2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…2019 American Transplant Congress
De Novo Complement-Activating Donor Specific Antibodies in Pediatric Renal Transplant Recipients Are Highly Responsive to Therapy
Pediatric Nephrology, Stanford, Los Altos, CA
*Purpose: Antibody mediated rejection remains a common cause for pediatric renal allograft loss. After recognizing that graft failure was more common in our pediatric renal…2019 American Transplant Congress
Regional Disparities In The Transplant Rates Across Unos Regions Pre- And Post-kidney Allocation System Policy Implementation
Massachusetts General Hospital, Boston, MA
*Purpose: Geographic distribution of organs for transplant is a critical component of the Organ Procurement and Transplantation Network (OPTN) policies. However, there is no single…2019 American Transplant Congress
Safety and Efficacy of Imlifidase in Highly-Sensitized Kidney Transplant Patients: Results from a Phase 2 Study
*Purpose: Many patients eligible for kidney transplantation are sensitized to allo-HLA antigens and face prolonged waiting times and increased mortality. The presence of donor specific…2019 American Transplant Congress
Early Tacrolimus Trough Concentration Variability Could Predict Rejection in Pediatric Liver Transplantation: A Single-Center and Retrospective Research
Renji Hospital, Shanghai, China
*Purpose: With great development in immunosuppressive therapy, the long-term outcomes and survival time in patients who received solid organ transplantation have been improved remarkably. The…2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…2019 American Transplant Congress
Identification and Determinants of Cardiac Allograft Vasculopathy Trajectories after Heart Transplantation
*Purpose: CAV is a major contributor of heart transplant recipient’s mortality. However, little is known about CAV long-term evolution profiles and their determinants. Such information…2019 American Transplant Congress
Eculizumab Deposition in Renal Transplants
*Purpose: Eculizumab is a recombinant humanized IgG monoclonal antibody that inhibits C5, thereby preventing the activation of C5a and formation of membrane attack complex C5b-C9.…
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