Am J Transplant, Volume 19, Suppl 3 Archives - Page 54 of 214 - ATC Abstracts

2019 American Transplant Congress
Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection
M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…
2019 American Transplant Congress
TCR Transgenes to Understand Human Xenotolerance Induction
G. Nauman, C. Borsotti, N. Danzl, M. Khosravi-Maharlooei, H. Li, E. Chavez, Y. Yang, M. Sykes
Columbia Center for Translational Immunology, New York, NY
*Purpose: Swine thymus transplantation is a promising approach to clinical tolerance for pig-to-human xenotransplantation. In humanized mice, a swine thymus graft supports de novo selection…
2019 American Transplant Congress
Validation Of The Optimized Prediction Of Mortality (Opom) Machine Learning Model For Non-hepatocellular Carcinoma Candidates Awaiting Liver Transplant
L. Lau¹, X. Xie², F. Jia², P. D. Greig¹, T. C. Chan²
¹Multi-Organ Transplant, Department of Surgery, University of Toronto, Toronto, ON, Canada, ²Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada
*Purpose: Currently the Model for End-Stage Liver Disease (MELD) is used to rank candidates for liver transplant in many jurisdictions. However, MELD does not provide…
2019 American Transplant Congress
CMV Risk Status Remains a Relevant Risk Factor for Long-Term Outcomes
G. Karadkhele, W. Zhang, C. P. Larsen
Emory University, Atlanta, GA
*Purpose: Intensification of immunosuppression using T cell depleting induction has reduced rates of acute cellular rejection after kidney transplantation. Belatacept, a first in class T…
2019 American Transplant Congress
Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients
J. Kwun, B. Ezekian, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Yi, S. Knechtle
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Broad human leukocyte antigen sensitization is a significant barrier to successful solid organ transplantation. Sensitized patients have poor access to donor organs, high wait…
2019 American Transplant Congress
Frailty Associated with Increased Rates of Acute Cellular Rejection within 3 Months after Liver Transplantation
L. Fozouni, A. Lebsack, Y. Mohamad, C. Freise, P. Stock, J. Lai
UCSF, San Francisco, CA
*Purpose: Frailty, a state of decreased physiologic reserve and increased vulnerability to health stressors, has an inflammatory biologic basis and has been associated with dysregulation…
2019 American Transplant Congress
A Molecular Analysis of Graft Survival in the INTERHEART Study
P. Halloran¹, J. Reeve and the INTERHEART investigators²
¹University of Alberta, Edmonton AB, AB, Canada, ²ATAGC, University of Alberta, Edmonton AB, AB, Canada
*Purpose: Rejection is a major cause of graft loss in heart and kidney transplants. The principal diagnosis associated with risk in kidneys is antibody-mediated rejection…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla³, K. Hippen⁴, B. Blazar⁴, S. Schwab⁵
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴U.Minnesota, Minneapolis, MN, ⁵NYU, NY, NY
*Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…
2019 American Transplant Congress
Low Frequency Of Canonical Human Leukocyte Antigen Alloimmunization In Heart Transplantation Candidates With Ventricular Assist Devices
G. K. Mahowald¹, S. L. Saidman¹, G. Lewis², V. Pattanayak¹
¹Pathology, Massachusetts General Hospital, Boston, MA, ²Cardiology, Massachusetts General Hospital, Boston, MA
*Purpose: Screening for anti-HLA antibodies in heart transplantation candidates is complicated by transfusions as well as by the presence of ventricular assist devices (VADs), which…
2019 American Transplant Congress
Early Outcomes Comparing Two Steroid-Avoidance Protocols in Pediatric Renal Transplantation
D. Puliyanda¹, H. Pizzo¹, N. Rodig², M. Somers²
¹Cedars-Sinai Med Ctr, Los Angeles, CA, ²Pediatric Nephrology, Boston Childrens Hospital, Boston, MA
*Purpose: Steroid-avoidance in pediatric kidney transplants (txs) was found effective and safe with daclizumab induction. Upon daclizumab’s discontinuation, lymphocyte-depleting agents became used in this setting,…