ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants

    A. Haj,1 J. Karl,1 R. Wiseman,1 D. O'Connor.1,2

    1Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI; 2Wisconsin National Primate Research Center, Madison, WI.

    Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…
  • 2018 American Transplant Congress

    Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity

    C. Yang, T. Zhu.

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China.

    Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
  • 2018 American Transplant Congress

    Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

    The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…
  • 2018 American Transplant Congress

    Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection

    A. Girnita,1,2 E. Portwood,2 P. Brailey,2 M. Cuffy,1 M. Cardi,1 F. Paterno,1 T. Diwan,1 S. Shah,1 A. Govil,1 R. Alloway,1 E. Woodle.1

    1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.

    Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…
  • 2018 American Transplant Congress

    Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)

    A. Vo,1 O. Aubert,2 H. Edmund,1 A. Peng,1 R. Najjar,1 S. Supreet,1 J. Choi,1 K. Lim,1 S. Jordan.1

    1Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; 2Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France.

    Introduction: Highly-HLA sensitized patients (HS) with donor specific antibodies (DSA) at transplant are at risk for Type 1 ABMR. However, the incidence of Type 2…
  • 2018 American Transplant Congress

    Impact of Bw4 and Bw6 Epitope Mismatch on Clinical Outcomes after Renal Transplantation

    C. Liu,1 D. Brennan,2 K. Lentine,3 R. Delos Santos,1 J. Li,1 A. Malone,1 T. Alhamad.1

    1Washington University in St. Louis, St. Louis; 2Johns Hopkins University, Baltimore; 3Saint Louis University, St. Louis.

    HLA class II epitope mismatch has been shown to impact the long-term survival of kidney allografts. HLA-B alleles are traditionally grouped by the Bw4 and…
  • 2018 American Transplant Congress

    Pre-Emptive Rituximab and Intravenous Immunoglobulin (IVIg) Fail to Prevent Rejection in Kidney Transplant Recipients (KTx) with Donor Specific Antibodies (DSA)

    J. Crew, R. Vasilescu, E. Campenot, S. Mohan, S. Patel.

    Columbia University, New York, NY.

    Introduction:IVIg and Rituximab have been used successfully to improve transplantation rates in sensitized patients. DSA detected by Flow crossmatch (FXM+) or Luminex® at time of…
  • 2018 American Transplant Congress

    Standard- versus Low-Dose Valganciclovir for Cytomegalovirus Prophylaxis in Intermediate-Risk Kidney Transplant Recipients

    N. Wilson, N. Sulejmani, A. Jantz, A. Patel, B. Summers.

    Henry Ford Hospital, Detroit, MI.

    Background: Although guidelines recommend valganciclovir (VGC) 900 mg daily for cytomegalovirus (CMV) prophylaxis in solid organ transplant patients, multiple centers have reported clinical success, reduced…
  • 2018 American Transplant Congress

    Retrospective Study of Cryptococcosis in Kidney Transplant Recipients from a Single Center

    R. Wang, M. Cen, J. Lin, H. Huang, W. Peng, J. Wu.

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.

    Background: The mortality of Cryptococcosis remains unchanged among kidney transplant recipients(KTR) over the past two decades, and the prognosis of Cryptococcosis is yet unpredicted. Hence,…
  • 2018 American Transplant Congress

    Effect of Everolimus on Body Composition; 1-Year after Kidney Transplantation

    M. Yoshikawa,1 T. Ishimura,2 S. Nishi.1

    1Division of Nephrology, Kobe University Graduate School of Medicine, Kobe, Japan; 2Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

    【Background】Weight gain, and especially visceral fat gain early after kidney transplantation has a worse outcome for metabolic disorder, graft function, and cardiovascular disease. The mammalian…
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