Am J Transplant, Volume 19, Suppl 3 Archives - Page 44 of 214 - ATC Abstracts

2019 American Transplant Congress
Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death
S. Balaji¹, B. Fuhrmann², D. Lian³, H. Diao³, S. Ma³, Z. Zhang³, A. M. Jevnikar³
¹Physiology, Western University, London, ON, Canada, ²Microbiology and Immunology, Western University, London, ON, Canada, ³London Health Sciences Centre, London, ON, Canada
*Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
2019 American Transplant Congress
Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function
S. Aiello, P. Rodriguez, N. Azzollini, F. Casiraghi, M. Noris, G. Remuzzi, A. Benigni
Mario Negri Institute, Ranica, Italy
*Purpose: Post-transplant (tx) IRI activates TLR/IL-1R on tissue resident leukocytes initiating innate immune response. We studied how donor renal resident macrophages (rMF) respond to post-tx…
2019 American Transplant Congress
Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function
P. West-Thielke¹, J. Oberholzer², Y. Wang³
¹University of Illinois, Chicago, IL, ²University of Virgina, Charlottesville, VA, ³University of Virginia, Charlottesville, VA
*Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…
2019 American Transplant Congress
Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay
A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹
¹Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, ²Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, ³Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada
*Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…
2019 American Transplant Congress
Post-Reperfusion Hepatic Beta-Catenin Activation Regulates Graft Damage, Inflammatory Responses and Transplant Outcomes
H. Hirao, K. Kadono, S. Kageyama, K. Nakamura, T. Ito, J. Aziz, K. J. Dery, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI), an innate-immune driven hepatic inflammation response, represents a major risk factor of early allograft dysfunction (EAD) and rejection in liver…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
2019 American Transplant Congress
‘Back-to-Base’ Normothermic Clinical Liver Perfusion – Cold before NMP Does Not Compromise Protective Benefit
K. Dajani, M. Bral, D. leon Izquierdo, D. Bigam, N. Kneteman, J. Shapiro
University of Alberta Hospital, Edmonton, AB, Canada
*Purpose: In previous clinical studies utilizing normothermic ex situ liver machine preservation, perfusion was initiated rapidly following organ procurement using a portable system transported to…
2019 American Transplant Congress
Impact of Extremely Prolonged Cold Ischemia Time in Combination with AKI on Kidney Transplantation Outcome – A Single Center Experience
N. Sharma, Z. Haddad, Y. Qazi
USC, Los Angeles, CA
*Purpose: Donor kidneys with prolonged cold ischemia time (CIT) and acute kidney injury (AKI) are often rejected on the view they do not achieve successful…
2019 American Transplant Congress
Temporal Trends of First-Year Mortality on the Adult Kidney-Only Wait List in the United States
F. Tedla, A. Gruessner, I. Puri, A. Brar, N. Sumrani, D. John, J. Renz, R. Gruessner, M. Salifu
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Evaluation of kidney transplant candidacy must balance risk of mortality with and without transplant. Trends in first-year mortality could inform patterns of risk avoidance…
2019 American Transplant Congress
Eculizumab in Kidney Transplant Recipients with Atypical Hemolytic Uremic Syndrome – Single Center Experience
A. Bhalla, S. Alasfar, N. Alachkar
Division of Transplant Nephrology, Johns Hopkins Hospital, Baltimore, MD
*Purpose: Atypical hemolytic uremic syndrome (aHUS) is caused by genetic mutations of components of the alternative complement pathway in 60-70% of cases; and has a…