Am J Transplant, Volume 19, Suppl 3 Archives - Page 165 of 214 - ATC Abstracts

2019 American Transplant Congress
APRIL^-/-/BLyS^-/-Deplete Antibody Secreting Cells and Alloantibody Production in Sensitized Antibody Mediated Rejection Model
N. Bath, B. Verhoven, N. Wilson, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A proliferation inducing ligand) and BLyS (B Lymphocyte Stimulator) are two…
2019 American Transplant Congress
CD19⁺Tim-1⁺ Regulatory B Cells Mediate the Balance of Th17 Treg to Decrease the Level of Donor-Specific Antibodies in Mice Secondary Skin Transplantation Model
Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: In this study, we were aimed to explore the potential influence of CD19+Tim-1+ Regulatory B cells (Bregs) on the production of DSAs in a…
2019 American Transplant Congress
The Scope and Limitations of Current Public Education Materials on Vascular Composite Allotransplantation and Donation in the United States
M. Henderson¹, S. Rasmussen¹, J. Uriarte², N. Anderson², B. Doby¹, C. Cooney¹, G. Brandacher¹, D. Segev¹, E. Gordon²
¹Johns Hopkins University, Baltimore, MD, ²Northwestern University, Chicago, IL
*Purpose: As the field of Vascular Composite Allotransplantation (VCA) evolves and more VCAs are performed, the demand for VCA donations will increase. However, the public…
2019 American Transplant Congress
Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage
J. Lion¹, K. Poussin¹, E. Chong², D. Glotz³, N. A. Mooney¹
¹Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, ²Vitaeris, Vancouver, BC, Canada, ³Nephrology and Transplantation, Hôpital Saint Louis, Paris, France
*Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
2019 American Transplant Congress
Novel Molecular Mechanisms Associated with Normothermic Ex-Vivo Kidney Perfusion
C. McEvoy¹, T. Tokar², S. Reid³, P. Urbanellis³, M. Hamar¹, M. Kaths¹, I. Jurisica², L. Robinson⁴, M. Selzner¹, A. Konvalinka¹
¹MOT Programme, University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, UHN, Toronto, ON, Canada, ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Sick Kids Research Institute, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is associated with significantly improved graft function following transplantation in comparison to static cold storage (SCS), however the molecular…
2019 American Transplant Congress
Withaferin A as a Possible Therapy for Chronic Allograft Nephropathy
T. Divanyan¹, D. Patel¹, E. Acosta¹, D. Howard², F. Jourd'heuil², D. Jourd'heuil², R. Lopez-Soler³
¹Albany Medical College, Albany, NY, ²Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ³Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: One of the possible steps in the development of post-transplant interstitial fibrosis is epithelial to mesenchymal transition (EMT) of proximal renal tubular cells with…
2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
Urine Uromodulin Associates with Deceased Donor Acute Kidney Injury and Allograft Failure
S. G. Mansour¹, I. Hall², P. Reese³, T. Ashkar⁴, Y. Jia⁴, H. Thiessen-Philbrook⁴, M. Doshi⁵, C. R. Parikh⁴
¹Yale, New Haven, CT, ²University of Utah, Salt Lake City, UT, ³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁴Johns Hopkins University, Baltimore, MD, ⁵University of Michigan, Ann Arbor, MI
*Purpose: Produced exclusively by renal epithelial cells of the thick ascending limb, Uromodulin (UMOD, also known as Tamm-Horsfall protein) is the major component of hyaline…
2019 American Transplant Congress
Evidence to Support the Use of Kidney Allograft Function as a Clinical Trial Outcome Measure
M. Kadatz, J. Gill, S. Clark, J. S. Gill
Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: As a biomarker, kidney allograft function has been rejected as clinical trial outcome measure because it is not predictive of allograft survival. In this…