Am J Transplant, Volume 18, Suppl 3 Archives - Page 97 of 211 - ATC Abstracts

2018 American Transplant Congress
Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts
H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Rockefeller University, New York.
BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
2018 American Transplant Congress
Identification of Exosomal Proteins from Human Lung Transplant Recipients
S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; ²Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.
Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis
J. An,¹ Y. Kim,² M. Yu,² J. Lee,¹ C. Lee,³ Y. Kim,² S. Yang.⁴
¹Internal Medicine, Boramae Medical Center, Seoul, Korea; ²Internal Medicine, Seoul National University Hospital, Seoul, Korea; ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea; ⁴Internal Medicine, Seoul National University Kidney Research Institute, Seoul, Korea.
CD1d-restrictive NKT cells may modulate various chronic autoimmunity through secreting multiple cytokines, but the functional relationships between the different subpopulation still are poorly understood. The…
2018 American Transplant Congress
Eculizumab for the Treatment of Antibody Mediated Rejection in Kidney Transplant Recipients: A Single Center Experience
A. Chi, J. Phillips, D. Quan.
Pharmaceutical Services, UCSF Medical Center, San Francisco, CA.
BACKGROUND: Antibody mediated rejection (ABMR) accounts for 20-30% of acute rejection episodes and can affect long-term renal allograft survival. The complement system plays an active…
2018 American Transplant Congress
Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection
K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.
Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Ohio State University, Columbus, OH; Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Washington University, Saint Louis, MO.
Antibody mediated rejection continues to be one of the most detrimental complications of kidney transplant. Multiple therapeutic strategies focused on B cell and/or HLA antibody…
2018 American Transplant Congress
Single Center Experience in Use of Check Point Inhibitors and Outcomes in Kidney Transplant Recipients
K. Venkatachalam, R. Delos Santos, T. Alhamad.
Transplant Nephrology, Washington University, St. Louis, MO; Transplant Nephrology, Washington University, St. Louis, MO.
Organ transplant recipients who are on lifelong immunosuppressive agents are those who are at increased risk of malignancies (excess absolute risk of 719 cases per…
2018 American Transplant Congress
Elevated Levels of CD19⁺ B Cells before or after Rituximab Administration is a Risk Factor for the Early Rejection of a Living Kidney Transplant
M. Kono,¹ H. Shirakawa,² S. Wakai.¹
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Urology, Ohkubo Hospital, Tokyo, Japan.
[Introduction]Rituximab (RTX) is used for desensitization in highly sensitized patients, such as those undergoing ABO-incompatible (ABOi) kidney transplantation. Although RTX is generally effective, some patients…
2018 American Transplant Congress
Clinical Significance of BK Virus-Specific ELISPOT Assay in Kidney Transplant Recipients
J. Chang,^1,2 H. Bae,³ K. Park,³ H. Lee,³ B. Choi,^1,2 C. Park,^1,2 C. Yang,^1,2 Y. Kim,^1,2 E-.J. Oh,^1,4 B. Chung.^1,2
¹Transplant Research Center, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ³Department of Biomedical Science, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ⁴Department of Laboratory Medicine, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
This study aimed to investigate whether BK virus (BKV)-specific T-cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BKV…