Am J Transplant, Volume 19, Suppl 3 Archives - Page 18 of 214 - ATC Abstracts

2019 American Transplant Congress
Differences of Gut Microbiota Composition between Donor and Recipient May Predict 1-Year Graft Function
J. Kim¹, H. Cho², J. Park³, J. Jeong¹, M. Kwak⁴, B. Kim⁴, D. Kim¹, J. Lee⁵, B. Kim⁶, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Chungbuk National University Hospital, Cheongju, Korea, Republic of, ³Kangwon National University Hospital, Seoul, Korea, Republic of, ⁴Chunlab Inc., Seoul, Korea, Republic of, ⁵Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Signals derived from gut microbiota are critical for the development and maintenance of the human immune system. In view of kidney transplantation (KT), allograft…
2019 American Transplant Congress
Using an Electronic Medical Record Tool to Document Transplant Option Discussions among Patients with EGFR ≤ 20 mL/min/1.73m²
A. Yishak¹, R. R. Brentari², R. M. Love La Londe³, E. Clark⁴, E. Clark⁴, J. Sun⁵, S. Vupputuri⁶
¹Nephrology, MAPMG, Mc Lean, VA, ²KP National Transplant Service, Oakland, CA, ³KP National Transplant Services, Oakland, CA, ⁴KP National Transplant Services, silver spring, MD, ⁵KP, Rockville, MD, ⁶MAPRI, MAPMG, Rockville, MD
*Purpose: The purpose of this study, in a large integrated health system, was to improve: 1) the documentation of transplant option discussions by providers among…
2019 American Transplant Congress
CNI-Free Therapy with Iscalimab (anti-CD40 mAb) Preserves Allograft Histology Compared to Standard of Care after Kidney Transplantation
E. Farkash¹, A. Naik¹, H. Tedesco-Silva², B. Nashan³, O. Witzke⁴, M. van den Hoogen⁵, S. Berger⁶, D. M. Cibrik⁷, S. Mulgaonkar⁸, D. B. Leeser⁹, R. Alloway¹⁰, A. Patel¹¹, J. Pratchke¹², C. Sommerer¹³, A. Wiseman¹⁴, A. Van Zuilen¹⁵, U. Laessing¹⁶, J. Rush¹⁶, B. Haraldsson¹⁶
¹Univ of Michigan, Ann Arbor, MI, ²Hospital do Rim, São Paulo, Brazil, ³Univ. Hamburg, Hamburg, Germany, ⁴Univ Essen, Essen, Germany, ⁵Erasmus MC, Rotterdam, Netherlands, ⁶UMC Groningen, Gröningen, Netherlands, ⁷Univ of Kansas, Kansas City, KS, ⁸Saint Barnabas MC, Livingston, NJ, ⁹East Carolina Univ, Greenville, NC, ¹⁰Univ of Cincinnati, Cincinnati, OH, ¹¹Henry Ford Hosp, Detroit, MI, ¹²Charité Univ, Berlin, Germany, ¹³Univ Heidelberg, Heidelberg, Germany, ¹⁴Univ of Colorado SM, Denver, CO, ¹⁵Univ MC, Utrecht, Netherlands, ¹⁶Novartis, Basel, Switzerland
*Purpose: To assess if calcineurin (CNI)-free therapy with iscalimab preserves the quality of transplanted kidney grafts.*Methods: Iscalimab (CFZ533) is a new, fully human, Fc-silenced, non-depleting,…
2019 American Transplant Congress
Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection
A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal
Department of Surgery, UCSF, San Francisco, CA
*Purpose: Multiplexed droplet single-cell RNA-sequencing (mdscRNA-seq) has been utilized across many tissue types for fast and paralleled transcriptomic profiling. However, maintaining sample identity for differential…
2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
Iguratimod Attenuates the Production of Donor Specific Antibody by Inducing CD19⁺Tim-1⁺ Regulatory B Cells and Imbalance of Th17 Treg
Z. Wang, S. Fei, H. Chen, Z. Han, L. Sun, J. Tao, X. Ju, M. Zheng, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: This study was designed to investigate the effect and mechanisms of Iguratimod on circulating DSA and allograft survival in a skin transplant model.*Methods: Mice…
2019 American Transplant Congress
Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients
T. J. Borges¹, J. T. O’Malley², B. Kollar³, B. Pomahac³, S. G. Talbot³, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Plastic Surgery, Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…
2019 American Transplant Congress
Heterozygous Gene Mutations In The Complement Factor I (cfi) Was Susceptibility Gene For The C3 Glomerulonephritis In Native Kidney And Renal Allograft
J. Wen, H. Song, X. Ni, M. Zhang, F. Xu, X. Zhu
Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, Jiangsu, China
*Purpose: We previously reported heterozygous c.848A > G and c.1339C > T gene mutations in the complement factor I (CFI) gene (NM_000204.3) in a kidney transplant recipient with C3…
2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…
2019 American Transplant Congress
Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury
Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…