ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Microscopic Hepatic Steatosis Prior to Liver Transplantation Influences Clinical Outcomes

    K. Nakamura, H. Hirao, T. Ito, S. Kageyama, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Liver Transplant, UCLA, Los Angeles, CA

    *Purpose: Although liver transplantation (LT) has become a standard care for end-stage liver diseases, early allograft dysfunction (EAD) and rejection crises curtail the outcomes. Considering…
  • 2019 American Transplant Congress

    Anti- CD154 / CD40 Costimulation Blockade is Superior to Tacrolimus in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation

    B. P. Lovasik1, A. J. Matar1, C. Breeden1, J. Jenkins2, J. Tector3, S. C. Kim1, A. B. Adams1

    1Emory Transplant Center, Emory University, Atlanta, GA, 2Yerkes National Primate Center, Emory University, Atlanta, GA, 3University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Costimulation blockade strategies targeting the CD40/CD154 pathway are highly effective in preventing xenograft rejection in pig-to-nonhuman primate (NHP) transplantation models. The aim of this…
  • 2019 American Transplant Congress

    Association of Pretransplant and Posttransplant 5-Tier Ratings with Candidate Mortality after Listing

    A. Wey, S. Gustafson, N. Salkowski, B. Kasiske, M. Skeans, C. Schaffhausen, A. Israni, J. Snyder

    SRTR, Minneapolis, MN

    *Purpose: The OPTN Final Rule mandates the Scientific Registry of Transplant Recipients (SRTR) to publish understandable reports of transplant rate, waitlist mortality, and posttransplant outcomes.…
  • 2019 American Transplant Congress

    The National Landscape of Heart Transplant Candidates with HIV

    A. A. Shaffer1, A. G. Thomas2, D. L. Segev1

    1Surgery & Epidemiology, Johns Hopkins University, Baltimore, MD, 2Epidemiology, University of North Carolina, Chapel Hill, NC

    *Purpose: Heart disease is a leading cause of death for HIV+ individuals, and the number of HIV+ heart transplant (HT) recipients is growing. Although understanding…
  • 2019 American Transplant Congress

    Using Ensembles of Machine Learning Classifiers to Maximize the Accuracy and Stability of Molecular Biopsy Interpretation

    J. Reeve1, K. S. Madill-Thomsen2, P. F. Halloran and the INTERCOMEX Study Group3

    1University of Alberta, Edmonton, AB, Canada, 2Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, 3University of Alberta, Edmonton AB, AB, Canada

    *Purpose: The Molecular Microscope diagnostic system (MMDx), based on microarray gene expression, uses ensembles of machine learning classifiers rather than single genes, gene sets, or…
  • 2019 American Transplant Congress

    Using a Commercially Available Assay That Measures Cytomegalovirus-Specific CD4+ and CD8+ T-cell Immunity to Predict Clinically Significant Cytomegalovirus Events in Solid Organ Transplant Recipients

    R. Rogers1, K. Saharia2, A. Chandorkar2, Z. Weiss3, D. Farmakiotis1

    1Infectious Diseases, Brown University, Providence, RI, 2Infectious Diseases, University of Maryland, Baltimore, MD, 3Internal Medicine, Brown University, Providence, RI

    *Purpose: To assess the diagnostic performance and clinical utility of the Viracor CMV T-cell Immunity Panel (CMV-TCIP), which measures both CMV-specific Cd4+ and Cd8+ T-cell…
  • 2019 American Transplant Congress

    Capitalizing On Donor Density To Increase Organ Pool – An Analysis Of Urban And Rural Organ Donors

    S. Bakhtiyar, S. Ahmed, J. A. Goss, A. Rana

    Baylor College of Medicine, Houston, TX

    *Purpose: The primary factor limiting access to organ transplantation is the limited supply of deceased donor allografts. While there are multiple potential strategies to increase…
  • 2019 American Transplant Congress

    Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells

    C. Ward1, L. Vo2, E. De Klerk2, G. Faleo2, Y. Kelly1, J. Bluestone2, M. Hebrok2, P. Stock1, Q. Tang1

    1Surgery, UCSF, San Francisco, CA, 2Diabetes Center, UCSF, San Francisco, CA

    *Purpose: Islet transplantation can cure Type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets when removed from their native…
  • 2019 American Transplant Congress

    Intra-abdominal Hypertension And Abdominal Compartment Syndrome: An Organ Procurement Organization’S Experience

    J. Stefek1, L. E. Markham1, M. Ott1, S. S. Johnson2, J. C. Olson3, H. Sangha4, D. G. Vasquez5, S. P. Whitt6, H. E. Wilkins1, P. A. Webster1, M. Iliakova7, M. Moncure7

    1Midwest Transplant Network, Westwood, KS, 2Via Christi St Francis, Wichita, KS, 3University of Kansas Medical Center, Kansas City, KS, 4Lake Regional Health System, Osage Beach, MO, 5Wesley Medical Center, Wichita, KS, 6University of Missouri Health Care, Columbia, MO, 7University of Missouri - Kansas City, Kansas City, MO

    *Purpose: Because of a shortage of available organs, an average of 22 people die each day waiting for a transplant. There has been significant research…
  • 2019 American Transplant Congress

    Intravenous Immunoglobulin Significantly Reduces Bioavailability of Concomitantly Administered Anti-C5 Monoclonal Antibodies

    S. C. Jordan1, K. Kucher2, M. Bagger2, H. Hockey3, K. Wagner4, N. Ammerman1, J. Choi1, A. Vo1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Ctr, Los Angeles, CA, 2Novartis Institutes for BioMedical Research, Basel, Switzerland, 3Biometrics Matters Ltd, Hamilton, New Zealand, 4Novartis Institutes for BioMedical Research, Cambridge, MA

    *Purpose: Awareness of drug-drug interactions is critical in management of organ transplant recipients. However, there is little understanding of the possibility of biologic agents interfering…
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