Am J Transplant, Volume 19, Suppl 3 Archives - Page 18 of 214 - ATC Abstracts

2019 American Transplant Congress
miR-20a Inhibits Autophagy by Targeting AKT and BIM in Renal Reperfusion Injury
T. Lin, T. Song, Y. Jiang, J. Liu, Z. Wang, L. Li, Z. Huang, Y. Fan, X. Wang
Organ Transplantation Center, Urology Department, Urology Research Institute, WestChina Hospital, Sichuan University, Chengdu, China
*Purpose: Previously, we found up-regulation of miR-20a after kidney ischemia reperfusion (I/R) injury and may serves as a protector; however, its specific mechanism remains unclear.Autophagy…
2019 American Transplant Congress
Racial and Income-Based Disparities in Access to Kidney Transplantation in the Context of a Nationally-Financed Health System in Brazil
A. Saha¹, G. Ferreira², Y. Yu¹, M. Waldram¹, V. Colares², J. Bastos², M. Henderson¹, D. Segev¹, A. Massie¹
¹Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Changes in economic and social factors in low- and middle-income countries have led to rising burden of chronic disease. Brazil, a middle-income country with…
2019 American Transplant Congress
T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection
R. Reindl-Schwaighofer¹, J. Vetter², J. Weinberger³, S. Schaller², A. Heinzel¹, G. Gualdoni¹, C. Aschauer¹, K. Jelencsics¹, K. Hu¹, S. Winkler², R. Oberbauer¹
¹Nephrology, Medical University of Vienna, Vienna, Austria, ²University of Applied Sciences Upper Austria, Hagenberg, Austria, ³Austrian Red Cross, Vienna, Austria
*Purpose: Tissue infiltration of T-cells is the hallmark of acute cellular graft rejection. Next generation sequencing of T-cell receptors enables in depth analysis of the…
2019 American Transplant Congress
BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival
J. Zhang, Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: The present study aimed to investigate the role of BTLA in the progress of acute rejection after kidney transplantation.*Methods: In human allograft renal transplanted…
2019 American Transplant Congress
Differential Expression of B Cell Activating Factor in Experimental Models of Acute and Chronic Active Antibody-Mediated Rejection
S. Reese, N. Wilson, L. Ptak, R. Redfield, A. Djamali, S. E. Panzer
University of Wisconsin Madison, Madison, WI
*Purpose: The B cell survival cytokine, BAFF [B cell activating factor], promotes B cell maturation and is a marker of disease activity in a variety…
2019 American Transplant Congress
AMD3100 and Low-Dose FK506 Prevent De Novo Donor Specific Antibody Formation and Rejection in a Sensitized Kidney Transplantation Model
A. R. Ahmadi, L. Qi, R. N. Wesson, A. M. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: De novo donor specific antibody (DSA) formation and antibody mediated rejection (AMR) are the main cause of allograft failure long-term. We have developed a…
2019 American Transplant Congress
The Innsbruck Handtransplant Program: Eighteen Years of Experience
F. Messner, T. Hautz, A. Weissenbacher, S. Schneeberger
Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
*Purpose: Reconstructive transplantation represents a therapeutic option for severe tissue defects which are not amendable to conventional reconstructive attempts. We herein report long-term follow-up data…
2019 American Transplant Congress
Mitochondrial Permeability Regulates Heart Graft Ischemia – Reperfusion Injury and Rejection
A. Qamar¹, J. Jiang¹, X. Huang², P. McLeod², A. M. Jevnikar², Z. Zhang²
¹Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada
*Purpose: A growing body of evidence indicates that mitochondrial permeability transition pore (mPTP) formation plays a crucial role in necroptosis - a programmed form of…
2019 American Transplant Congress
Flow Cytometric Analysis of Leukocyte Migration during Ex Vivo Lung Perfusion with CXCR4 Inhibition
J. Yerxa¹, Q. Gao¹, R. P. Davis², M. Zhang¹, U. Scheuermann¹, W. Parker¹, M. G. Hartwig², A. Barbas¹
¹General Surgery, Duke University, Durham, NC, ²Thoracic Surgery, Duke University, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a preservation technique utilized to evaluate candidate donor lungs in a metabolically active state. This also…
2019 American Transplant Congress
Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study
M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴
¹Transplantation, Baskent University, Ankara, Turkey, ²Pharmacology, Baskent University, Ankara, Turkey, ³Pathology, Baskent University, Ankara, Turkey, ⁴Experimental Laboratory, Baskent University, Ankara, Turkey
*Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…