Am J Transplant, Volume 19, Suppl 3 Archives - Page 203 of 214 - ATC Abstracts

2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
I. Shapey¹, A. Summers¹, J. O'Sullivan¹, P. Yiannoullou¹, J. Casey², S. Forbes², M. Rosenthal³, P. Johnson⁴, P. Choudhary¹, J. Bushnell⁵, J. Shaw⁶, N. Hanley¹, T. Augustine¹, M. Rutter¹, D. van Dellen¹
¹University of Manchester, Manchester, United Kingdom, ²University of Edinburgh, Edinburgh, United Kingdom, ³Royal Free Hospital, London, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom, ⁵Southmead Hospital, Bristol, United Kingdom, ⁶University of Newcastle, Newcastle, United Kingdom
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…
2019 American Transplant Congress
Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses
J. Domen, Y. Li
Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO
*Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…
2019 American Transplant Congress
Association between Respiratory Virus Infections and the Development of De Novo HLA Donor-Specific Antibodies in Lung Transplant Recipients
M. I. Ali, J. Hata, J. Mallea, M. Elrefaei
Mayo Clinic, Jacksonville, FL
*Purpose: The detection of de novo donor-specific anti-HLA antibodies (DSA) post lung transplant have been associated with significantly increased risk for antibody-mediated rejection (AMR) and…
2019 American Transplant Congress
Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Paluskievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…
2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
Kidney Transplantation in the Lower-Income Bracket of South Korea; Widening Gap in Accessibility and Inferior Graft Outcome
G. Park¹, S. Park¹, J. Kim¹, M. Yu¹, Y. Kim¹, K. Kim¹, M. Park², Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Severance Hospital, Seoul, Korea, Republic of
*Purpose: Kidney transplant (KT) benefits in various aspects of end-stage renal disease (ESRD) patients. However, the financial burden is one of the main obstacles to…
2019 American Transplant Congress
A Novel Program of Directed Domino and Split Liver Donations Increases Liver Transplants
T. Fishbein, C. Matsumoto, N. Yazigi, R. Satoskar, S. Kaufman, K. Khan, K. Alexander, J. Hawksworth, M. Summer
Medstar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC
*Purpose: Liver transplants have not been performed in directed donor chains as have evolved for kidney transplants. We report an initial experience using domino and…
2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, A. Bozovic¹, V. Kulasingam¹, P. Chen⁴, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹University Health Network, Toronto, ON, Canada, ²Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, ³Krembil Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
2019 American Transplant Congress
Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)
C. Divella¹, A. Stasi¹, R. Franzin¹, F. Sallustio², C. Curci¹, G. Merlotti³, M. Quaglia³, L. Gesualdo¹, V. Cantaluppi¹, G. Castellano¹
¹Emergency and Organ Transplantation, University of Bari, Bari, Italy, ²Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, ³Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
*Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
2019 American Transplant Congress
Trends and Geographic Variation in the Recovery of Organs from Drug-Overdose Deaths with Donor Potential
V. Garcia, D. Stewart, J. Rosendale
Research, UNOS, Richmond, VA
*Purpose: The opioid crisis in the US and related increase in donors that died from drug-intoxication are well-documented. We set-out to estimate the proportion of…