Am J Transplant, Volume 19, Suppl 3 Archives - Page 165 of 214 - ATC Abstracts

2019 American Transplant Congress
Functional Characterization of Orthotopic Hind-Limb Transplants in Rats
F. Zheng, X. Zhang, L. Qiu, J. Wang, X. Yeap, K. M. Koss, J. Wertheim, Z. J. Zhang
Comprehensive Transplant Center and Department of Surgery, Northwestern University, Chicago, IL
*Purpose: Vascularized composite allotransplantation (VCA) is a valid therapeutic option for patients with non-salvageable injuries such as severe burns or limb amputation. The immune response…
2019 American Transplant Congress
Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy
H. Choi¹, Y. Kim², M. Kim², K. Jun², S. Kim², S. Park³, J. Kim⁴, I. Moon⁵, J. Hwang⁶
¹Clinical Research Center, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of, ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Transplant Surgery, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ⁴Transplant Surgery, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of, ⁵Transplant Surgery, Yeouido St. Mary's Hospital, Seoul, Korea, Republic of, ⁶Transplant Surgery, Daejeon St. Mary's Hospital, Daejeon, Korea, Republic of
*Purpose: Ischemic preconditioning (IPC), which is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion (I/R) through the up-regulation of endogenous protective…
2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
2019 American Transplant Congress
Withaferin A Shifts Circulating Lymphocytes toward Protective T Cell Subsets and Prolongs Islet Allograft Survival in a Mouse Transplant Model
K. Kumano¹, M. Kanak², C. Darden³, S. Vasu¹, Y. Liu⁴, M. C. Lawrence¹, B. Naziruddin⁴
¹Baylor Scott and White Research Institute, Dallas, TX, ²Department of Surgery, Virginia Commonwealth University, Richmond, VA, ³Institute of Biomedical Studies, Baylor University, Waco, TX, ⁴Baylor Simmons Transplant Institute, Dallas, TX
*Purpose: : Immunosuppression protocols improve the efficacy of allogeneic islet transplantation. However, decline in islet graft function and toxicities imposed by current immunosuppressant drugs remain…
2019 American Transplant Congress
External Validation of Donor-Derived Cell-Free DNA to Detect Rejection in Kidney Transplant Recipients
E. Huang, S. Sethi, A. Peng, R. Najjar, A. Vo, S. Jordan
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA; Allosure®, CareDx) became Medicare-reimbursable in the United States in October, 2017 for the detection of rejection in kidney transplant recipients…
2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
2019 American Transplant Congress
Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial
R. Heilman¹, D. Taber², K. Guo³, S. Brietigam³, j. charette³, S. Kurian⁴, M. Abecassis³, J. Friedewald³
¹Mayo Clinic AZ, Scottsdale, AZ, ²MUSC, Charleston, SC, ³Northwestern University, Chicago, IL, ⁴Scripps, La Jolla, CA
*Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹
¹RIMUHC, Montreal, QC, Canada, ²SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…
2019 American Transplant Congress
Change in Estimated Glomerular Filtration Rate and Risk of Allograft Failure in Patients Diagnosed with Active Antibody-Mediated Rejection Following Kidney Transplantation
W. Irish¹, P. Nickerson², B. Astor³, E. Chong⁴, C. Wiebe², F. Moreso⁵, D. Seron⁵, M. Crespo⁵, L. Gache⁶, A. Djamali³
¹East Carolina University, Greenville, NC, ²University of Manitoba, Winnipeg, MB, Canada, ³University of Wisconsin, Madison, WI, ⁴Vitaeris, Inc, Vancouver, BC, Canada, ⁵University Hospital Vall d'Hebron, Barcelona, Spain, ⁶CTI Clinical Trial & Consulting, Covington, KY
*Purpose: There are challenges in designing an adequate and well-controlled study of patients with active antibody-mediated rejection (ABMR), especially in the absence of a valid…
2019 American Transplant Congress
Donor And Recipient Age Matching Versus Mismatching In Expanded Criteria Donor Kidney Transplants: Does It Make A Difference?
D. Harriman, V. Gurram, A. Farney, J. Rogers, G. Orlando, C. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta
Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: The critical shortage of donor organs challenges the transplant community to optimize the use of organs from all consented deceased donors (DD). The purpose…