Am J Transplant, Volume 19, Suppl 3 Archives - Page 145 of 214 - ATC Abstracts

2019 American Transplant Congress
Impact Of Delayed Kidney Transplantation On Positive Crossmatch Liver Kidney Transplantation
Z. Rokop, C. Kubal, B. Ekser, R. Mangus, J. Fridell, P. Mihaylov, W. Goggins
Department of Surgery, Indiana University Hospital, Indianapolis, IN
*Purpose: Kidney transplantation in sensitized patients is associated with an increased immunological risk. Significant decrease in circulating anti-HLA donor specific antibodies (DSA) has been observed…
2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
J. Attard¹, W. Dunn², L. Wallace¹, R. Laing¹, Y. Boteon¹, H. Mergental³, D. Mirza³, T. Perera³, S. Afford¹
¹CLGR, University of Birmingham and NIHR Biomedical Research Centre, Birmingham, United Kingdom, ²Phenome Centre Birmingham, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…
2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
S. Lee, S. Noel, J. Kurzhagen, M. Sadasivam, A. Hamad, H. Rabb
Johns Hopkins, Baltimore, MD
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…
2019 American Transplant Congress
Upregulation of Endothelial HLA Class II as a Marker of Antibody Mediated Rejection in Heart Allograft Biopsies
Q. Cai, Y. Butt, A. Hendricks, J. Torrealba
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: In 2013, the ISHLT (International Society of Heart and Lung Transplant) introduced the working classification for pathological changes associated with antibody-mediated rejection of the…
2019 American Transplant Congress
What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers
P. West-Thielke¹, A. Maldonado², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, D. Brennan⁴
¹University of Illinois, Chicago, Chicago, IL, ²Vidant Medical Center, Greenville, NC, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
2019 American Transplant Congress
Recipient Outcomes Following Transplantation Of Allografts From Older Live Kidney Donors With Hypertension
F. Al Ammary¹, S. Yu², A. D. Muzaale³, D. C. Brennan⁴, A. C. Wiseman⁵, D. L. Segev³, A. B. Massie³
¹Johns Hopkins Medicine, Greenbelt, MD, ²Johns Hopkins Medicine, Baltimore, MD, ³Surgery, Johns Hopkins Medicine, Baltimore, MD, ⁴Medicine, Johns Hopkins Medicine, Baltimore, MD, ⁵Medicine, University of Colorado, Aurora, CO
*Purpose: Healthy older live kidney donor candidates with hypertension may provide an opportunity to increase live kidney donation. However, the impact of this practice on…
2019 American Transplant Congress
Ready for Prime Time: Intentional Allocation of Hepatitis C Positive Livers into Hepatitis C Negative Recipients
P. N. Martins¹, B. Movahedi¹, D. Devuni², P. Mahboub¹, A. Bozorgzadeh¹
¹Surgery, Division of Transplantation, University of Massachusets, Worcester, MA, ²Medicine, Division of Hepatology, University of Massachusets, Worcester, MA
*Purpose: The current discrepancy between supply and demand of liver grafts has dramatically increased the waiting time and mortality on the waiting list. The recent…
2019 American Transplant Congress
Erythropoietin Ameliorates Parent to F1 Murine Graft versus Host Disease by Inhibiting T_FH
A. Angeletti¹, C. Donadei¹, A. Cumpelik¹, C. Cantarelli¹, C. Guglielmo¹, G. La Manna², P. Heeger¹, P. Cravedi¹
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (DIMES), Policlinico Sant'Orsola-Malpighi, Bologna, Italy
*Purpose: Building upon our previously generated evidence that erythropoietin (EPO) directly inhibits effector T cells (JASN 2015, 2017) and reduces autoantibody formation in murine lupus,…
2019 American Transplant Congress
Evaluation of Influenza Virus Antibody Response in Naturally Infected and Vaccinated Transplant Recipients by Protein Microarray
C. Hirzel, A. Chruscinski, V. H. Ferreira, A. G. L'Huillier, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Influenza A virus (IAV) infection is known to be an important cause of morbidity in solid organ transplant (SOT) recipients. The objective of our…
2019 American Transplant Congress
Lung Transplant Outcomes after CABG
S. Huddleston¹, R. Aggarwal¹, S. Jackson², N. Lemke¹
¹Surgery, University of Minnesota, Minneapolis, MN, ²Surgery, Fairview Health Services, Minneapolis, MN
*Purpose: Prior coronary artery bypass grafting (CABG) has been a contraindication to lung transplantation (LTx) due to increased mortality associated with bilateral lung transplant. We…