ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Role of Innate Allorecognition Pathways in Mouse Renal Allograft Rejection

    D. Zhao1, H. Dai1, K. Abou-Daya1, A. Williams1, M. Oberbarnscheidt1, X. Li2, F. Lakkis1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, 2Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX

    *Purpose: Allograft rejection is initiated by host immune system distinguishing between self and allogeneic non-self (allorecognition). Paired immunoglobulin-like receptor (PIR) and CD47 are molecules expressed…
  • 2019 American Transplant Congress

    Longer-Term Outcomes for Hepatitis C Virus Negative Recipients of Kidneys from Hepatitis C Virus Nucleic Acid Test Positive Donors: The THINKER Trial

    P. Reese1, P. Abt1, E. Blumberg1, R. Bloom1, D. Sawinski1, P. Porrett1, A. Woodards1, K. Reddy1, V. van Deerlin1, R. Hasz2, M. Levine1, R. McLean1, A. Sicilia1, D. Goldberg1

    1University of Penn, Philadelphia, PA, 2Gift of Life, Philadelphia, PA

    *Purpose: Two trials of transplanting hepatitis C virus (HCV) nucleic acid test (NAT) positive kidneys into HCV-negative recipients have been published, both with 100% HCV…
  • 2019 American Transplant Congress

    Robotic-Assisted versus Open Techniques for Living Donor Kidney Transplant Recipients: A Comparison Using Propensity Score Analysis

    F. Tinney, J. Stracke, S. Nagai, L. Malinzak, T. McEvoy, S. Mohamed Ilias, A. Yoshida

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: Following rapid advancements in minimally invasive urology, living donor robotic-assisted kidney transplantation (RAKT) has developed into a feasible alternative to open kidney transplantation (OKT).…
  • 2019 American Transplant Congress

    Lower Rates of Epstein-Barr Virus Viremia and Post-Transplant Lymphoproliferative Disease in Pediatric Solid Organ Transplant Recipients Who Received Valganciclovir Prophylaxis

    E. A. Moulton1, M. Karandikar2, S. Bond3, S. Burchett2, T. Sharma2, F. M. Marty3

    1Baylor College of Medicine, Houston, TX, 2Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    *Purpose: Antiviral prophylaxis to prevent post-transplant lymphoproliferative disease (PTLD) remains controversial, but some data suggest that valganciclovir or ganciclovir use in Epstein-Barr virus (EBV) high-risk…
  • 2019 American Transplant Congress

    Evaluating Liver Regeneration during Normothermic Machine Perfusion in Hepatectomized Rat Liver Model

    M. Aburawi1, S. Mert1, E. Hafiz2, P. Mahboub1, H. Yeh1, K. Uygun1, J. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology and Electron Microscopy, Theodor Bilharz Research Institute, Cairo, Egypt

    *Purpose: Realizing the liver’s unique ability to regenerate, this ongoing study examines Normothermic Machine Perfusion (NMP) as a promising platform for evaluating & potentially simulating…
  • 2019 American Transplant Congress

    PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules

    M. Sadasivam, S. Noel, S. Lee, J. Gong, A. Hamad, H. Rabb

    Johns Hopkins University and School of Medicine, Baltimore, MD

    *Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
  • 2019 American Transplant Congress

    Histologic Ischemia Reperfusion Injury in Liver Transplantation: A Large Single Center Experience

    F. M. Kaldas, T. Ito, S. Younan, J. Aziz, M. Lu, V. G. Agopian, J. DiNorcia III, H. Yersiz, D. G. Farmer, R. W. Busuttil

    Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Ischemia Reperfusion Injury (IRI) is known to adversely affect graft outcomes in Liver Transplantation (LT). Large series examining the significance of IRI found on…
  • 2019 American Transplant Congress

    Prognostic Value of C3d Fixing Preformed Donor-Specific Antibody in Crossmatch-Positive Living Kidney Transplantation

    K. Miyake1, M. Okumi1, Y. Kakuta1, K. Unagami2, M. Furusawa1, H. Ishida2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Sinjuku, Japan, 2Organ Transplant Medicine, Tokyo Women's Medical University, Sinjuku, Japan

    *Purpose: The occurrence of acute antibody-mediated rejection (ABMR) was higher in flow cytometric crossmatch (FCXM)-positive patients despite desensitization, and complement binding ability of donor specific…
  • 2019 American Transplant Congress

    Living Donor Conversion Rates as a Quality Measure for Kidney Program Efficiency for Both New Referrals and Existing Listed Candidates

    E. Woodle1, C. Siemers2, B. Woodle3, C. King2, R. Alloway1, S. Tremblay1

    1U of Cincinnati, Cincinnati, OH, 2UC Health, Cincinnati, OH, 3U of Arkansas, Little Rock, AR

    *Purpose: Arguably the most important achievement for renal failure patients is identification of a living donor (LD)and transplantation with a LD kidney. Given these considerations…
  • 2019 American Transplant Congress

    Prospective Multi-Regional Study of Down-Staging of Hepatocellular Carcinoma to within Milan Criteria before Liver Transplantation

    N. Mehta1, J. Guy2, C. Frenette3, P. Tabrizian4, M. Hoteit5, R. Dhanasekaran6, J. Dodge1, M. L. Holzner4, L. Frankul3, S. Florman4, N. Parikh7, F. Yao1

    1UCSF, San Francisco, CA, 2CPMC, San Francisco, CA, 3Scripps Hospital, La Jolla, CA, 4Mt Sinai, New York, NY, 5U. Pennsylvania, Philadelphia, PA, 6Stanford, Palo Alto, CA, 7U. Michigan, Ann Arbor, MI

    *Purpose: Recent studies from United Network of Organ Sharing (UNOS) Region 5 reported excellent outcomes after liver transplantation (LT) after successful down-staging in HCC patients…
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