2019 American Transplant Congress
TORC1 Inhibition In Vitro and in a Humanized Mouse Model Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, BWH/Harvard Medical School, Boston, MA
*Purpose: Optimizing Regulatory T cells (Tregs) survival is of utmost importance to maximize the efficacy of utilizing them in adoptive cell therapy. We previously described…2019 American Transplant Congress
Antibody-Suppressor CD8+ T Cells Require CXCR5
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…2019 American Transplant Congress
Opioid and Benzodiazepine Use in Lung Transplant Candidates: A National Survey of Policies and Practices
*Purpose: The opioid epidemic has raised the question of how transplant teams should work with patients who are prescribed opioids. Benzodiazepine use has also received…2019 American Transplant Congress
Butyrate-Producing Gut Bacteria and Future Development of Viral Infections in Kidney Transplant Recipients
1Weill Cornell Medicine, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY
*Purpose: Recent studies suggest that the gut microbiome plays a critical role in protecting its host from infections beyond Clostridium difficile. Notably, butyrate-producing bacteria may…2019 American Transplant Congress
Kidney Transplant Outcomes and Organ Acceptance Practice Patterns: Nationwide Analyses of the US and France
*Purpose: Approximately 3,500 donated kidneys are discarded in the US each year, drawing concern from Medicare and advocacy groups. We hypothesised that more aggressive organ…2019 American Transplant Congress
Infectious Complications of Eculizumab Use in Abdominal Organ Transplant Recipients
*Purpose: The purpose of this study is to identify and characterize infections in abdominal organ transplant recipients related to treatment with eculizumab. Eculizumab (Soliris®) is…2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…2019 American Transplant Congress
The Collaborative Improvement and Innovation Network (COIIN): Impact on Deceased Donor Transplant Rates and Offer Acceptance Practices
1SRTR, Minneapolis, MN, 2OPTN, Richmond, VA, 3OPTN, Minneapolis, MN
*Purpose: The Organ Procurement and Transplantation Network (OPTN) completed the Collaborative Improvement and Innovation Network (COIIN), a study to increase kidney transplants by reducing risk…2019 American Transplant Congress
How Do We Choose? Predicting Utilization Of Cardiac Donors And The Effect Of Era
*Purpose: The number of patients on the heart transplant waitlist continues to rise. However, the rate of organ acceptance is only about 1/3 of all…
American Transplant Congress abstracts