Am J Transplant, Volume 19, Suppl 3 Archives - Page 52 of 214 - ATC Abstracts

2019 American Transplant Congress
Is HLA Donor-Specific Antibody (DSA)-C3d+ Assay a Potential Predictor of Subclinical Antibody Mediated Damage in the Renal Graft?
A. G. Contreras¹, M. I. Solis-G¹, C. Ramirez-Espinoza¹, J. Hernandez-Rosales², M. Vilatoba-Chapa¹, R. Cruz-Martínez¹, J. Granados¹, L. E. Morales-Buenrostro³, J. Alberú¹, J. M. Arreola-Guerra⁴
¹Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ²Department of Histocompatibility, Laboratorio Clinico del Campestre, Mexico City, Mexico, ³Nephrology-Mineral Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ⁴Internal Medicine, Centenario Hospital Miguel Hidalgo, Mexico City, Mexico
*Purpose: The Aim of the study was to explore the predictive value of the C3d assay for tissue damage in kidney transplant recipients (KTR) in…
2019 American Transplant Congress
Nivolumab-Induced Rejection of a Liver Allograft: PD-1 Inhibition Thwarts Liver Allograft Resistance to Humoral Rejection
B. T. Lee, H. Han, S. Chopra, A. J. Ahearn
Surgery, USC Keck School of Medicine, Los Angeles, CA
*Purpose: Checkpoint inhibitor therapy with Programmed cell death protein (PD-1) inhibitors has recently been FDA approved for the treatment of several malignancies. However, it has…
2019 American Transplant Congress
Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients
A. D. Desai¹, G. J. Kavalam², A. Chandraker², S. Tripathi²
¹1Harvard Summer Research Program for Kidney Medicine, Harvard Medical School,, Boston, MA, ²Schuster Family Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells and NK cells. TIGIT has…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
Racial and Ethnic Differences in Physician Trust and Hypertension Treatment Adherence among Living Kidney Donors in the United States
J. S. Wilson Jr¹, L. Cooper², M. Johnson², M. Waldram², Y. Yu², J. Perkins², D. Crews², N. Lacy³, M. Henderson², A. Massie², K. Lentine⁴, D. Segev², T. Purnell²
¹Williams College, Williamstown, MA, ²Johns Hopkins University, Baltimore, MD, ³North Carolina State University, Raleigh, NC, ⁴St. Louis University, St. Louis, MO
*Purpose: Among living kidney donors who develop hypertension (HTN), little is known about racial/ethnic differences in the relationship between physician trust levels and adherence to…
2019 American Transplant Congress
Forensic Transplant Psychiatry: Ethical Issues and the Unique Assessment Needs of Candidates with Forensic Psychiatric Problems
D. Banayan, S. Gershan
Rush University Medical Center, Chicago, IL
*Purpose: To establish what, if any, currently available guidelines or assessment instruments can help transplant programs perform fair, and objective evaluations of patients with forensic…
2019 American Transplant Congress
Impact of Everolimus Therapy on HIV Persistence and Gene Expression in Transplant Patients
A. Zarinsefat¹, C. Schreiner¹, C. Cameron², S. Chu¹, M. P. Busch¹, T. Liegler¹, S. G. Deeks¹, T. J. Henrich¹, P. G. Stock¹
¹UC San Francisco, San Francisco, CA, ²Case Western Reserve University, Cleveland, OH
*Purpose: mTOR is a key regulatory kinase that controls cell-cycle progression. mTOR inhibitors have been shown to reduce expression of CCR5 and promote viral transcriptional…
2019 American Transplant Congress
Exploring Perceptions of Organ Procurement: Need for a Formal Medical Student Curriculum
L. Winer¹, M. Vivero², B. Scully³, A. Cortez¹, A. Kassam¹, J. Kuethe¹, R. Nowygrod³, J. Emond³, R. C. Quillin III¹
¹Surgery, University of Cincinnati, Cincinnati, OH, ²Surgery, Brigham and Women’s Hospital, Boston, MA, ³Surgery, Columbia University, New York City, NY
*Purpose: Medical student participation in organ procurement provides early exposure to surgery and may inspire donor advocacy. We evaluated medical students’ experiences with an organ…
2019 American Transplant Congress
The Treatment of Hepatitis C Virus (HCV) with Direct Acting Antiviral (DAA) Treatment in the Post Orthotopic Liver Transplant (OLT) Patient is Safe and Efficacious
P. Brown¹, Z. Demertzis¹, S. Jafri²
¹Internal Medicine, Henry Ford Health System, Detroit, MI, ²Gastroenterology and Hepatology, Henry Ford Health System, Detroit, MI
*Purpose: Chronic HCV is one of the leading causes for end stage liver disease and liver transplantation. Since their introduction, DAAs have revolutionized the treatment…
2019 American Transplant Congress
Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes
T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…