2019 American Transplant Congress
Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants
*Purpose: The main problem with kidney transplantation is the possibility of rejection, which is classified as either antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) depending…2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…2019 American Transplant Congress
Identification of Antibodies Reactive to Vimentin in a Rat Kidney Transplant Model of Chronic Antibody-Mediated Rejection
University of Wisconsin Madison, Madison, WI
*Purpose: As many as 30% of patients with chronic active antibody-mediated rejection (cAMR) lack HLA-specific antibodies. Recently, researchers identified clinical relevance of non-HLA antibodies, including…2019 American Transplant Congress
Psychosocial Factors and Medication Adherence among Recipients of Vascularized Composite Allografts
1Johns Hopkins University, Baltimore, MD, 2Christine M Kleinert Institute, Louisville, KY
*Purpose: Psychosocial factors are important predictors of medication adherence, and subsequently graft survival, in solid organ transplantation. Early experiences suggest this may be the case…2019 American Transplant Congress
Functional Characterization of Orthotopic Hind-Limb Transplants in Rats
Comprehensive Transplant Center and Department of Surgery, Northwestern University, Chicago, IL
*Purpose: Vascularized composite allotransplantation (VCA) is a valid therapeutic option for patients with non-salvageable injuries such as severe burns or limb amputation. The immune response…2019 American Transplant Congress
Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy
*Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…2019 American Transplant Congress
Withaferin A Shifts Circulating Lymphocytes toward Protective T Cell Subsets and Prolongs Islet Allograft Survival in a Mouse Transplant Model
*Purpose: : Immunosuppression protocols improve the efficacy of allogeneic islet transplantation. However, decline in islet graft function and toxicities imposed by current immunosuppressant drugs remain…2019 American Transplant Congress
External Validation of Donor-Derived Cell-Free DNA to Detect Rejection in Kidney Transplant Recipients
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA; Allosure®, CareDx) became Medicare-reimbursable in the United States in October, 2017 for the detection of rejection in kidney transplant recipients…2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
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