2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…2019 American Transplant Congress
Technology Triggered Adherence Intervention – Preliminary Findings
1University of Cincinnati, Cincinnati, OH, 2UC Health, Cincinnati, OH
*Purpose: Medication non-adherence (M-NA) after renal transplant (RT) increases the risk of graft failure. We conducted a prospective, randomized, single center trial to evaluate 3…2019 American Transplant Congress
Exogenous Erythropoietin Administration Promotes Murine Cardiac Allograft Survival via a Myeloid Cell-Dependent Mechanism
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Erythropoietin (EPO) ligation of the EPO receptor (EPO-R) homodimer and EPO-R/CD131 heterodimer has protolerogenic effects on alloreactive T cell responses. While prior work, largely…2019 American Transplant Congress
Hard-to-Place Kidney Offers: Through the Lens of the United Network for Organ Sharing Organ Center
United Network for Organ Sharing, Richmond, VA
*Purpose: In 2016, the rate of deceased donor kidney discard continued to increase to 20%. It is well documented that multiple factors contribute to lower…2019 American Transplant Congress
Routine Molecular Clostridioides difficile Screening and Overtreatment in Solid Organ Transplant Recipients
*Purpose: The objective of this analysis is to determine how frequently positive Clostridioides difficile (CD) screening tests, potentially identifying up to 20% of inpatients with…2019 American Transplant Congress
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
*Purpose: FTY720, a S1PR agonist has been shown to protect kidneys from IRI. However, systemic use is limited due to adverse side effects. Dendritic cells…2019 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…2019 American Transplant Congress
Is Kidney Transplantation Actually a Cost-Effective Alternative Also for Older Patients?
*Purpose: We aimed to study the health economic effects of kidney transplantation in a population of kidney transplant candidates > 65 years of age.*Methods: We…2019 American Transplant Congress
Donors and Drugs: How Often Do They Mix? Utilization of Donors Based on Toxicology Findings
*Purpose: Despite an increasing number of patients waiting for heart transplantation, the growth of transplant volume has risen slowly. The opioid crisis has resulted in…2019 American Transplant Congress
Comparative Analysis of Belatacept and Mycophenolate Monotherapy-Based Regimens for HLA Identical Living Donor Kidney Transplantation
Univ. of Cincinnati, Cincinnati, OH
*Purpose: HLA identical (HLA ID) living donor kidney transplants (KTx) provide long-term survival with substantially reduced rejection risk; aspects that can be exploited in designing…
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