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American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Patient Change in Residence and Risk of Readmission after Renal Transplant in the US

    J. Hogan, M. Anderson, Y. Zhang, J. Kim, G. Karadkhele, X. Zhang, A. Adams, R. Patzer.

    Emory University, Atlanta, GA.

    To predict readmission post-kidney transplant (KTX-R), novel risk factors must be identified. We investigated the impact of a) neighborhood (zipcode) and its attributes and b)…
  • 2018 American Transplant Congress

    Addressing the “Crisis” in Pancreas Transplant Volume Using a Multidisciplinary Approach

    J. Scalea, S. Bartlett, R. Barth.

    Surgery, University of Maryland, Baltimore, MD.

    Background: Due in part to the recently revised pancreas allocation system, patients who are listed for simultaneous pancreas and kidney (SPK) transplantation can be transplanted…
  • 2018 American Transplant Congress

    Evaluation of MPA Dose on Development of DSA Following Pancreas Transplant

    J. Descourouez,1 M. Jorgenson,1 A. Twigg,1 G. Leverson,2 J. Odorico,3 R. Redfield.3

    1Pharmacy, UW Health, Madison, WI; 2Surgery, UW Health, Madison, WI; 3Transplantation, UW Health, Madison, WI.

    The relationship between mycophenolate (MPA) dose and the development of donor specific antibody (DSA) following pancreas transplant has not been elucidated. This study evaluates the…
  • 2018 American Transplant Congress

    Pancreatic Graft Loss after Simultaneous Pancreas Kidney (SPK) Transplant within First 90 Days. Predictors beyond the Surgical Cause. A UNOS/OPTN Data Analysis

    H. Sharma, M. Abraham, J. Chen, D. Mikhail, S. Aquil, S. Patel, A. Skaro, V. McAlister, A. Sener, P. Luke.

    Multi-Organ Transplantation Unit, University of Western Ontario, London, ON, Canada.

    Background: Data on causal effects of variables to predict the early pancreatic graft loss in first 90 days is limited.Aim: To predict the early pancreatic…
  • 2018 American Transplant Congress

    Hospitality Houses and Transplant Patients: Assessing the Impact of a Hospitality House Dedicated to Transplant Patients and Their Families

    T. Giordano,1 J. Campbell,2 J. Weinstock,3 H. Nathan.3

    1Social Work, Gift of Life Family House, Philadelphia, PA; 2Campbell-Collaboratives, LLC, Ardmore, PA; 3Executive Leadership, Gift of Life Donor Program, Philadelphia, PA.

    Hospitality houses exclusively for transplant patients and their families are a relatively new concept and their connection to medical outcomes is untested. One hospitality house…
  • 2018 American Transplant Congress

    ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells

    B. Motyka,1 J. Fersovich,1 B. Lamarche,1 M. Sosniuk,1 I. Adam,1 J. Pearcey,1 K. Tao,1 C. Cairo,2 P. Cowan,3 L. West.1

    1Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; 2Dept Chemistry, University of Alberta, Edmonton, Canada; 3St Vincent's Hospital, Melbourne, Australia.

    Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
  • 2018 American Transplant Congress

    TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival

    L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.

    Path & Lab Med, CHOP & UPenn, Philadelphia, PA.

    Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…
  • 2018 American Transplant Congress

    α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts

    G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…
  • 2018 American Transplant Congress

    Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study

    S. Min,1 T. Papaz,1 T. Blydt-Hansen,3 O. Lee,1 U. Allen,1 P. Birk,2 H. Grasemann,1 L. Hamiwka,4 C. Litalien,5 V. Ng,1 R. Parekh,1 K. Tinckam,6 S. Urschel,7 B. Foster,8 S. Mital.1

    1The Hospital for Sick Children, Toronto, Canada; 2Winnipeg Children's Hospital, Winnipeg, Canada; 3BC Children's Hospital, Vancouver, Canada; 4Alberta Children's Hospital, Calgary, Canada; 5CHU Ste-Justine, Montreal, Canada; 6University Health Network, Toronto, Canada; 7Stollery Children's Hospital, Edmonton, Canada; 8Montreal Children's Hospital, Montreal, Canada.

    PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
  • 2018 American Transplant Congress

    Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease

    M. Sharma, W. Liu, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.

    Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
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