Am J Transplant, Volume 19, Suppl 3 Archives - Page 110 of 214 - ATC Abstracts

2019 American Transplant Congress
Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla³, K. Hippen⁴, B. Blazar⁴, S. Schwab⁵
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴U.Minnesota, Minneapolis, MN, ⁵NYU, NY, NY
*Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…
2019 American Transplant Congress
Low Frequency Of Canonical Human Leukocyte Antigen Alloimmunization In Heart Transplantation Candidates With Ventricular Assist Devices
G. K. Mahowald¹, S. L. Saidman¹, G. Lewis², V. Pattanayak¹
¹Pathology, Massachusetts General Hospital, Boston, MA, ²Cardiology, Massachusetts General Hospital, Boston, MA
*Purpose: Screening for anti-HLA antibodies in heart transplantation candidates is complicated by transfusions as well as by the presence of ventricular assist devices (VADs), which…
2019 American Transplant Congress
Early Outcomes Comparing Two Steroid-Avoidance Protocols in Pediatric Renal Transplantation
D. Puliyanda¹, H. Pizzo¹, N. Rodig², M. Somers²
¹Cedars-Sinai Med Ctr, Los Angeles, CA, ²Pediatric Nephrology, Boston Childrens Hospital, Boston, MA
*Purpose: Steroid-avoidance in pediatric kidney transplants (txs) was found effective and safe with daclizumab induction. Upon daclizumab’s discontinuation, lymphocyte-depleting agents became used in this setting,…
2019 American Transplant Congress
Comparison of Two Glucagon-Like-Peptide-1 Analogs (GLP -1) Dulaglutide vs Liraglutide for the Management of Diabetes in Solid Organ Transplant (SOT)
P. Singh, M. Taufeeq, T. E. Pesavento, K. Washburn, D. Walsh, S. Meng
Ohio State University, Columbus, OH
*Purpose: Poorly controlled Type-2 diabetes is an important contributor to graft dysfunction, and cardiovascular morbidity in the SOT. GLP-1-analog has been widely used in the…
2019 American Transplant Congress
Variations in DCD Procurement Procedures across Opos and Their Effects on Liver Transplant Outcomes
A. P. Choubey¹, G. Mitro¹, E. J. Siskind², A. C. Ortiz³, M. Nayebpour⁴, N. Koizumi⁴, P. Wiederhold⁵, J. Ortiz¹
¹The University of Toledo, Toledo, OH, ²Inova Fairfax Hospital, Fairfax, VA, ³University of California, Los Angeles (UCLA), Los Angeles, CA, ⁴George Mason University, Fairfax, VA, ⁵Life Connection Of Ohio, Maumee, OH
*Purpose: Variations in procurement procedures across Organ Procurement Organizations (OPOs) may account for discrepancies in outcomes of donation after cardiac death (DCD) liver transplants. We…
2019 American Transplant Congress
TORC1 Inhibition In Vitro and in a Humanized Mouse Model Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
B. S. Al Dulaijan, S. K. Eskandari, S. Cai, J. Y. Choi, H. Allos, I. Sulkaj, A. Bano, E. Al-Hussein, J. Azzi
Transplantation Research Center, BWH/Harvard Medical School, Boston, MA
*Purpose: Optimizing Regulatory T cells (Tregs) survival is of utmost importance to maximize the efficacy of utilizing them in adoptive cell therapy. We previously described…
2019 American Transplant Congress
Antibody-Suppressor CD8⁺ T Cells Require CXCR5
J. Zimmerer¹, B. A. Ringwald¹, C. L. Avila¹, S. M. Elzein¹, R. T. Warren¹, M. Abdel-Rasoul², G. L. Bumgardner¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…
2019 American Transplant Congress
Opioid and Benzodiazepine Use in Lung Transplant Candidates: A National Survey of Policies and Practices
H. Bruschwein¹, V. Andersen¹, H. Patel², J. Fleming³, A. Shahane¹, M. Weder¹
¹University of Virginia, Charlottesville, VA, ²University of North Carolina, Chapel Hill, NC, ³Medical University of South Carolina, Charleston, SC
*Purpose: The opioid epidemic has raised the question of how transplant teams should work with patients who are prescribed opioids. Benzodiazepine use has also received…
2019 American Transplant Congress
Butyrate-Producing Gut Bacteria and Future Development of Viral Infections in Kidney Transplant Recipients
J. Lee¹, J. Huang¹, M. Magruder¹, L. Zhang¹, M. Lubetzky¹, D. Dadhania¹, E. Edusei¹, E. Pamer², M. Suthanthiran¹
¹Weill Cornell Medicine, New York, NY, ²Memorial Sloan Kettering Cancer Center, New York, NY
*Purpose: Recent studies suggest that the gut microbiome plays a critical role in protecting its host from infections beyond Clostridium difficile. Notably, butyrate-producing bacteria may…
2019 American Transplant Congress
Kidney Transplant Outcomes and Organ Acceptance Practice Patterns: Nationwide Analyses of the US and France
O. Aubert¹, P. P. Reese², Y. Bouatou¹, M. Raynaud¹, C. Legendre¹, D. Glotz¹, C. Lefaucheur¹, C. Jacquelinet³, A. Loupy¹
¹Paris Translational Center for Organ Transplantation, Paris, France, ²Department of Medicine, Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA, ³Agence de la Biomédecine, Paris, France
*Purpose: Approximately 3,500 donated kidneys are discarded in the US each year, drawing concern from Medicare and advocacy groups. We hypothesised that more aggressive organ…