Am J Transplant, Volume 19, Suppl 3 Archives - Page 109 of 214 - ATC Abstracts

2019 American Transplant Congress
Identification Of Pre-transplant Biomarkers Of Recipient Immune Dysfunction That Predict Recipient Risk Of Death Following Liver Transplant: The Immune Frailty Index
K. E. Lunsford¹, N. Aware¹, K. Cleveland¹, C. J. Manner¹, D. T. Nguyen², E. A. Graviss², J. V. Thomas¹, H. Vyas¹, L. W. Moore¹, S. A. Dorman¹, A. Saharia¹, C. M. Mobley¹, M. J. Hobeika¹, X. C. Li¹, R. M. Ghobrial¹
¹Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Houston, TX, ²Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction is well recognized and likely contributes to early mortality following liver transplant (LT) resulting from infections; however, few prior studies have…
2019 American Transplant Congress
A Potential Role for IgE-Mediated Immune Response in the Pathogenesis of Chronic Antibody-Mediated Rejection
F. Rascio¹, P. Pontrelli², G. S. Netti³, E. Manno¹, B. Infante¹, S. Simone², G. Castellano², M. Seveso⁴, E. Cozzi⁴, L. Gesualdo², G. Stallone¹, G. Grandaliano¹
¹Department of Medical and Surgical Sciences, Nephrology Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy, ²Department of Emergency, and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy, ³Dept. of Medical and Surgical Sciences, Clinical Pathology Unit, University of Foggia, Foggia, Italy, ⁴Department of Cardiac, Thoracic and Vascular Sciences, Transplant Immunology Unit, University of Padua, Padova, Italy
*Purpose: Chronic antibody-mediated rejection (CAMR) is the main cause of graft loss and shares with systemic lupus erythematosus (SLE) the antibody-mediated kidney damage and the…
2019 American Transplant Congress
Using Transplant Referral Regions to Measure Access to Kidney Transplant
K. Ross¹, D. Axelrod², R. Patzer¹
¹Emory University, Emory Transplant Center, Atlanta, GA, ²Dept of Surgery, University of Iowa, Iowa City, IA
*Purpose: The transplant community has advocated to emphasize pre-transplant quality metrics to promote access to kidney transplantation (KT). Measuring access to transplant requires a well-defined,…
2019 American Transplant Congress
An International Multicentre Validation Study of the Toronto Listing Criteria for Pediatric Intestinal Transplant
A. J. Roberts¹, P. W. Wales², S. V. Beath³, H. M. Evans¹, J. Hind⁴, T. Wong⁵, D. Mercer⁶, J. Yap⁷, C. Belza⁸, D. Grant⁹, Y. Avitzur¹⁰
¹Department of Paediatric Gastroenterology, Starship Child Health - Auckland District Health Board, Auckland, New Zealand, ²Division of General & Thoracic Surgery, Hospital for Sick Children, University of Toronto,, Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada, ³The Liver Unit, Birmingham Children’s Hospital, Birmingham, United Kingdom, ⁴Paediatric Liver, GI & Nutrition Centre, King's College Hospital, London, United Kingdom, ⁵The Liver Unit, Birmingham Children's Hospital, Birmingham, United Kingdom, ⁶Children’s Hospital and Medical Centre, Omaha, NE, ⁷Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ⁸Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada, ⁹Department of Surgery, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ¹⁰Division of Gastroenterology, Hepatology & Nutrition, Group for Improvement of Intestinal Function and Treatment (GIFT), Transplant Centre, Toronto, ON, Canada
*Purpose: Current intestinal transplantation (IT) listing criteria from 2001 have limited ability to predict the need for IT in the current era of intestinal failure…
2019 American Transplant Congress
The Complexity of T Cell-Mediated Rejection Scenarios: Identifying BK in Biopsies with TCMR
P. F. Halloran and The INTERCOMEX Investigators¹, G. Gupta², J. Reeve³
¹University of Alberta, Edmonton AB, AB, Canada, ²Virginia Commonwealth University, Richmond, VA, ³Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Some transplanted kidneys have concomitant T cell-mediated rejection (TCMR) and BK virus nephropathy (BK). The histologic diagnosis in BK sometimes overlooks the TCMR component,…
2019 American Transplant Congress
Metabolic and Cardiovascular Evaluation in Living Kidney Donors: Survey of US Transplant Centers 2018
N. Garg¹, K. L. Lentine², L. Inker³, A. X. Garg⁴, J. Rodrigue⁵, D. Segeb⁶, D. A. Mandelbrot¹
¹UW Madison, Madison, WI, ²SLU, St. Louis, MO, ³Tufts, Boston, MA, ⁴Western University, London, ON, Canada, ⁵BIDMC, Boston, MA, ⁶JHU, Baltimore, MD
*Purpose: There are very limited data on practice patterns for metabolic and cardiovascular testing of living kidney donor candidates. We surveyed US transplant centers to…
2019 American Transplant Congress
Frailty and BMI in Liver Transplant Candidates: 9-Center Functional Assessment in Liver Transplantation Study
C. Haugen¹, M. McAdams-DeMarco¹, D. Segev¹, E. Verna², R. Rahimi³, M. Kappus⁴, M. Volk⁵, M. Dunn⁶, A. Duarte Rojo⁶, D. Granger⁷, J. O'Leary⁸, D. Ladner⁷, J. Lai⁹
¹JHU, Baltimore, MD, ²Columbia, NYC, NY, ³Baylor, Dallas, TX, ⁴Duke, Durham, NC, ⁵Loma Linda, Loma Linda, CA, ⁶Pitt, Pittsburgh, PA, ⁷Northwestern, Chicago, IL, ⁸DVA, Dallas, TX, ⁹UCSF, San Francisco, CA
*Purpose: Obesity and frailty are associated with an increased risk of waitlist mortality (WLM) in liver transplant (LT) candidates. However, body mass index (BMI) may…
2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal
Department of Surgery, University of Maryland, Baltimore 21201, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
2019 American Transplant Congress
Dialysis Facility Provider Transplant Knowledge after a Randomized Multilevel Intervention to Increase Kidney Transplant Referral and Evaluation in the Southeast
K. Maroney¹, R. Hamoda¹, L. McPherson¹, A. Cruz², S. Pastan¹, L. Plantinga¹, S. Paul¹, M. Ellis³, D. DuBay⁴, A. Reeves-Daniel⁵, R. Detwiler⁶, E. Hartmann⁷, H. Jones⁸, B. Thrasher⁹, C. Zayas¹⁰, L. Mulloy¹⁰, S. Wright¹¹, R. Patzer¹
¹Emory University, Atlanta, GA, ²IPRO Network of the South Atlantic, Raleigh, NC, ³Duke University, Durham, NC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Wake Forest Health Transplant Center, Winston-Salem, NC, ⁶UNC Center for Transplantation, Chapel Hill, NC, ⁷Piedmont Transplant Institute, Atlanta, GA, ⁸Vidant Medical Center Transplant Services, Greenville, NC, ⁹Carolinas Transplant Center, Charlotte, NC, ¹⁰Augusta University, Augusta, GA, ¹¹IPRO Network of the South Atlantic, Morrisville, NC
*Purpose: Dialysis facility provider kidney transplantation (KTx) knowledge influences patient transplant access. The Reducing Disparities in Access to kidNey Transplantation (RaDIANT) Regional Study is a…