Am J Transplant, Volume 19, Suppl 3 Archives - Page 119 of 214 - ATC Abstracts

2019 American Transplant Congress
Long Term Cold Ischemia Time in Kidney Transplantation. The Role of Hypothermic Machine Perfusion
G. ADANI¹, U. Baccarani¹, P. Tulissi², C. Vallone², A. Risaliti¹
¹General Surgery and Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy, ²Nephrology, Dialysis and Kidney Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy
*Purpose: Hypothermic machine perfusion (HMP) of deceased donor kidneys is associated with a better outcome than static cold storage (SCS). Aim of this prospective study…
2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
A. Longchamp¹, R. P. Meier², N. Colucci³, A. Balaphas³, L. Orci³, A. Nastasi³, G. Longchamp¹, S. Moll⁴, A. Klauser⁵, F. Lazeyras⁵, M. Pascual⁶, J. Corpataux⁷, L. Bühler⁸
¹Department of Vascular Surgery, CHUV, Lausannne, Switzerland, ²Department of Surgery, University of California San Francisco, San Francisco, CA, ³Department of Surgery, HUG, Geneva, Switzerland, ⁴Department of Pathology, HUG, Geneva, Switzerland, ⁵Department of Radiology, HUG, Geneva, Switzerland, ⁶Department of Transplantation, CHUV, Lausannne, Switzerland, ⁷Department of Vascular Surgery, CHUV, Lausanne, Switzerland, ⁸Department of Surgery, CHUV, Lausannne, Switzerland
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial Outcomes: Proteomic Analysis of Perfusates from Livers Undergoing Normothermic Machine Liver Perfusion Reveals Biomarkers Predictive of Graft Viability and Post-Transplant Complications
S. Afford¹, L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza⁴, H. Mergental⁵
¹Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ²The School of Biosciences Proteomics Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom, ⁴Liver Unit, The Queen Elizabeth University Hospital, Birmingham, United Kingdom, ⁵The Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom
*Purpose: The VITTAL clinical trial demonstrated that post-ischaemic normothermic machine perfusion(NMP) can increase utilisation of livers from the marginal pool of extended criteria donors (ECD).…
2019 American Transplant Congress
ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
2019 American Transplant Congress
Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome
M. Meneghini¹, E. Crespo², M. Niemann³, A. Torija², E. Melilli⁴, M. Jarque², N. Montero⁴, J. Cruzado¹, J. Grinyo¹, O. Bestard¹
¹Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ³PIRCHE AG, Berlin, Germany, ⁴Kidney Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: PIRCHE-II algorithm predicts mismatched donor-derived HLA peptides number presented on recipient HLAclass-II molecules to recipient T-cells (indirect pathway of allorecognition) and has been associated…
2019 American Transplant Congress
Association between Recipient Sex and Risk of Heart Graft Failure
A. Chackowicz¹, X. Zhang², M. Dahhou², R. Sapir-Pichhadze³, H. Cardinal⁴, B. Foster⁵
¹Faculty of Medicine, McGill University, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Dept. of Medicine, McGill University, Montreal, QC, Canada, ⁴Dept. of Medicine, Université de Montréal, Montreal, QC, Canada, ⁵Dept. of Pediatrics, McGill University, Montreal, QC, Canada
*Purpose: Previous studies of sex differences in heart transplant outcomes focused on interactions between donor and recipient sex, but did not consider the potentially modifying…
2019 American Transplant Congress
Anemia and Hemolysis on Dapsone Despite Normal Glucose-6-Phosphate Dehydrogenase Activity in Heart Transplant Recipients
K. Lor, E. Kransdorf, J. Patel, M. Kittleson, D. Chang, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Dapsone has been considered an acceptable alternative for pneumocystis jirovecii pneumonia (PCP) prophylaxis in sulfa-allergic or -intolerant transplant patients with normal glucose-6-phosphate dehydrogenase (G6PD)…
2019 American Transplant Congress
Cardioprotective Effects of Pre-Operative Cyclosporine in Patients Undergoing Heart Transplantation
Y. Hirase, M. Harris, M. Watson, H. Lee, C. Patel
Duke University Hospital, Durham, NC
*Purpose: The purpose of this study is to determine if pre-operative cyclosporine (Cya) decreases the rate of primary graft dysfunction (PGD) in patients undergoing orthotopic…
2019 American Transplant Congress
Kidney Donor Profile Index Significantly Correlates With Reperfusion Biopsy Findings
A. Perez-Gutierrez¹, P. Witkowski¹, J. Fung¹, D. N. Danz², R. Cummings¹, A. Chang³
¹Transplantation Institute, University of Chicago Medicine, Chicago, IL, ²Economics, University of Pittsburgh, Pittsburgh, PA, ³Pathology, University of Chicago Medicine, Chicago, IL
*Purpose: The kidney donor profile index (KDPI) includes donor factors that are associated with graft survival, and estimates the quality of the kidney graft. Suboptimal…
2019 American Transplant Congress
Renal Allograft Survival after Dual Kidney Transplantation is at Least as Favorable as Outcome after Expanded Criteria Donor Kidney Transplantation
A. Brar¹, M. Sattar¹, A. Gruessner¹, R. M. Jindal², R. Nee³, R. Gruessner¹, M. Salifu¹
¹SUNY Downstate Medical Center, Brooklyn, NY, ²Department of Surgery,, USU-Walter Reed Uniformed Services University, Bethesda, MD, ³USU-Walter Reed Uniformed Services University, Bethesda, MD
*Purpose: Dual kidney transplantation (DKT) is the implantation of two adult kidneys from a marginal donor into a single recipient. DKT may play an important…