Abstracts

2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
B. Swearingen¹, S. Graves², R. Storb², D. W. Mathes¹
¹University of Colorado School of Medicine, Aurora, CO, ²Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation
L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
IE-1 Specific T Cell Receptor Repertoire Diversity and Protection against CMV Reactivation
M. Lucia Perez¹, F. Rubelt¹, S. Busque¹, C. O. Esquivel¹, S. M. Krams¹, O. Bestard², O. M. Martinez¹
¹Surgery, Stanford University School of Medicine, Stanford, CA, ²Nephrology, University of Barcelona, L'Hospitalet de Llobregat, Spain
*Purpose: Cytomegalovirus (CMV) is a major complication for organ transplant recipients. T cells reacting to the CMV antigen immediate-early (IE-1) are key in controlling reactivation…
2019 American Transplant Congress
Pre-Transplant Donor-Specific IFN-γ ELISPOT as a Predictor of Allograft Rejection: A Diagnostic Test Accuracy Meta-Analysis
S. Farouk¹, I. Gandolfini², N. Montero³, E. Crespo⁴, M. Jarque⁴, M. Meneghini⁴, U. Maggiore², O. Bestard³, P. Cravedi¹
¹Medicine, Division of Nephrology, Icahn School of Medicine at Mt. Sinai, New York, NY, ²Centro Trapianti Rene-Pancreas, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy, ³Nephrology, Bellvitge University Hospital, Barcelona, Spain, ⁴Experimental Nephrology Laboratory. IDIBELL, Barcelona, Spain
*Purpose: Pre-transplant interferon-γ (IFN-γ) enzyme-linked immunospot (IFN- γ ELISPOT) has been proposed as a tool to quantify alloreactivity of memory T cells and estimate the…
2019 American Transplant Congress
Utility of AlloSure Monitoring in Simultaneous Kidney and Pancreas Recipients
J. A. Klein, A. Gupta, P. Budhiraja, D. Cibrik
Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Determine utility and efficacy of donor-derived cell free DNA (dd-cfDNA) monitoring in simultaneous kidney and pancreas (SPK) recipients compared to kidney transplant alone (KTA).…
2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
J. Harmon, V. Korutla, L. Korutla, R. Hu, S. Rostami, A. Habertheuer, P. Zielinski, A. Freas, C. Ram, A. Naji, M. Davis, P. Vallabhajosyula
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…
2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
K. Sablik¹, K. Jordanova², M. Clahsen-van Groningen¹, M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…
2019 American Transplant Congress
Unifying Interpretation of Molecular HLA Typing Data between the Solid Organ Allocation Match Run and Virtual Crossmatch
N. Kaur¹, E. Kransdorf², M. Pando³, L. Gragert¹
¹Tulane University School of Medicine, New Orleans, LA, ²Cedars-Sinai Heart Institute, Los Angeles, CA, ³Baylor Scott & White, Temple, TX
*Purpose: Virtual crossmatch compares a transplant candidate’s HLA antibody assay results to the HLA typing of the donor before an organ offer is accepted. While…