Am J Transplant, Volume 19, Suppl 3 Archives - Page 209 of 214 - ATC Abstracts

2019 American Transplant Congress
Impact Of Selective Cd28 Blockade On Protective Immunity To A Murine Epstein-Barr Virus Homolog
R. L. Crepeau, J. A. Elengickal, M. L. Ford
Surgery, Emory University, ATLANTA, GA
*Purpose: CTLA-4Ig blocks CD80/CD86, the ligands for both CD28 and CTLA-4. Thus, in addition to the intended effect of blocking CD28-mediated costimulation, CTLA4-Ig also has…
2019 American Transplant Congress
Defatting Steatotic Rat Livers during Ex Situ Normothermic Perfusion Improves Lactate Clearance and Bile Quality
S. Raigani¹, C. Carroll², S. Cronin², C. Pendexter², I. Rosales³, M. Yarmush¹, K. Uygun¹, H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA, ³Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: Donor livers with moderate-to-severe steatosis are not generally used for transplantation because of poor post-transplant function. Ex situ normothermic machine perfusion (ENMP) provides an…
2019 American Transplant Congress
Effectiveness Of Percutaneous Embolization As Treatment Compared To Nephrectomy For Renal Graft Intolerance Syndrome In Late Graft Failure Patients
S. Kwon, J. Go, S. Park, S. Yoon, J. Kim, I. Moon
Department of Vascular and Transplant Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of
*Purpose: Failed renal allografts left in situ may cause inflammation presenting as graft intolerance syndrome (GIS). But there is no standardization for treatment of a…
2019 American Transplant Congress
Conversion from Calcineurin Inhibitors to Belatacept in Kidney Recipients with Donor-Specific Anti-HLA Antibodies and Calcineurin Inhibitor Nephrotoxicity Decreases the Pathogenicity of Donor-Specific Anti-HLA Antibodies
K. Louis¹, D. Viglietti¹, D. Pievani¹, O. Aubert¹, D. Glotz¹, C. Legendre¹, A. Zeevi², A. Loupy¹, C. Lefaucheur¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Switching from CNI- to Belatacept-based regimen has been associated with improved graft function in low-immunologic risk kidney recipients. We investigated the efficacy and safety…
2019 American Transplant Congress
Lower Extremity Impairment and Frailty among Adults with Diabetes Awaiting Kidney Transplantation
E. Lorenz, A. Kukla, C. Kennedy, R. McCoy, L. Hickson
Mayo Clinic, Rochester, MN
*Purpose: Frailty and lower extremity impairment, both indicators of poor physical performance, are predictive of all-cause mortality among patients awaiting kidney transplantation (KT). Diabetes, the…
2019 American Transplant Congress
Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on Behalf of The NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
I. Shapey¹, A. Summers¹, J. O'Sullivan¹, P. Yiannoullou¹, J. Casey², S. Forbes², M. Rosenthal³, P. Johnson⁴, P. Choudhary¹, J. Bushnell⁵, J. Shaw⁶, N. Hanley¹, T. Augustine¹, M. Rutter¹, D. van Dellen¹
¹University of Manchester, Manchester, United Kingdom, ²University of Edinburgh, Edinburgh, United Kingdom, ³Royal Free Hospital, London, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom, ⁵Southmead Hospital, Bristol, United Kingdom, ⁶University of Newcastle, Newcastle, United Kingdom
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…
2019 American Transplant Congress
Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses
J. Domen, Y. Li
Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO
*Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…
2019 American Transplant Congress
Association between Respiratory Virus Infections and the Development of De Novo HLA Donor-Specific Antibodies in Lung Transplant Recipients
M. I. Ali, J. Hata, J. Mallea, M. Elrefaei
Mayo Clinic, Jacksonville, FL
*Purpose: The detection of de novo donor-specific anti-HLA antibodies (DSA) post lung transplant have been associated with significantly increased risk for antibody-mediated rejection (AMR) and…
2019 American Transplant Congress
Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Paluskievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…