Am J Transplant, Volume 19, Suppl 3 Archives - Page 21 of 214 - ATC Abstracts

2019 American Transplant Congress
Novel Flow-Based Assay to Identify Allo-Specific T Cell Exhaustion
N. Tanimine¹, C. Rickert¹, K. Lee¹, K. Deng¹, N. Feeney¹, C. Leguern¹, B. Burrell², J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Immune Tolerance Network, Bethesda, MD
*Purpose: A recent, multi-center immunosuppression withdrawal trial in liver transplant recipients unexpectedly revealed time post-transplant as an important predictor for operational tolerance. We hypothesize that…
2019 American Transplant Congress
Lack of Response to Tocilizumab in Kidney Transplants with Chronic Antibody-Mediated Rejection
D. Kumar¹, F. Safavi¹, R. Sandhu¹, P. Halloran², I. Yakubu¹, M. Levy¹, I. Moinuddin¹, P. Kimball¹, L. Kamal¹, A. King¹, H. Massey¹, G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Chronic antibody mediated rejection (cAbMR) is a major cause of long-term kidney transplant (KT) loss. Traditional therapies for cAbMR have unclear efficacy with significant…
2019 American Transplant Congress
The Impact of Eplet Mismatches on Kidney Transplant Outcome: A Single-Center Cohort Study
A. Senev¹, M. Coemans¹, V. Van Sandt², B. Sprangers³, D. Kuypers³, M. Emonds², M. Naesens³
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium, ³University Hospitals Leuven, Leuven, Belgium
*Purpose: It has been shown that HLA-matching at classic antigen-level for HLA-A, -B and -DRB1 loci, provides benefits in matching and outcome after solid organ…
2019 American Transplant Congress
Renal Transplantation in Patients Older Than 60 Years with High Comorbidity. Is There a Survival Benefit? A Multicenter Study in Argentina
G. D. Fragale¹, G. A. Laham², L. Bisignano³, A. Antik³, P. M. Raffaele⁴, M. Fortunato⁴, H. Trimarchi⁵, V. Pomeranz⁵, R. Maldonado⁶, N. Matamala⁶, N. C. Imperiali⁷, M. C. Giordani⁷, M. F. Taylor⁸, J. M. Ciappa⁸, J. L. De La Fuente⁹, S. Naser¹⁰, G. Soler Pujol²
¹Nephrology, Hospital Universitario Austral, Derqui, Argentina, ²Nephrology, CEMIC, Buenos Aires, Argentina, ³INCUCAI, Buenos Aires, Argentina, ⁴Fundacion Favaloro, Buenos Aires, Argentina, ⁵Hospital Britanico de Buenos Aires, Buenos Aires, Argentina, ⁶Clinica Velez Sarsfield, Cordoba, Argentina, ⁷Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Crai Sur, Buenos Aires, Argentina, ⁹Hospital Privado Universitario de Cordoba, Cordoba, Argentina, ¹⁰Hospital Privado Universitario de Cordoba, Buenos Aires, Argentina
*Purpose: The impact of renal transplantation (RT) in the elderly with comorbid conditions is a matter of concern. Our aim was to assess the impact…
2019 American Transplant Congress
Dosing and Exposure over 2 Years with LCP-Tacrolimus (LCPT) vs. Immediate-Release Tacrolimus (IR-Tac) in De Novo Kidney Transplantation
K. Budde¹, S. Bunnapradist², S. Patel³, D. Stevens³, U. Meier-Kriesche³, B. Suwelack⁴
¹Charité University Medicine Berlin, Berlin, Germany, ²UCLA Medical Center, Los Angeles, CA, ³Veloxis Pharmaceuticals Inc, Cary, NC, ⁴University Hospital of Münster, Münster, Germany
*Purpose: A prospective study demonstrated safe and efficacious use of LCPT in de novo kidney transplantation. This study aims to evaluate tacrolimus trough levels and…
2019 American Transplant Congress
Outcomes of ABO Incompatible Transplant on Steroid Free Immunosuppression
A. Wang, D. Mishler, T. Taber, M. Yaqub, A. Sharfuddin, W. Goggins, O. Adebiyi
Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: ABO incompatible (ABOi) kidney transplant (KTx) was introduced to expand donor organ pool. However it is also an immunologically high-risk procedure requiring pre-transplant antibody…
2019 American Transplant Congress
Difference in DSA Formation between Tacrolimus-XR and Tacrolimus-IR
J. Hagopian¹, C. Carthon¹, S. January¹, A. Gharabagi², R. Delos Santos³, T. Horwedel⁴
¹Barnes-Jewish Hospital, Saint Louis, MO, ²St. Louis College of Pharmacy, Saint Louis, MO, ³Washington University, Saint Louis, MO, ⁴Veloxis Pharmaceuticals, Inc., Cary, NC
*Purpose: Donor specific antibodies (DSA), whether pre-formed or developed de novo after kidney transplantation, have been associated with acute and chronic antibody mediated rejection, transplant…
2019 American Transplant Congress
Sequential Liver Kidney Transplant Has Comparable Outcomes As Combined Liver Kidney Transplant Except For Ckd 5 In Patient With Cld With Ckd In Live Donor Program- Retrospective Analysis Of 2182 Cases
S. Verma, S. Naganathan, S. Gupta
Center for Liver and Biliary Sciences, Max Superspeciality hospital, New Delhi, India
*Purpose: Chronic Kidney disease (CKD) is common in patient with Chronic liver disease (CLD). It is difficult to distinguish between CKD and Hepatorenal syndrome (HRS)…
2019 American Transplant Congress
The Risks Are Not Always The Same; Peak Timing Of Risk In Liver Transplantation
K. Sasaki, J. McVey, D. Firl, K. Okubo, M. Fujiki, T. Diago Uso, D. Kwon, B. Eghtesad, C. Quintini, C. Miller, F. Aucejo, K. Hasimoto
Cleveland Clinic, Cleveland, OH
*Purpose: Numerous risk factors are known to affect liver transplantation (LT). Previous studies suggest that a combination of favorable and unfavorable factors is essential in…
2019 American Transplant Congress
Portal Vein Thrombosis Discovered at Liver Transplant: Barrier to Success
J. Seltman¹, M. Kazimi², J. Duque³, R. Cross², A. Ray², T. Ommert², R. A. Rubin²
¹Mercer University Medical School, Macon, GA, ²Transplantation, Piedmont Transplant Institute, Atlanta, GA, ³Piedmont Heart Institute, Atlanta, GA
*Purpose: Portal vein thrombosis (PVT) present at listing or diagnosed while listed enables potential treatment pre-liver transplant (OLT). Main PVT at OLT (mPVT) complicates surgeries…