Am J Transplant, Volume 19, Suppl 3 Archives - Page 104 of 214 - ATC Abstracts

2019 American Transplant Congress
Regulatory T Cells Combined with Costimulation Blockade Prevent Rejection of Vascularized Composite Allografts
B. Oh¹, G. Furtmüller¹, M. Grzelak¹, L. Vuong², M. Iglesias¹, M. Fryer³, D. Cooney¹, R. Chen⁴, Y. Guo⁵, W. Lee¹, G. Raimondi¹, G. Brandacher¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Washington University in St. Louis School of Medicine, St. Louis, MO, ³The University of Massachusetts Medical School, Worcester, MA, ⁴Kaohsiung Medical Univerity Hospital, Kaohsiung, Taiwan, ⁵Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
*Purpose: Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss. Routine clinical application, however, is hampered by the toxicity of long-term maintenance immunosuppression.…
2019 American Transplant Congress
VCA Deceased Donor Solid Organ Yield
J. Wainright¹, G. Vece¹, C. Wholley², J. Rosendale¹, W. Cherikh¹, C. Curran³, A. Robinson¹, D. Di Battista⁴, D. Klassen⁵
¹Research, UNOS, Richmond, VA, ²Policy and Community Relations, UNOS, Richmond, VA, ³New England Donor Services, Waltham, MA, ⁴Professional Education, UNOS, Richmond, VA, ⁵Office of Chief Medical Officer, UNOS, Richmond, VA
*Purpose: VCA provides life-changing transplants, but the perception exists that VCA procurement complicates the donation process and impedes solid organ donation. This study examined the…
2019 American Transplant Congress
Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death
S. Balaji¹, B. Fuhrmann², D. Lian³, H. Diao³, S. Ma³, Z. Zhang³, A. M. Jevnikar³
¹Physiology, Western University, London, ON, Canada, ²Microbiology and Immunology, Western University, London, ON, Canada, ³London Health Sciences Centre, London, ON, Canada
*Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
2019 American Transplant Congress
Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function
S. Aiello, P. Rodriguez, N. Azzollini, F. Casiraghi, M. Noris, G. Remuzzi, A. Benigni
Mario Negri Institute, Ranica, Italy
*Purpose: Post-transplant (tx) IRI activates TLR/IL-1R on tissue resident leukocytes initiating innate immune response. We studied how donor renal resident macrophages (rMF) respond to post-tx…
2019 American Transplant Congress
Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function
P. West-Thielke¹, J. Oberholzer², Y. Wang³
¹University of Illinois, Chicago, IL, ²University of Virgina, Charlottesville, VA, ³University of Virginia, Charlottesville, VA
*Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…
2019 American Transplant Congress
Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay
A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹
¹Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, ²Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, ³Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada
*Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…
2019 American Transplant Congress
Post-Reperfusion Hepatic Beta-Catenin Activation Regulates Graft Damage, Inflammatory Responses and Transplant Outcomes
H. Hirao, K. Kadono, S. Kageyama, K. Nakamura, T. Ito, J. Aziz, K. J. Dery, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI), an innate-immune driven hepatic inflammation response, represents a major risk factor of early allograft dysfunction (EAD) and rejection in liver…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
2019 American Transplant Congress
‘Back-to-Base’ Normothermic Clinical Liver Perfusion – Cold before NMP Does Not Compromise Protective Benefit
K. Dajani, M. Bral, D. leon Izquierdo, D. Bigam, N. Kneteman, J. Shapiro
University of Alberta Hospital, Edmonton, AB, Canada
*Purpose: In previous clinical studies utilizing normothermic ex situ liver machine preservation, perfusion was initiated rapidly following organ procurement using a portable system transported to…
2019 American Transplant Congress
Impact of Extremely Prolonged Cold Ischemia Time in Combination with AKI on Kidney Transplantation Outcome – A Single Center Experience
N. Sharma, Z. Haddad, Y. Qazi
USC, Los Angeles, CA
*Purpose: Donor kidneys with prolonged cold ischemia time (CIT) and acute kidney injury (AKI) are often rejected on the view they do not achieve successful…