Am J Transplant, Volume 18, Suppl 3 Archives - Page 99 of 211 - ATC Abstracts

2018 American Transplant Congress
Pre-Operative Predictors of Health-Related Quality of Life for Pancreas Transplant Recipients
I. Mosca,³ S. Mittal,¹ J. Smith,² P. Friend.^1,3
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom; ²Nuffield Department of Population Health, Health and Economics Research Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom; ³Oxford Transplant Centre, Oxford University NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom.
A) AimsThe aim of this study is to identify the relative importance of pre-operative recipient and donor factors as possible predictors of post-pancreas transplant health-related…
2018 American Transplant Congress
Three-Month Pancreas Graft Function Significantly Influences Survival Following Simultaneous Pancreas-Kidney Transplantation in Type 2 Diabetes
T. Alhamad,¹ R. Kunjal,¹ A. Malone,¹ D. Brennan,² A. Wiseman,³ J. Wellen,¹ V. Hicks,¹ K. Lentine.⁴
¹Washington University in St. Louis, St. Louis; ²University of Colorado, Denver; ³Johns Hopkins University, Baltimore; ⁴Saint Louis University, St. Louis.
A successful simultaneous pancreas-kidney transplantation (SPK) may improve quality of life, reduce the progression of diabetic complications, and possibly prolong patient and kidney allograft survival…
2018 American Transplant Congress
Improving Organ Donation Rates through a Primary Care Physician Office-Based Intervention
R. Kashyap,¹ M. Dokus,¹ N. Ryan,³ A. James,³ R. Kochik,³ R. Hernandez,¹ J. Dolan,² P. Veazie,² M. Orloff,¹ S. McIntosh.²
¹Surgery, Transplant, University of Rochester Medical Center, Rochester, NY; ²Public Health Sciences, URMC, Rochester, NY; ³Finger Lake Donor Recovery Network, URMC, Rochester, NY.
Background: The inadequate supply of suitable deceased donor organs is well documented. Studies have suggested that Primary Care Providers (PCPs) could help improve donor registration…
2018 American Transplant Congress
Preoperative Patient Education to Improve the Inpatient Experience for Living Donors
K. Ventura, K. Sigafus.
Transplant Department, Hospital of the University of Pennsylvania, Philadelphia, PA.
Purpose: Although the number of living organ donors is small, their altruistic sacrifice requires a dedicated approach to meet their unique needs. Living donors (LD)…
2018 American Transplant Congress
Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells
C. Rickert,^1,2 S. Kimura,^1,2 L. Kojima,¹ K. Lee,¹ M. Aburawi,¹ F. Fontan,¹ K. Deng,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…
2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…
2018 American Transplant Congress
Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…
2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Targeting LTβR Classical NFκB Signaling Facilitates Inflammation Resolution
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, Baltimore.
Background:Contact hypersensitivity (CHS) is a reliable model to assess the immune cell-mediated cutaneous inflammatory response, which includes the three phases of priming/sensitization, elicitation, and resolution,…
2018 American Transplant Congress
Impact of Pre-Transplant Non-Dialysis Renal Dysfunction in Heart Transplant Recipients on Post-Transplant ESRD: A UNOS Database Analysis
S. Akkina, A. Desai, J. Yoo, S. Hou, R. Parasuraman.
Medicine, Loyola University Medical Center, Maywood, IL.
Dialysis prior to heart transplant (HTx) is a strong predictor of patient death and is a common indication for simultaneous heart/kidney transplantation (SHK). The association…