Am J Transplant, Volume 19, Suppl 3 Archives - Page 54 of 214 - ATC Abstracts

2019 American Transplant Congress
Pathologic Vascular Invasion Correlates with Worse Outcome in Hepatoblastoma Patients Treated with Liver Transplantation – A Hepatoblastoma Transplant Consortium Study
T. H. Malik¹, H. Zhu², T. Ha³, S. Commander⁴, C. Trautz⁵, R. Sindhi⁵, S. Kim⁶, K. Vakili⁶, N. Vachharajani⁷, W. Chapman⁷, A. Griesemer⁸, M. Martinez⁸, J. A. Goss⁹, S. Vasudevan¹⁰
¹Baylor College of Medicine, Houston, TX, ²Texas Children's Hospital, Houston, TX, ³Department of Surgery, Baylor College of Medicine, Houston, TX, ⁴Department of Surgery, Duke University School of Medicine, Durham, NC, ⁵Department of Surgery, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Surgery, Boston Children's Hospital, Boston, MA, ⁷Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, ⁸Department of Surgery, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, ⁹Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, ¹⁰Department of Pediatric Surgery, Texas Children's Hospital, Houston, TX
*Purpose: Orthotopic liver transplant (OLTx) is the most common method to treat unresectable hepatoblastoma (HB) in children. There is limited data focusing on the outcomes…
2019 American Transplant Congress
The Important Roles of Dendritic Cells in Transplantation
T. Ueno¹, M. M. McGrath¹, M. Y. Yeung¹, S. Cai¹, Y. Ueno¹, T. Yokoyama², Y. Kihara², O. Konno², Y. Nakamura², H. Iwamoto², A. K. Chandraker¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, ²Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
2019 American Transplant Congress
Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation
J. Zuber¹, O. Boyer¹, B. Neven¹, E. Six², R. Berthaud¹, M. Ould Rabah¹, S. Sobrino², C. Lagresle², I. André-Schmutz², M. Cavazzana¹, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Inserm UMRS 1163, Paris, France
*Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…
2019 American Transplant Congress
Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice
W. Lee, Y. Wang, T. Wu, C. Cheng, C. Lee, T. Wu, H. Chou, K. Chan
General Surgery, Chang-gung Hospital, Taoyuan, Taiwan
*Purpose: Currently, aged people are increasing and more and more aged people have organ transplantation. The immunity in aged people is weaker than young people.…
2019 American Transplant Congress
Generation of Human/Pig Hybrid Thymus to Achieve Immune Tolerance to Pig Antigens with Optimal Immune Function
M. Khosravi Maharlooei, H. Li, M. Holzl, A. Vecchione, A. Misra, A. Ruiz, R. Madley, G. Nauman, N. Danzl, G. Zhao, K. Yamada, M. Sykes
Columbia University, New York, NY
*Purpose: Thymus transplantation is a promising approach to induce T-cell tolerance for xenotransplantation. We have previously shown that humanized mice generated with human hematopoietic stem…
2019 American Transplant Congress
FK506 Influence Glucose Metabolism by Short Chain Fatty Acid
W. Jiao¹, Z. Zhang¹, L. Liu², X. Hu¹
¹Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China, ²GI Divison, West China Hospital, Beijing, China
*Purpose: FK506 is one of the most common immunosuppressant drugs in organ transplantation, which have been demonstrated to cause glucose metabolism disorder and alterd the…
2019 American Transplant Congress
Changes in Kidney Offer Acceptance for Pediatric Candidates Post-KAS
M. Bowring, K. Jackson, J. Garonzik-Wang, D. Segev, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose:Stakeholders have expressed concerns regarding kidney transplant rates for pediatric candidates under KAS. To better understand what might be driving potential declines in access, we…
2019 American Transplant Congress
Anti-HLA IgM Antibodies Are Reduced in Highly-HLA Sensitized Patients Transplanted after Imlifidase (IdeS) Treatment
X. Zhang¹, S. Jordan²
¹HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA
*Purpose: Immunoglobulin-degrading enzyme from Streptococcus pyogenes (IdeS, Imlifidase) has been used to reduce antibody levels to promote transplant of highly sensitized patients. In vitro experiments…
2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…
2019 American Transplant Congress
MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels
J. Merola¹, M. Reschke², L. Qin¹, S. Spindler¹, R. W. Pierce³, T. D. Manes⁴, G. Li¹, L. Bracaglia², N. Kirkiles-Smith⁴, T. Baltazar⁴, W. Saltzman², G. T. Tietjen¹, G. Tellides¹, J. S. Pober⁴
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, ³Pediatrics, Yale School of Medicine, New Haven, CT, ⁴Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…