Am J Transplant, Volume 19, Suppl 3 Archives - Page 187 of 214 - ATC Abstracts

2019 American Transplant Congress
The Therapeutic Potential of Ex Vivo Induced Monocytic Myeloid-Derived Suppressor Cells from Bone Marrow in a Mouse Cardiac Allotransplantation Model
K. Uchida, K. Fujimoto, E. Yin, H. Bashuda, K. Okumura, K. Takeda
Juntendo University Atopy Research Center, Tokyo, Japan
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that have the ability to cause immunosuppression. In recent years, MDSCs have attracted attention as a…
2019 American Transplant Congress
Organ Transportation by Drone: Surgeon Perspectives
T. Talaie¹, R. Barth², J. R. Scalea¹
¹University of Maryland, Baltimore, MD, ²Surgery, University of Maryland, Baltimore, MD
*Purpose: We recently reported on the first transport of a human kidney using a drone. Ahead of large scale adoption of such a technology, understanding…
2019 American Transplant Congress
Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells
C. Yang¹, J. Ge¹, P. S. Russell¹, J. C. Madsen¹, A. Alessandrini¹, R. B. Colvin²
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
J. H. Voss¹, F. Zheng¹, M. D. Jendrisak², J. R. Leventhal¹, Z. J. Zhang¹, J. M. Mathew¹
¹Surgery – Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Gift of Hope Organ & Tissue Donor Network, Itasca, IL
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…
2019 American Transplant Congress
Investigation and Regulation of Induced Anti-Pig Antibody Production in GTKO Pig-to-Cynomolgus Monkey Artery Retransplantation
S. Hurh¹, E. Lee¹, J. Jeong², G. Lee¹, S. Park¹, S. Ahn³, S. Min³, C. Ahn⁴
¹Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Nephrology, Ajou University School of Medicine, Suwon, Korea, Republic of, ³Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Although the recent progress in xenograft survival in pig-to-nonhuman primate heart and kidney transplantation, little is known about retransplantation in pig antigen-sensitized recipient. This…
2019 American Transplant Congress
Room for Optimism; Improvement in Long-Term Patient and Graft Survival of Kidney Transplants in the United States over the past Three Decades
C. Wu, A. Rana, N. Galvan, C. O'Mahony, J. Goss, B. Murthy
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
*Purpose: Previous studies indicated that the short-term (1 year) allograft survival of kidney transplants has improved significantly over the years. However, less is known about…
2019 American Transplant Congress
Significant Increase in Moderate to High KDPI Kidney Transplants Using a Multi-Operational Approach: Results from the COIIN (Collaborative Innovation and Improvement Network) Initiative
T. Pesavento¹, J. Foutz², K. Sisaithong², D. Klassen², L. Stillion¹, A. Rajab¹, R. Pelletier³, K. Washburn¹, H. Tosoc-Haskell²
¹Ohio State University, Columbus, OH, ²UNOS, Richmond, VA, ³Robert Wood Johnson, New Brunswick, NJ
*Purpose: Kidney transplant (KTx) utilization of moderate to high KDPI (MH-KDPI) deceased donor kidneys remains an opportunity to reduce organ discards. We participated in COIIN,…
2019 American Transplant Congress
Early Use of Everolimus Plus Reduced Tacrolimus vs Standard Tacrolimus in De Novo Livertransplant Recipients: 12 Months Efficacy and Safety Data from HEPHAISTOS Study
B. Nashan¹, P. Schemmer¹, H. Schlitt¹, A. Pascher¹, C. Klein¹, U. Neumann¹, I. Kroeger², P. Wimmer², F. Braun¹
¹Study Group, Hephaistos, Germany, ²Novartis Pharma GmbH, Nuernberg, Germany
*Purpose: The HEPHAISTOS study was set up to compare early use of everolimus [EVR] combined with reduced tacrolimus [rTAC] versus standard-dose tacrolimus [TAC-C) in de…
2019 American Transplant Congress
Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation
K. Louis¹, C. Macedo¹, M. Marrari¹, B. Ramaswami¹, M. Lucas¹, B. Elinoff¹, M. Yamada¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm Unité mixte de recherche 1160, Paris, France
*Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
2019 American Transplant Congress
Cytomegalovirus (CMV) Infection Induces an Angiogenic Response through Hepatic Stellate Cells (HSCs) and Leads to Early Post-Transplant Liver Fibrosis (LF) and Poor Graft Survival
B. H. Ozdemir¹, G. Ozgun¹, E. H. Ayvazoglu Soy², N. Haberal¹, G. Moray², M. Haberal²
¹Pathology, Baskent University, Ankara, Turkey, ²Transplantation, Baskent University, Ankara, Turkey
*Purpose: The ability of the CMV to infect the endothelial cells (ECs) is critical. CMV can increase EC adhesion, permeability, and create a pro-inflammatory environment…