Am J Transplant, Volume 19, Suppl 3 Archives - Page 165 of 214 - ATC Abstracts

2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
D. T. Tran, C. Atkinson, S. N. Nadig
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
2019 American Transplant Congress
Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation
S. Kanangat¹, I. Kurbegovic-Skaljic², D. Cimbaluk², M. Oppermann², S. Jensik³, E. Hollinger³, O. Olaitan⁴, R. DeCresce²
¹Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, ²Pathology, Rush University Medical Center, Chicago, IL, ³Surgery, Rush University Medical Center, Chicago, IL, ⁴Tumor Immunology, Rush University Medical Center, Chicago, IL
*Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
2019 American Transplant Congress
Uterus Transplantation: Recipient Surgery
L. Johannesson, A. Wall, J. Bayer, G. J. McKenna, G. Testa
Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
*Purpose: The field of uterus transplantation, since the first birth to a uterus transplanted woman in 2014, continues to grow rapidly. As of today at…
2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
R. Novotny¹, J. Chlupac¹, R. Matejka², T. Marada¹, P. Mericka³, L. Sterba³, L. Janousek¹, J. Fronek¹
¹Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ³Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Islet Stress Leads to Increased Release of Exosomes That Stimulate Immune Cell Response
S. Vasu¹, C. Darden², K. Kumano¹, B. Naziruddin³, M. Lawrence³
¹Baylor Scott and White Research Institute, Dallas, TX, ²Institute of Biomedical Studies, Baylor University, Waco, TX, ³Baylor University Medical Ctr, Dallas, TX
*Purpose: Islet dysfunction and death caused by isolation procedures, immune attack and hypoxia significantly affect islet transplantation outcomes. Non-invasive monitoring of islet stress and damage…
2019 American Transplant Congress
Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support
M. Wong¹, R. Narra², M. Selim¹, M. A. Zimmerman¹, A. Padmanabhan³, J. C. Hong¹
¹Div. of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI, ²Div. of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, ³Medical College of Wisconsin and BloodCenter of Wisconsin, Milwaukee, WI
*Purpose: Liver transplantation is a high platelet transfusion (PLT) setting due to the elevated incidence of thrombocytopenia and bleeding. HLA-I antibodies are thought to have…
2019 American Transplant Congress
Elevated Urinary Injury Biomarkers in Deceased Donors Are Not Associated with Long-Term Kidney Transplant Outcomes
N. Koyawala, I. E. Hall, Y. Jia, S. G. Mansour, P. P. Reese, H. R. Thiessen-Philbrook, E. Akalin, J. S. Bromberg, M. D. Doshi, M. N. Harhay, S. Mohan, T. Muthukumar, B. Schroppel, P. Singh, F. L. Weng, C. R. Parikh
DDS Consortium, Baltimore, MD
*Purpose: In the United States, over 90,000 people are on the kidney transplant waiting list and could benefit from more donor organs. Kidneys from deceased-donors…
2019 American Transplant Congress
Using Multidimensional Quality of Life Measurement to Better Understand the Benefit of Living Donor Kidney Transplant
J. Peipert, J. Caicedo-Ramirez, K. Ensor, J. Friedewald, M. Abecassis, D. Cella, Z. Butt, D. Ladner
Northwestern University, Chicago, IL
*Purpose: Patient and graft survival after living donor kidney transplant (LDKT) are generally excellent, but there remains some variation in health-related quality of life (HRQOL)…