Am J Transplant, Volume 19, Suppl 3 Archives - Page 192 of 214 - ATC Abstracts

2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2019 American Transplant Congress
Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis
M. Ni¹, H. Wang¹, D. Jin¹, J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a clinical problem associated with both surgical and non-surgical settings. Innate immune-dominated inflammation drives the pathogenesis of liver…
2019 American Transplant Congress
Exosomes Carry Stress and Damage Specific miRNAs during Peritransplant Period in TPIAT
P. Saravanan¹, M. Kanak¹, S. Vasu², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Innate inflammation and hypoxia during peritransplant period significantly affect survival of islet grafts. Markers that can identify stress and/or damage during this early period…
2019 American Transplant Congress
A Prognostic Model to Identify Deceased Donor Kidney Transplant Recipients at High Risk for Delayed Graft Function
S. Kawakita, J. L. Beaumont, M. J. Everly
Terasaki Research Institute, Los Angeles, CA
*Purpose: We have previously identified pre-transplant risk factors for delayed graft function (DGF) in deceased donor kidney transplant (DDKT) recipients and built a machine learning…
2019 American Transplant Congress
Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis
D. Rychkov¹, T. Sigdel², J. Liberto², M. Sarwal², M. Sirota³
¹ICHS, Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, UCSF, San Francisco, CA, ³ICHS, UCSF, San Francisco, CA
*Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…
2019 American Transplant Congress
RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection
S. Pineda¹, O. Bestard², T. K. Sigdel¹, M. Sirota³, M. Sarwal¹
¹Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, Bellvitge University Hospital, Barcelona, Spain, ³BCHSI, UCSF, San Francisco, CA
*Purpose: The differentiation of histological phenotypes of T cell mediated cellular rejection (TCMR) and humoral or antibody mediated rejection (AMR) of kidney allografts, bears relevance…
2019 American Transplant Congress
Significance of Histopathologic Features for Predicting Progression in Patients with Transplant Glomerulopathy
X. Li, J. Chen, D. Cheng, R. Wang, W. Wang, M. Zhang, F. Xu, J. Wen, Z. Tang
National Clinical Research Center of Kidney Diseases, Nanjing, China
*Purpose: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. We aimed to determine…
2019 American Transplant Congress
Investigating Deceased Donor Kidney Discard Trend – An Opportunity To Expand The Donor Pool
J. A. Shah¹, D. P. Borle¹, K. Koontz², W. Irish¹, K. V. Ravindra¹
¹Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC, ²Carolina Donor Services, Durham, NC
*Purpose: As the number of patients awaiting kidney transplantation increases from year to year, centers must maximize efforts to transplant kidneys procured. One way of…
2019 American Transplant Congress
DR53, You Can’t See Me: A Deceased Donor Tale of Ambiguous Typing
S. Dionne¹, S. Shetty¹, L. Santiago¹, K. Klama²
¹VRL Eurofins, Centennial, CO, ²VRL Eurofins, Philadelphia, PA
*Purpose: Our laboratory performs STAT HLA typing for an OPO using RT-PCR methodology. A 46 year old, male Caucasian deceased donor was worked up by…
2019 American Transplant Congress
Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations within Ninety Days of Renal Transplant
S. Patel, K. Khalil, A. Lichvar, E. Benedetti, P. West-Thielke
University of Illinois Hospital and Health Sciences System, Chicago, IL
*Purpose: Optimizing tacrolimus (TAC) time within therapeutic range (TTR) has been shown to improve outcomes post-transplant. To date, there are no studies assessing differences in…