Am J Transplant, Volume 19, Suppl 3 Archives - Page 196 of 214 - ATC Abstracts

2019 American Transplant Congress
Bortezomib Attenuates the Progression of Epithelial to Mesenchymal Transition through Smurf1 Akt mTOR P70S6K Pathway in Rat Allograft Renal Interstitial Fibrosis Model
R. Tan, Z. Wang, S. Fei, Z. Han, J. Tao, X. Ju, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to detect the effects of Bortezomib and Smurf1 in the EMT and allograft renal interstitial fibrosis.*Methods: Biomarkers of EMT, as well…
2019 American Transplant Congress
Deficiency of IRE1a Ameliorates Renal Allograft Injury via Remodeling of Graft-Infiltrating Macrophages
L. Qiu¹, J. Wang¹, X. Yeap¹, S. Han¹, F. Zheng¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Inflammatory macrophages contribute to the development of ischemia-reperfusion injury (IRI) and allograft rejection. However, the underlying mechanisms by which macrophage mediate allograft injury and…
2019 American Transplant Congress
Comparison of Oral Microbiome in Stable vs Declining Kidney Function in Renal Transplant Recipients
J. Wu¹, A. Muthusamy², G. Al-Ghalith³, B. Wu⁴, B. Guo⁴, W. Guan⁴, D. Knights³, W. Oetting⁵, D. Schladt², R. Remmel⁵, P. Jacobson⁵, A. K. Sharma⁶, A. Matas⁷, A. Israni¹, D. Skaar⁸
¹Nephrology, Hennepin Healthcare, Minneapolis, MN, ²Hennepin Health Research Institute, Minneapolis, MN, ³Computer Science, University of Minnesota, Minneapolis, MN, ⁴Biostatistics, University of Minnesota, Minneapolis, MN, ⁵Pharmacy, University of Minnesota, Minneapolis, MN, ⁶Animal Science, University of Minnesota, Minneapolis, MN, ⁷Surgery, University of Minnesota, Minneapolis, MN, ⁸Denistry, University of Minnesota, Minneapolis, MN
*Purpose: Transplantation causes dysbiosis of the oral microbiome of renal transplant recipients and has been correlated with worse allograft outcomes. We hypothesize that there are…
2019 American Transplant Congress
Mesangiopathic Glomerulonephritis in Kidney Transplants
G. Towns, G. Agarwal, S. Ong, R. Mundra, C. Kew
UAB, Birmingham, AL
*Purpose: Describe higher than anticipated prevalence of Mesangiopathic Glomerulonephritis on surveillance biopsies.*Methods: Review of all surveillance biopsies from September 2014 through September 2018 for presence…
2019 American Transplant Congress
The Interaction between Post-Transplant Anemia and Allograft Function in Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Post-transplant anemia (PTA) is one of the common complications, which was observed in about 30% to 40% of kidney transplant recipients. The interaction effect…
2019 American Transplant Congress
Comparison of Planned vs. Unplanned Pregnancies in Female Kidney Transplant Recipients
S. Rao¹, L. A. Coscia², D. Kliniewski², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Health System, Charlottesville, VA, ²Gift of Life Institute, Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: The purpose of this study is to analyze the impact of planned vs. unplanned pregnancies in 897 female kidney transplant recipients.*Methods: Data were collected…
2019 American Transplant Congress
Attitude towards Organ Donation among Medical Students: Relationship to Knowledge and Beliefs
A. Cerrato, M. Salifu, M. Markell
Nephrology/Medicine, SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Lack of knowledge or misunderstanding of organ donation may underlie physician unwillingness to refer patients for organ donation. We examined baseline knowledge and beliefs…
2019 American Transplant Congress
Interpretable Post-Transplant Graft Failure Prediction Using Decision Tree Neural Networks
J. N. Valdez¹, T. Fu¹, J. Hogan², S. Adhikary¹, M. Arenson², R. Zhang², X. Zhang³, K. Li², A. B. Adams², R. E. Patzer², J. Sun¹
¹Georgia Institute of Technology, Atlanta, GA, ²Emory University, Atlanta, GA, ³University of Michigan, Ann Arbor, MI
*Purpose: Various predictive models identify kidney transplant (KTx) recipients at high risk of graft failure (GF), but comparisons across statistical approaches for a full range…
2019 American Transplant Congress
Borderline Changes in Kidney Allografts Represents a Non-Homogenous Cohort with Different Outcome
P. Hruba¹, J. Maluskova¹, Z. Krejcik², M. Merkerova-Dostalova², V. Stranecky³, J. Klema⁴, K. Osickova¹, M. Wohlfahrtova¹, E. Honsova¹, O. Viklicky¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Institute of Hematology and Blood Transfusion, Prague, Czech Republic, ³Institute of Inherited Metabolic Disorders, Prague, Czech Republic, ⁴Czech Technical University, Prague, Czech Republic
*Purpose: Borderline changes (BL) represent a frequent histological finding in kidney allograft with unclear prognosis.*Methods: In this single center, retrospective, observational study, the BL were…
2019 American Transplant Congress
Outcome of Treated Cellular Rejection (CMR) in Renal Transplant Patients
N. Raj, S. Jackson, S. Riad, R. Spong, V. Vakil, A. Matas, D. Keys
University of Minnesota, Minneapolis, MN
*Purpose: Prior studies have shown that after treatment of CMR, lack of return to baseline creatinine (Cr.) is associated with increased graft loss. We sought…